Effects of acetazolamide on linear growth in children with pseudotumor cerebri syndrome.
acetazolamide
growth
idiopathic intracranial hypertension (IIH)
pseudotumor cerebri (PTC)
weight
Journal
Frontiers in ophthalmology
ISSN: 2674-0826
Titre abrégé: Front Ophthalmol (Lausanne)
Pays: Switzerland
ID NLM: 9918419176106676
Informations de publication
Date de publication:
2022
2022
Historique:
received:
12
09
2022
accepted:
28
12
2022
medline:
6
2
2023
pubmed:
6
2
2023
entrez:
10
7
2024
Statut:
epublish
Résumé
While oral acetazolamide is a cornerstone of management of adult and pediatric PTCS, previous studies have suggested that acetazolamide used in children with other conditions may influence growth. Retrospective chart review involving a single tertiary medical center. Thirty-four children with definite or probable PTCS were identified. Analysis was restricted to individuals from whom anthropometric data were available Half of individuals (n=11/22) showed a decline in BMI Z-scores. Sixty-three percent (n=14/22) showed a decrease in height Z-scores during treatment with acetazolamide; in 6 of these 14 children who had complete data, 3 showed at least a partial recovery of height Z-scores after discontinuation of acetazolamide. Acetazolamide may be associated with growth suppression in some children treated for pediatric PTCS. In some cases, the growth suppression appears to reverse once the acetazolamide is stopped.
Sections du résumé
Background/introduction
UNASSIGNED
While oral acetazolamide is a cornerstone of management of adult and pediatric PTCS, previous studies have suggested that acetazolamide used in children with other conditions may influence growth.
Aims and methods
UNASSIGNED
Retrospective chart review involving a single tertiary medical center. Thirty-four children with definite or probable PTCS were identified. Analysis was restricted to individuals from whom anthropometric data were available
Results
UNASSIGNED
Half of individuals (n=11/22) showed a decline in BMI Z-scores. Sixty-three percent (n=14/22) showed a decrease in height Z-scores during treatment with acetazolamide; in 6 of these 14 children who had complete data, 3 showed at least a partial recovery of height Z-scores after discontinuation of acetazolamide.
Conclusion
UNASSIGNED
Acetazolamide may be associated with growth suppression in some children treated for pediatric PTCS. In some cases, the growth suppression appears to reverse once the acetazolamide is stopped.
Identifiants
pubmed: 38983548
doi: 10.3389/fopht.2022.1042529
pmc: PMC11182249
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1042529Informations de copyright
Copyright © 2023 Sheldon, Reggie, Paley, McCormack and Liu.
Déclaration de conflit d'intérêts
SR was employed by the company Ophthalmic Plastic & Cosmetic Surgery. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.