Intermittent Fasting Targets Osteocyte Neuropeptide Y to Relieve Osteoarthritis.
fasting
neuropeptide Y
osteoarthritis
therapeutics
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
08 Jul 2024
08 Jul 2024
Historique:
revised:
20
04
2024
received:
06
01
2024
medline:
9
7
2024
pubmed:
9
7
2024
entrez:
9
7
2024
Statut:
aheadofprint
Résumé
Osteoarthritis is a highly prevalent progressive joint disease that still requires an optimal therapeutic approach. Intermittent fasting is an attractive dieting strategy for improving health. Here this study shows that intermittent fasting potently relieves medial meniscus (DMM)- or natural aging-induced osteoarthritic phenotypes. Osteocytes, the most abundant bone cells, secrete excess neuropeptide Y (NPY) during osteoarthritis, and this alteration can be altered by intermittent fasting. Both NPY and the NPY-abundant culture medium of osteocytes (OCY-CM) from osteoarthritic mice possess pro-inflammatory, pro-osteoclastic, and pro-neurite outgrowth effects, while OCY-CM from the intermittent fasting-treated osteoarthritic mice fails to induce significant stimulatory effects on inflammation, osteoclast formation, and neurite outgrowth. Depletion of osteocyte NPY significantly attenuates DMM-induced osteoarthritis and abolishes the benefits of intermittent fasting on osteoarthritis. This study suggests that osteocyte NPY is a key contributing factor in the pathogenesis of osteoarthritis and intermittent fasting represents a promising nonpharmacological antiosteoarthritis method by targeting osteocyte NPY.
Identifiants
pubmed: 38978353
doi: 10.1002/advs.202400196
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2400196Subventions
Organisme : National Natural Science Foundation of China
ID : 82125023
Organisme : National Natural Science Foundation of China
ID : 82172501
Organisme : National Natural Science Foundation of China
ID : 82372479
Organisme : National Natural Science Foundation of China
ID : 82072504
Organisme : National Natural Science Foundation of China
ID : 82200039
Organisme : Science and Technology Innovation Program of Hunan Province
ID : 2022RC1211
Organisme : China National Postdoctoral Program for Innovative Talents
ID : BX2021383
Organisme : Hunan Province Natural Science Foundation of China
ID : 2023JJ10094
Organisme : Central South University Innovation-Driven Research Programme
ID : 2023CXQD001
Organisme : Youth Science Foundation of Xiangya Hospital
ID : 2022Q07
Organisme : Hunan Provincial Innovation Foundation for Postgraduate
ID : 2022ZZTS0239
Informations de copyright
© 2024 The Authors. Advanced Science published by Wiley‐VCH GmbH.
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