Association between dietary (poly)phenol intake and the ATHLOS Healthy Ageing Scale in the Polish arm of the HAPIEE study.
(Poly)phenols
Central and Eastern Europe
Healthy aging
Scale
Journal
GeroScience
ISSN: 2509-2723
Titre abrégé: Geroscience
Pays: Switzerland
ID NLM: 101686284
Informations de publication
Date de publication:
10 Jul 2024
10 Jul 2024
Historique:
received:
02
04
2024
accepted:
28
06
2024
medline:
10
7
2024
pubmed:
10
7
2024
entrez:
10
7
2024
Statut:
aheadofprint
Résumé
Inverse association between (poly)phenol intake and age-related disorders has been demonstrated; however, little is known whether they affect comprehensively assessed healthy aging. The aim of this study was to evaluate the associations between the intake of (poly)phenol (including selected classes and subclasses) and healthy aging scores related to biopsychosocial aspects of health and functioning. A cross-sectional study was performed using data on 9774 randomly selected citizens of Krakow (Poland) who were 45-69 years of age. Dietary (poly)phenol intake was evaluated using a food frequency questionnaire and matching food consumption data with the Phenol-Explorer database. The healthy aging scores were estimated from the ATHLOS Healthy Ageing Scale (HAS) developed by the Ageing Trajectories of Health-Longitudinal Opportunities and Synergies (ATHLOS) consortium. Beta coefficients were calculated using multivariable linear regression models. In multivariable adjusted models, there were significant positive associations between the ATHLOS HAS score and intake of total (poly)phenols (b per increase of 100 mg/day = 0.081; 95% CI, 0.050; 0.112) and among main classes of (poly)phenols with phenolic acids (b = 0.139; 95% CI, 0.098; 0.180). Intake of remaining classes of (poly)phenols (flavonoids, lignans, stilbenes, and others) was not related to the ATHLOS HAS score. Among individual classes studied, hydroxycinnamic acids, flavonols, flavones, and dihydrochalcones were associated with better healthy aging. The findings suggest the beneficial effect of total dietary (poly)phenol and some classes and subclasses of (poly)phenol intake in terms of healthy aging in Poland. These findings should be confirmed in other settings and with prospective data.
Identifiants
pubmed: 38985401
doi: 10.1007/s11357-024-01275-0
pii: 10.1007/s11357-024-01275-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Narodowe Centrum Nauki
ID : 2018/29/B/NZ7/02118
Organisme : Horizon 2020
ID : 635316
Organisme : Wellcome Trust
ID : 064947
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 081081
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R01 AG23522-01
Pays : United States
Organisme : John D. and Catherine T. MacArthur Foundation
ID : 712058
Informations de copyright
© 2024. The Author(s).
Références
Eurostat. Ageing Europe. Looking at the lives of older people in the EU. 2020. https://ec.europa.eu/eurostat/web/products-statistical-books/-/ks-02-20-655 . https://doi.org/10.2785/628105 . Accessed 29 Oct 2023.
Rudnicka E, Napierała P, Podfigurna A, Męczekalski B, Smolarczyk R, Grymowicz M. The World Health Organization (WHO) approach to healthy ageing. Maturitas. 2020;139:6–11. https://doi.org/10.1016/j.maturitas.2020.05.018 .
doi: 10.1016/j.maturitas.2020.05.018
pubmed: 32747042
pmcid: 7250103
GBD 2019 Diseases and Injuries Collaborators. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet.2020; 396:1204–1222. https://doi.org/10.1016/S0140-6736(20)30925-9
Rapp T, Ronchetti J, Sicsic J. Where are populations aging better? A global comparison of healthy aging across organization for economic cooperation and development countries. Value Health. 2022;25:1520–7. https://doi.org/10.1016/j.jval.2022.05.007 .
doi: 10.1016/j.jval.2022.05.007
pubmed: 35710893
Critselis E, Panaretos D, Sánchez-Niubò A, Giné-Vázquez I, Ayuso-Mateos JL, Caballero FF, de la Fuente J, Haro JM, Panagiotakos D. Ageing trajectories of health-longitudinal opportunities and synergies (ATHLOS) Healthy Ageing Scale in adults from 16 international cohorts representing 38 countries worldwide. J Epidemiol Community Health. 2020;74:1043–9. https://doi.org/10.1136/jech-2020-214496 .
doi: 10.1136/jech-2020-214496
pubmed: 32801117
Wang Y, Dong C, Han Y, Gu Z, Sun C. Immunosenescence, aging and successful aging. Front Immunol. 2022;13:942796. https://doi.org/10.3389/fimmu.2022.942796 .
