Internal Mammary Lymphadenopathy Does Not Impact Oncologic Outcomes in Patients Treated with Neoadjuvant Chemotherapy: Results from the I-SPY2 Clinical Trial.


Journal

Annals of surgical oncology
ISSN: 1534-4681
Titre abrégé: Ann Surg Oncol
Pays: United States
ID NLM: 9420840

Informations de publication

Date de publication:
09 Jul 2024
Historique:
received: 11 04 2024
accepted: 16 06 2024
medline: 9 7 2024
pubmed: 9 7 2024
entrez: 9 7 2024
Statut: aheadofprint

Résumé

Internal mammary lymphadenopathy (IML) plays a role in breast cancer stage and prognosis. We aimed to evaluate method of IML detection, how IML impacts response to neoadjuvant chemotherapy (NAC), and oncologic outcomes. We evaluated patients enrolled in the I-SPY-2 clinical trial from 2010 to 2022. We captured the radiographic method of IML detection (magnetic resonance imaging [MRI], positron emission tomography/computed tomography [PET/CT], or both) and compared patients with IML with those without. Rates of locoregional recurrence (LRR), distant recurrence (DR) and event-free survival (EFS) were compared by bivariate analysis. Of 2095 patients, 198 (9.5%) had IML reported on pretreatment imaging. The method of IML detection was 154 (77.8%) MRI only, 11 (5.6%) PET/CT only, and 33 (16.7%) both. Factors associated with IML were younger age (p = 0.001), larger tumors (p < 0.001), and higher tumor grade (p = 0.027). Pathologic complete response (pCR) was slightly higher in the IML group (41.4% vs. 34.0%; p = 0.03). There was no difference in breast or axillary surgery (p = 0.41 and p = 0.16), however IML patients were more likely to undergo radiation (68.2% vs. 54.1%; p < 0.001). With a median follow up of 3.72 years (range 0.4-10.2), there was no difference between IM+ versus IM- in LRR (5.6% vs. 3.8%; p = 0.25), DR (9.1% vs. 7.9%; p = 0.58), or EFS (61.6% vs. 57.2%; p = 0.48). This was true for patients with and without pCR. In this large cohort of patients treated with NAC, outcomes were not negatively impacted by IML. We demonstrated that IML influences treatment selection but is not a poor prognostic indicator when treated with modern NAC and multidisciplinary disease management.

Sections du résumé

BACKGROUND BACKGROUND
Internal mammary lymphadenopathy (IML) plays a role in breast cancer stage and prognosis. We aimed to evaluate method of IML detection, how IML impacts response to neoadjuvant chemotherapy (NAC), and oncologic outcomes.
METHODS METHODS
We evaluated patients enrolled in the I-SPY-2 clinical trial from 2010 to 2022. We captured the radiographic method of IML detection (magnetic resonance imaging [MRI], positron emission tomography/computed tomography [PET/CT], or both) and compared patients with IML with those without. Rates of locoregional recurrence (LRR), distant recurrence (DR) and event-free survival (EFS) were compared by bivariate analysis.
RESULTS RESULTS
Of 2095 patients, 198 (9.5%) had IML reported on pretreatment imaging. The method of IML detection was 154 (77.8%) MRI only, 11 (5.6%) PET/CT only, and 33 (16.7%) both. Factors associated with IML were younger age (p = 0.001), larger tumors (p < 0.001), and higher tumor grade (p = 0.027). Pathologic complete response (pCR) was slightly higher in the IML group (41.4% vs. 34.0%; p = 0.03). There was no difference in breast or axillary surgery (p = 0.41 and p = 0.16), however IML patients were more likely to undergo radiation (68.2% vs. 54.1%; p < 0.001). With a median follow up of 3.72 years (range 0.4-10.2), there was no difference between IM+ versus IM- in LRR (5.6% vs. 3.8%; p = 0.25), DR (9.1% vs. 7.9%; p = 0.58), or EFS (61.6% vs. 57.2%; p = 0.48). This was true for patients with and without pCR.
CONCLUSIONS CONCLUSIONS
In this large cohort of patients treated with NAC, outcomes were not negatively impacted by IML. We demonstrated that IML influences treatment selection but is not a poor prognostic indicator when treated with modern NAC and multidisciplinary disease management.

Identifiants

pubmed: 38980586
doi: 10.1245/s10434-024-15708-9
pii: 10.1245/s10434-024-15708-9
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. Society of Surgical Oncology.

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Auteurs

Mara A Piltin (MA)

Division of Breast and Melanoma Surgical Oncology, Department of Surgery, Mayo Clinic, Rochester, MN, USA. Piltin.mara@mayo.edu.

Peter Norwood (P)

Quantum Leap Healthcare Collaborative, San Francisco, CA, USA.

Velle Ladores (V)

Quantum Leap Healthcare Collaborative, San Francisco, CA, USA.

Rita A Mukhtar (RA)

Division of Surgical Oncology, Department of Surgery, University of California San Francisco, San Francisco, CA, USA.

Candice A Sauder (CA)

Department of Surgery, UC Davis Comprehensive Cancer Center, Sacramento, CA, USA.

Mehra Golshan (M)

Department of Surgery, Yale Medicine, New Haven, CT, USA.

Julia Tchou (J)

Division of Breast Surgery, Penn Medicine at University of Pennsylvania, Philadelphia, PA, USA.

Roshni Rao (R)

Division of Breast Surgery, Columbia University Medical Center, New York, NY, USA.

Marie Catherine Lee (MC)

Moffitt Cancer Center Comprehensive Breast Program, Tampa, FL, USA.

Jennifer Son (J)

Breast Surgical Oncology, MedStar Georgetown University Hospital, Washington, DC, USA.

Chantal Reyna (C)

Division of Surgical Oncology, Department of Surgery, Loyola University Medical Center, Mayowood, IL, USA.

Kelly Hewitt (K)

Division of Surgical Oncology and Endocrine Surgery, Vanderbilt University Medical Center, Nashvilee, TN, USA.

Henry Kuerer (H)

Department of Breast Surgical Oncology, MD Anderson Cancer Center, Houston, TX, USA.

Gretchen Ahrendt (G)

Breast Surgical Oncology, UC Health, Highlands Ranch, CO, USA.

Ian Greenwalt (I)

Breast Surgical Oncology, MedStar Georgetown University Hospital, Washington, DC, USA.

Jennifer Tseng (J)

Department of Surgery, City of Hope Orange County, Irvine, CA, USA.

Lauren Postlewait (L)

Division of Surgical Oncology, Department of Surgery, Emory University, Atlanta, GA, USA.

Marissa Howard-McNatt (M)

Department of Surgical Oncology, Wake Forest, Winston-Salem, NC, USA.

Nora Jaskowiak (N)

Department of Surgery, University of Chicago, Chicago, IL, USA.

Laura J Esserman (LJ)

Division of Surgical Oncology, Department of Surgery, University of California San Francisco, San Francisco, CA, USA.

Judy C Boughey (JC)

Division of Breast and Melanoma Surgical Oncology, Department of Surgery, Mayo Clinic, Rochester, MN, USA.

Classifications MeSH