Brain Networks, Neurotransmitters and Psychedelics: Towards a Neurochemistry of Self-Awareness.

Interoception LSD agency emotional regulation metacognition psilocybin

Journal

Current neurology and neuroscience reports
ISSN: 1534-6293
Titre abrégé: Curr Neurol Neurosci Rep
Pays: United States
ID NLM: 100931790

Informations de publication

Date de publication:
09 Jul 2024
Historique:
accepted: 17 06 2024
medline: 9 7 2024
pubmed: 9 7 2024
entrez: 9 7 2024
Statut: aheadofprint

Résumé

Self-awareness can be defined as the capacity of becoming the object of one's own awareness and, increasingly, it has been the target of scientific inquiry. Self-awareness has important clinical implications, and a better understanding of the neurochemical basis of self-awareness may help clarifying causes and developing interventions for different psychopathological conditions. The current article explores the relationship between neurochemistry and self-awareness, with special attention to the effects of psychedelics. The functioning of self-related networks, such as the default-mode network and the salience network, and how these are influenced by different neurotransmitters is discussed. The impact of psychedelics on self-awareness is reviewed in relation to specific processes, such as interoception, body ownership, agency, metacognition, emotional regulation and autobiographical memory, within a framework based on predictive coding. Improved outcomes in emotional regulation and autobiographical memory have been observed in association with the use of psychedelics, suggesting higher-order self-awareness changes, which can be modulated by relaxation of priors and improved coping mechanisms linked to cognitive flexibility. Alterations in bodily self-awareness are less consistent, being potentially impacted by doses employed, differences in acute/long-term effects and the presence of clinical conditions. Future studies investigating the effects of different molecules in rebalancing connectivity between resting-state networks may lead to novel therapeutic approaches and the refinement of existing treatments.

Identifiants

pubmed: 38980658
doi: 10.1007/s11910-024-01353-y
pii: 10.1007/s11910-024-01353-y
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

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Auteurs

Daniel C Mograbi (DC)

Department of Psychology, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro, Brazil. daniel.mograbi@kcl.ac.uk.
Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. daniel.mograbi@kcl.ac.uk.

Rafael Rodrigues (R)

Department of Psychology, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro, Brazil.

Bheatrix Bienemann (B)

Department of Psychology, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro, Brazil.

Jonathan Huntley (J)

Division of Psychiatry, University College London, London, UK.
Wellcome Centre for Human Neuroimaging, University College London, London, UK.

Classifications MeSH