doi: 10.3389/fimmu.2022.942796
pubmed: 35983061
pmcid: 9379926
Grosso G, Laudisio D, Frias-Toral E, Barrea L, Muscogiuri G, Savastano S, Colao A. Anti-inflammatory nutrients and obesity-associated metabolic-inflammation: state of the art and future direction. Nutrients. 2022;14:1137. https://doi.org/10.3390/nu14061137 .
doi: 10.3390/nu14061137
pubmed: 35334794
pmcid: 8954840
Khemka S, Reddy A, Garcia RI, Jacobs M, Reddy RP, Roghani AK, Pattoor V, Basu T, Sehar U, Reddy PH. Role of diet and exercise in aging, Alzheimer’s disease, and other chronic diseases. Ageing Res Rev. 2023;91:102091. https://doi.org/10.1016/j.arr.2023.102091 .
doi: 10.1016/j.arr.2023.102091
pubmed: 37832608
Abud T, Kounidas G, Martin KR, Werth M, Cooper K, Myint PK. Determinants of healthy ageing: a systematic review of contemporary literature. Aging Clin Exp Res. 2022;34:1215–23. https://doi.org/10.1007/s40520-021-02049-w .
doi: 10.1007/s40520-021-02049-w
pubmed: 35132578
pmcid: 8821855
Stepaniak U, Polak M, Stefler D, Kozela M, Bobak M, Sanchez-Niubo A, Ayuso-Mateos JL, Haro JM, Pająk A. Relationship between dietary macronutrients intake and the ATHLOS Healthy Ageing Scale: results from the Polish arm of the HAPIEE Study. Nutrients. 2022;14:2454. https://doi.org/10.3390/nu14122454 .
doi: 10.3390/nu14122454
pubmed: 35745184
pmcid: 9229969
Del Rio D, Rodriguez-Mateos A, Spencer JP, Tognolini M, Borges G, Crozier A. Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxid Redox Signal. 2013;18:1818–92. https://doi.org/10.1089/ars.2012.4581 .
doi: 10.1089/ars.2012.4581
pubmed: 22794138
pmcid: 3619154
Grosso G. Effects of polyphenol-rich foods on human health. Nutrients. 2018;10:1089. https://doi.org/10.3390/nu10081089 .
doi: 10.3390/nu10081089
pubmed: 30110959
pmcid: 6115785
Pereira QC, Dos Santos TW, Fortunato IM, Ribeiro ML. The molecular mechanism of polyphenols in the regulation of ageing hallmarks. Int J Mol Sci. 2023;24:5508. https://doi.org/10.3390/ijms24065508 .
doi: 10.3390/ijms24065508
pubmed: 36982583
pmcid: 10049696
Luo J, Si H, Jia Z, Liu D. Dietary anti-aging polyphenols and potential mechanisms. Antioxidants (Basel). 2021;10:283. https://doi.org/10.3390/antiox10020283 .
doi: 10.3390/antiox10020283
pubmed: 33668479
Caruso G, Torrisi SA, Mogavero MP, Currenti W, Castellano S, Godos J, Ferri R, Galvano F, Leggio GM, Grosso G, Caraci F. Polyphenols and neuroprotection: therapeutic implications for cognitive decline. Pharmacol Ther. 2022;232:108013. https://doi.org/10.1016/j.pharmthera.2021.108013 .
doi: 10.1016/j.pharmthera.2021.108013
pubmed: 34624428
Godos J. Do antioxidant phytochemicals play a role in neurodegenerative disorders? Case Polyphenols Nutrients. 2022;14:4826. https://doi.org/10.3390/nu1422482 .
doi: 10.3390/nu1422482
pubmed: 36432513
Esposito S, Gialluisi A, Costanzo S, Di Castelnuovo A, Ruggiero E, De Curtis A, Persichillo M, Cerletti C, Donati MB, de Gaetano G, Iacoviello L, Bonaccio M, On Behalf Of The Investigators For The Moli-Sani Study. Dietary polyphenol intake is associated with biological aging, a novel predictor of cardiovascular disease: cross-sectional findings from the Moli-Sani Study. Nutrients. 1;13:1701. https://doi.org/10.3390/nu13051701
María Mérida D, Vitelli-Storelli F, Moreno-Franco B, Rodríguez-Ayala M, López-García E, Banegas JR, Rodríguez-Artalejo F, Guallar-Castillón P. Polyphenol intake and mortality: a nationwide cohort study in the adult population of Spain. Clin Nutr. 2023;42:1076–85. https://doi.org/10.1016/j.clnu.2023.05.020 .
