A complete chromosome substitution mapping panel reveals genome-wide epistasis in Arabidopsis.
Journal
Heredity
ISSN: 1365-2540
Titre abrégé: Heredity (Edinb)
Pays: England
ID NLM: 0373007
Informations de publication
Date de publication:
09 Jul 2024
09 Jul 2024
Historique:
received:
07
02
2024
accepted:
03
07
2024
revised:
02
07
2024
medline:
10
7
2024
pubmed:
10
7
2024
entrez:
9
7
2024
Statut:
aheadofprint
Résumé
Chromosome substitution lines (CSLs) are tentatively supreme resources to investigate non-allelic genetic interactions. However, the difficulty of generating such lines in most species largely yielded imperfect CSL panels, prohibiting a systematic dissection of epistasis. Here, we present the development and use of a unique and complete panel of CSLs in Arabidopsis thaliana, allowing the full factorial analysis of epistatic interactions. A first comparison of reciprocal single chromosome substitutions revealed a dependency of QTL detection on different genetic backgrounds. The subsequent analysis of the complete panel of CSLs enabled the mapping of the genetic interactors and identified multiple two- and three-way interactions for different traits. Some of the detected epistatic effects were as large as any observed main effect, illustrating the impact of epistasis on quantitative trait variation. We, therefore, have demonstrated the high power of detection and mapping of genome-wide epistasis, confirming the assumed supremacy of comprehensive CSL sets.
Identifiants
pubmed: 38982296
doi: 10.1038/s41437-024-00705-1
pii: 10.1038/s41437-024-00705-1
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Netherlands Organisation for Scientific Research | Stichting voor de Technische Wetenschappen (Technology Foundation STW)
ID : STW-12425
Organisme : Netherlands Organisation for Scientific Research | Stichting voor de Technische Wetenschappen (Technology Foundation STW)
ID : STW-14389
Organisme : Netherlands Organisation for Scientific Research | Stichting voor de Technische Wetenschappen (Technology Foundation STW)
ID : STW-12425
Organisme : Netherlands Organisation for Scientific Research | Stichting voor de Technische Wetenschappen (Technology Foundation STW)
ID : STW-12425
Organisme : Netherlands Organisation for Scientific Research | Stichting voor de Technische Wetenschappen (Technology Foundation STW)
ID : STW-14389
Informations de copyright
© 2024. The Author(s).
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