Hemodynamics regulate spatiotemporal artery muscularization in the developing circle of Willis.
artery muscularization
brain artery development
circle of Willis
developmental biology
flow hemodynamics
vascular smooth muscle cell differentiation
zebrafish
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
10 Jul 2024
10 Jul 2024
Historique:
medline:
10
7
2024
pubmed:
10
7
2024
entrez:
10
7
2024
Statut:
epublish
Résumé
Vascular smooth muscle cells (VSMCs) envelop vertebrate brain arteries and play a crucial role in regulating cerebral blood flow and neurovascular coupling. The dedifferentiation of VSMCs is implicated in cerebrovascular disease and neurodegeneration. Despite its importance, the process of VSMC differentiation on brain arteries during development remains inadequately characterized. Understanding this process could aid in reprogramming and regenerating dedifferentiated VSMCs in cerebrovascular diseases. In this study, we investigated VSMC differentiation on zebrafish circle of Willis (CoW), comprising major arteries that supply blood to the vertebrate brain. We observed that arterial specification of CoW endothelial cells (ECs) occurs after their migration from cranial venous plexus to form CoW arteries. Subsequently,
Identifiants
pubmed: 38985140
doi: 10.7554/eLife.94094
pii: 94094
doi:
pii:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : R01NS109160
Pays : United States
Organisme : NIH HHS
ID : R01DK118728
Pays : United States
Organisme : American Heart Association
ID : AHA23POST1025829
Informations de copyright
© 2024, Cheng, Xia et al.
Déclaration de conflit d'intérêts
SC, IX, RW, JA, AS, SN No competing interests declared