doi: 10.1016/j.clnu.2023.05.020
Taguchi C, Kishimoto Y, Fukushima Y, Kondo K, Yamakawa M, Wada K, Nagata C. Dietary intake of total polyphenols and the risk of all-cause and specific-cause mortality in Japanese adults: the Takayama study. Eur J Nutr. 2020;59:1263–71. https://doi.org/10.1007/s00394-019-02136-9 .
doi: 10.1007/s00394-019-02136-9
pubmed: 31732850
Tresserra-Rimbau A, Rimm EB, Medina-Remón A, Martínez-González MA, López-Sabater MC, Covas MI, Corella D, Salas-Salvadó J, Gómez-Gracia E, Lapetra J, Arós F, Fiol M, Ros E, Serra-Majem L, Pintó X, Muñoz MA, Gea A, Ruiz-Gutiérrez V, Estruch R, Lamuela-Raventós RM; PREDIMED Study Investigators. Polyphenol intake and mortality risk: a re-analysis of the PREDIMED trial. BMC Med. 2014;12:77. https://doi.org/10.1186/1741-7015-12-77
Grosso G, Micek A, Godos J, Pajak A, Sciacca S, Galvano F, Giovannucci EL. Dietary flavonoid and lignan intake and mortality in prospective cohort studies: systematic review and dose-response meta-analysis. Am J Epidemiol. 2017;185:1304–16. https://doi.org/10.1093/aje/kww207 .
doi: 10.1093/aje/kww207
pubmed: 28472215
Godos J, Micek A, Mena P, Del Rio D, Galvano F, Castellano S, Grosso G. Dietary (poly)phenols and cognitive decline: a systematic review and meta-analysis of observational studies. Mol Nutr Food Res. 2024;68:e2300472. https://doi.org/10.1002/mnfr.202300472 .
doi: 10.1002/mnfr.202300472
pubmed: 37888840
Xing W, Gao W, Zhao Z, Xu X, Bu H, Su H, Mao G, Chen J. Dietary flavonoids intake contributes to delay biological aging process: analysis from NHANES dataset. J Transl Med. 2023;21:492. https://doi.org/10.1186/s12967-023-04321-1 .
doi: 10.1186/s12967-023-04321-1
pubmed: 37480074
pmcid: 10362762
Zamora-Ros R, Rabassa M, Cherubini A, Urpí-Sardà M, Bandinelli S, Ferrucci L, Andres-Lacueva C. High concentrations of a urinary biomarker of polyphenol intake are associated with decreased mortality in older adults. J Nutr. 2013;143:1445–50. https://doi.org/10.3945/jn.113.177121 .
doi: 10.3945/jn.113.177121
pubmed: 23803472
pmcid: 3743274
Ponzo V, Goitre I, Fadda M, Gambino R, De Francesco A, Soldati L, Gentile L, Magistroni P, Cassader M, Bo S. Dietary flavonoid intake and cardiovascular risk: a population-based cohort study. J Transl Med. 2015;13:218. https://doi.org/10.1186/s12967-015-0573-2 .
doi: 10.1186/s12967-015-0573-2
pubmed: 26152229
pmcid: 4494724
Rabassa M, Cherubini A, Zamora-Ros R, Urpi-Sarda M, Bandinelli S, Ferrucci L, Andres-Lacueva C. Low levels of a urinary biomarker of dietary polyphenol are associated with substantial cognitive decline over a 3-year period in older adults: the Invecchiare in Chianti study. J Am Geriatr Soc. 2015;63:938–46. https://doi.org/10.1111/jgs.13379 .
doi: 10.1111/jgs.13379
pubmed: 25919574
pmcid: 5873306
Rabassa M, Zamora-Ros R, Andres-Lacueva C, Urpi-Sarda M, Bandinelli S, Ferrucci L, Cherubini A. Association between both total baseline urinary and dietary polyphenols and substantial physical performance decline risk in older adults: a 9-year follow-up of the InCHIANTI study. J Nutr Health Aging. 2016;20:478–85. https://doi.org/10.1007/s12603-015-0600-2 .
