Tetrodotoxin-resistant mechanosensitivity and L-type calcium channel-mediated spontaneous calcium activity in enteric neurons.
2‐APB
CaV1.2
GCamp
L‐type calcium channel
adult gut
calcium imaging
embryonic gut
enteric nervous system
fetal gut
mechanosensation
mouse
tetrodotoxin
Journal
Experimental physiology
ISSN: 1469-445X
Titre abrégé: Exp Physiol
Pays: England
ID NLM: 9002940
Informations de publication
Date de publication:
09 Jul 2024
09 Jul 2024
Historique:
received:
13
05
2024
accepted:
20
06
2024
medline:
9
7
2024
pubmed:
9
7
2024
entrez:
9
7
2024
Statut:
aheadofprint
Résumé
Gut motility undergoes a switch from myogenic to neurogenic control in late embryonic development. Here, we report on the electrical events that underlie this transition in the enteric nervous system, using the GCaMP6f reporter in neural crest cell derivatives. We found that spontaneous calcium activity is tetrodotoxin (TTX) resistant at stage E11.5, but not at E18.5. Motility at E18.5 was characterized by periodic, alternating high- and low-frequency contractions of the circular smooth muscle; this frequency modulation was inhibited by TTX. Calcium imaging at the neurogenic-motility stages E18.5-P3 showed that Ca
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Agence Nationale de la Recherche
ID : GASTROMOVE-ANR-19-CE30-0016-01
Organisme : Agence Nationale de la Recherche
ID : ANR-18-IDEX-0001
Organisme : Agence Nationale de la Recherche
ID : ANR-11-LABX-0071
Organisme : Agence Nationale de la Recherche
ID : ANR-10-INBS-04
Organisme : Agence Nationale de la Recherche
ID : ANR-11-EQPX-0029
Organisme : DHAC | National Health and Medical Research Council (NHMRC)
ID : 1156416
Organisme : IDEX Université de Paris
Organisme : Imaging platform Bioemergences-IBiSA and Imagoseine
Informations de copyright
© 2024 The Author(s). Experimental Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.
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