Epigenetic control of skeletal muscle atrophy.
Histone modifications
Skeletal muscle atrophy
Ubiquitin–proteasome
epigenetic
m6A
Journal
Cellular & molecular biology letters
ISSN: 1689-1392
Titre abrégé: Cell Mol Biol Lett
Pays: England
ID NLM: 9607427
Informations de publication
Date de publication:
08 Jul 2024
08 Jul 2024
Historique:
received:
25
03
2024
accepted:
26
06
2024
medline:
9
7
2024
pubmed:
9
7
2024
entrez:
8
7
2024
Statut:
epublish
Résumé
Skeletal muscular atrophy is a complex disease involving a large number of gene expression regulatory networks and various biological processes. Despite extensive research on this topic, its underlying mechanisms remain elusive, and effective therapeutic approaches are yet to be established. Recent studies have shown that epigenetics play an important role in regulating skeletal muscle atrophy, influencing the expression of numerous genes associated with this condition through the addition or removal of certain chemical modifications at the molecular level. This review article comprehensively summarizes the different types of modifications to DNA, histones, RNA, and their known regulators. We also discuss how epigenetic modifications change during the process of skeletal muscle atrophy, the molecular mechanisms by which epigenetic regulatory proteins control skeletal muscle atrophy, and assess their translational potential. The role of epigenetics on muscle stem cells is also highlighted. In addition, we propose that alternative splicing interacts with epigenetic mechanisms to regulate skeletal muscle mass, offering a novel perspective that enhances our understanding of epigenetic inheritance's role and the regulatory network governing skeletal muscle atrophy. Collectively, advancements in the understanding of epigenetic mechanisms provide invaluable insights into the study of skeletal muscle atrophy. Moreover, this knowledge paves the way for identifying new avenues for the development of more effective therapeutic strategies and pharmaceutical interventions.
Identifiants
pubmed: 38978023
doi: 10.1186/s11658-024-00618-1
pii: 10.1186/s11658-024-00618-1
doi:
Substances chimiques
Histones
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
99Subventions
Organisme : National Natural Science Foundation of China
ID : 32200940
Organisme : Municipal Health Commission of Nantong
ID : MS2022027
Organisme : Health Commission of Qinghai Province
ID : 2023-wjzdx-105
Informations de copyright
© 2024. The Author(s).
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