doi: 10.1007/s12603-015-0600-2
pubmed: 27102783
pmcid: 5155507
Peasey A, Bobak M, Malyutina KR, Pajak S, Tamosiunas A, Pikhart H, Nicholson A, Marmo M. Determinants of cardiovascular disease and other non-communicable diseases in Central and Eastern Europe: rationale and design of the HAPIEE study. BMC Public Health. 2006;6(1):255. https://doi.org/10.1186/1471-2458-6-255 .
doi: 10.1186/1471-2458-6-255
pubmed: 17049075
pmcid: 1626086
Boylan S, Welch A, Pikhart H, Malyutina S, Pajak A, Kubinova R, Bragina O, Simonova G, Stepaniak U, Gilis-Januszewska A, Milla L, Peasey A, Marmot M, Bobak M. Dietary habits in three Central and Eastern European countries: the HAPIEE study. BMC Public Health. 2009;9:439. https://doi.org/10.1186/1471-2458-9-439 .
doi: 10.1186/1471-2458-9-439
pubmed: 19951409
pmcid: 2791768
Rothwell JA, Perez-Jimenez J, Neveu V, Medina-Remón A, M’hiri N, García-Lobato P, Manach C, Knox C, Eisner R, Wishart DS, Scalbert A. Phenol-Explorer 3.0: a major update of the Phenol-Explorer database to incorporate data on the effects of food processing on polyphenol content. Database (Oxford). 2013; 2013:bat070. https://doi.org/10.1093/database/bat070 .
Grosso G, Stepaniak U, Topor-Mądry R, Szafraniec K, Pająk A. Estimated dietary intake and major food sources of polyphenols in the Polish arm of the HAPIEE study. Nutrition. 2014;30:1398–403. https://doi.org/10.1016/j.nut.2014.04.012 .
doi: 10.1016/j.nut.2014.04.012
pubmed: 25280419
pmcid: 4192147
Sanchez-Niubo A, Forero CG, Wu YT, Giné-Vázquez I, Prina M, De La Fuente J, Daskalopoulou C, Critselis E, De La Torre-Luque A, Panagiotakos D, Arndt H, Ayuso-Mateos JL, Bayes-Marin I, Bickenbach J, Bobak M, Caballero FF, Chatterji S, Egea-Cortés L, García-Esquinas E, Leonardi M, Koskinen S, Koupil I, Mellor-Marsá B, Olaya B, Pająk A, Prince M, Raggi A, Rodríguez-Artalejo F, Sanderson W, Scherbov S, Tamosiunas A, Tobias-Adamczyk B, Tyrovolas S, Haro JM; ATHLOS Consortium. Development of a common scale for measuring healthy ageing across the world: results from the ATHLOS consortium. Int J Epidemiol. 50:880–892. https://doi.org/10.1093/ije/dyaa236
Kozela M, Pająk A, Szafraniec K, Ayuso-Mateos JL, Bobak M, Lu W, Pikhart H, Polak M, Sanchez-Niubo A, Stepaniak U, Haro JM. ATHLOS Healthy Aging Scale score as the predictor of all-cause mortality in Poland and Czechia. Front Public Health. 2023;11:1114497. https://doi.org/10.3389/fpubh.2023.1114497 .
doi: 10.3389/fpubh.2023.1114497
pubmed: 37006584
pmcid: 10061126
Willett WC, Howe GR, Kushi LH. 1997 Adjustment for total energy intake in epidemiologic studies. Am J Clin Nutr. 65:1220S-1228S; discussion 1229S. https://doi.org/10.1093/ajcn/65.4.1220S
Schwingshackl L, Morze J, Hoffmann G. Mediterranean diet and health status: active ingredients and pharmacological mechanisms. Br J Pharmacol. 2020;177:1241–57. https://doi.org/10.1111/bph.14778 .
doi: 10.1111/bph.14778
pubmed: 31243760
Guo X-F, Ruan Y, Li Z-H, Li D. Flavonoid subclasses and type 2 diabetes mellitus risk: a meta-analysis of prospective cohort studies. Crit Rev Food Sci Nutr. 2019;59:2850–62. https://doi.org/10.1080/10408398.2018.1476964 .
doi: 10.1080/10408398.2018.1476964
pubmed: 29768032
Xia M, Chen Y, Li W, Qian C. Lignan intake and risk of cardiovascular disease and type 2 diabetes: a meta-analysis of prospective cohort studies. Int J Food Sci Nutr. 2023;74:501–9. https://doi.org/10.1080/09637486.2023.2220985 .
