Crisis in the gut: navigating gastrointestinal challenges in Gulf War Illness with bioengineering.
Bioengineering
Gastrointestinal motility
Gulf War Illness
Neuroimmune crosstalk
Journal
Military Medical Research
ISSN: 2054-9369
Titre abrégé: Mil Med Res
Pays: England
ID NLM: 101643181
Informations de publication
Date de publication:
08 Jul 2024
08 Jul 2024
Historique:
received:
21
12
2023
accepted:
26
06
2024
medline:
9
7
2024
pubmed:
9
7
2024
entrez:
8
7
2024
Statut:
epublish
Résumé
Gulf War Illness (GWI) is characterized by a wide range of symptoms that manifests largely as gastrointestinal symptoms. Among these gastrointestinal symptoms, motility disorders are highly prevalent, presenting as chronic constipation, stomach pain, indigestion, diarrhea, and other conditions that severely impact the quality of life of GWI veterans. However, despite a high prevalence of gastrointestinal impairments among these veterans, most research attention has focused on neurological disturbances. This perspective provides a comprehensive overview of current in vivo research advancements elucidating the underlying mechanisms contributing to gastrointestinal disorders in GWI. Generally, these in vivo and in vitro models propose that neuroinflammation alters gut motility and drives the gastrointestinal symptoms reported in GWI. Additionally, this perspective highlights the potential and challenges of in vitro bioengineering models, which could be a crucial contributor to understanding and treating the pathology of gastrointestinal related-GWI.
Identifiants
pubmed: 38978144
doi: 10.1186/s40779-024-00547-2
pii: 10.1186/s40779-024-00547-2
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
45Subventions
Organisme : Congressionally Directed Medical Research Programs
ID : W81XWH-21-1-0477
Informations de copyright
© 2024. The Author(s).
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