Role of integrins in the development of fibrosis in the trabecular meshwork.
TGFβ2
extracellular matrix
fibronectin
fibrosis
integrins
myofibroblast
trabecular meshwork
Journal
Frontiers in ophthalmology
ISSN: 2674-0826
Titre abrégé: Front Ophthalmol (Lausanne)
Pays: Switzerland
ID NLM: 9918419176106676
Informations de publication
Date de publication:
2023
2023
Historique:
received:
08
08
2023
accepted:
09
10
2023
medline:
10
7
2024
pubmed:
10
7
2024
entrez:
10
7
2024
Statut:
epublish
Résumé
Primary open angle glaucoma (POAG) is a progressive and chronic disease exhibiting many of the features of fibrosis. The extracellular matrix (ECM) in the trabecular meshwork (TM) undergoes extensive remodeling and enhanced rigidity, resembling fibrotic changes. In addition, there are changes associated with myofibroblast activation and cell contractility that further drives tissue fibrosis and stiffening. This review discusses what is known about the integrins in the TM and their involvement in fibrotic processes.
Identifiants
pubmed: 38983065
doi: 10.3389/fopht.2023.1274797
pmc: PMC11182094
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1274797Informations de copyright
Copyright © 2023 Faralli, Filla and Peters.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.