Improved Detection of Drug-Induced Liver Injury by Integrating Predicted

Journal

Chemical research in toxicology
ISSN: 1520-5010
Titre abrégé: Chem Res Toxicol
Pays: United States
ID NLM: 8807448

Informations de publication

Date de publication:
09 Jul 2024
Historique:
medline: 9 7 2024
pubmed: 9 7 2024
entrez: 9 7 2024
Statut: aheadofprint

Résumé

Drug-induced liver injury (DILI) has been a significant challenge in drug discovery, often leading to clinical trial failures and necessitating drug withdrawals. Over the last decade, the existing suite of

Identifiants

DOI: 10.1021/acs.chemrestox.4c00015 PMID: 38981058
pubmed: 38981058
doi: 10.1021/acs.chemrestox.4c00015
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Srijit Seal (S)

Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Rd, Cambridge CB2 1EW, United Kingdom.
Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, United States.
ORCID: 0000-0003-2790-8679

Dominic Williams (D)

Safety Innovation, Clinical Pharmacology and Safety Sciences, AstraZeneca, Cambridge CB4 0FZ, United Kingdom.
Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0FZ, United Kingdom.

Layla Hosseini-Gerami (L)

Ignota Laboratories, County Hall, Westminster Bridge Rd, London SE1 7PB, United Kingdom.

Manas Mahale (M)

Bombay College of Pharmacy Kalina Santacruz (E), Mumbai 400 098, India.
ORCID: 0009-0007-3867-996X

Anne E Carpenter (AE)

Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, United States.
ORCID: 0000-0003-1555-8261

Ola Spjuth (O)

Department of Pharmaceutical Biosciences and Science for Life Laboratory, Uppsala University, Box 591, Uppsala SE-75124, Sweden.

Andreas Bender (A)

Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Rd, Cambridge CB2 1EW, United Kingdom.
ORCID: 0000-0002-6683-7546

Classifications MeSH