doi: 10.1080/09637486.2023.2220985
pubmed: 37282605
Godos J, Vitale M, Micek A, Ray S, Martini D, Del Rio D, Riccardi G, Galvano F, Grosso G. Dietary polyphenol intake, blood pressure, and hypertension: a systematic review and meta-analysis of observational studies. Antioxidants (Basel). 2019;8:152. https://doi.org/10.3390/antiox8060152 .
doi: 10.3390/antiox8060152
pubmed: 31159186
Micek A, Godos J, Del Rio D, Galvano F, Grosso G. Dietary flavonoids and cardiovascular disease: a comprehensive dose-response meta-analysis. Mol Nutr Food Res. 2021;65:e2001019. https://doi.org/10.1002/mnfr.202001019 .
doi: 10.1002/mnfr.202001019
pubmed: 33559970
Grosso G, Godos J, Lamuela-Raventos R, Ray S, Micek A, Pajak A, Sciacca S, D’Orazio N, Del Rio D, Galvano F. A comprehensive meta-analysis on dietary flavonoid and lignan intake and cancer risk: level of evidence and limitations. Mol Nutr Food Res. 2017;61. https://doi.org/10.1002/mnfr.201600930
Grosso G, Stepaniak U, Micek A, Stefler D, Bobak M, Pająk A. Dietary polyphenols are inversely associated with metabolic syndrome in Polish adults of the HAPIEE study. Eur J Nutr. 2017;56:1409–20. https://doi.org/10.1007/s00394-016-1187-z .
doi: 10.1007/s00394-016-1187-z
pubmed: 26913852
Grosso G, Stepaniak U, Micek A, Kozela M, Stefler D, Bobak M, Pajak A. Dietary polyphenol intake and risk of type 2 diabetes in the Polish arm of the Health, Alcohol and Psychosocial factors in Eastern Europe (HAPIEE) study. Br J Nutr. 2017;118:60–8. https://doi.org/10.1017/S0007114517001805 .
doi: 10.1017/S0007114517001805
pubmed: 28799519
pmcid: 5565930
Grosso G, Stepaniak U, Micek A, Kozela M, Stefler D, Bobak M, Pajak A. Dietary polyphenol intake and risk of hypertension in the Polish arm of the HAPIEE study. Eur J Nutr. 2018;57:1535–44. https://doi.org/10.1007/s00394-017-1438-7 .
doi: 10.1007/s00394-017-1438-7
pubmed: 28474120
Urpi-Sarda M, Andres-Lacueva C, Rabassa M, Ruggiero C, Zamora-Ros R, Bandinelli S, Ferrucci L, Cherubini A. The relationship between urinary total polyphenols and the frailty phenotype in a community-dwelling older population: the InCHIANTI study. J Gerontol A Biol Sci Med Sci. 2015;70:1141–7. https://doi.org/10.1093/gerona/glv026 .
doi: 10.1093/gerona/glv026
pubmed: 25838546
pmcid: 4817083
Godos J, Caraci F, Micek A, Castellano S, D’Amico E, Paladino N, Ferri R, Galvano F, Grosso G. Dietary phenolic acids and their major food sources are associated with cognitive status in older Italian adults. Antioxidants (Basel). 2021;10:700. https://doi.org/10.3390/antiox10050700 .
doi: 10.3390/antiox10050700
pubmed: 33946636
Goni L, Fernández-Matarrubia M, Romanos-Nanclares A, Razquin C, Ruiz-Canela M, Martínez-González MÁ, Toledo E. Polyphenol intake and cognitive decline in the Seguimiento Universidad de Navarra (SUN) Project. Br J Nutr. 2021;126:43–52. https://doi.org/10.1017/S000711452000392X .
doi: 10.1017/S000711452000392X
pubmed: 33028430
Kesse-Guyot E, Fezeu L, Andreeva VA, Touvier M, Scalbert A, Hercberg S, Galan P. Total and specific polyphenol intakes in midlife are associated with cognitive function measured 13 years later. J Nutr. 2012;142:76–83. https://doi.org/10.3945/jn.111.144428 .
doi: 10.3945/jn.111.144428
pubmed: 22090468
Salomone F, Ivancovsky-Wajcman D, Fliss-Isakov N, Webb M, Grosso G, Godos J, Galvano F, Shibolet O, Kariv R, Zelber-Sagi S. Higher phenolic acid intake independently associates with lower prevalence of insulin resistance and non-alcoholic fatty liver disease. JHEP Rep. 2020;2:100069. https://doi.org/10.1016/j.jhepr.2020.100069 .
doi: 10.1016/j.jhepr.2020.100069
pubmed: 32195455
pmcid: 7078532
Grosso G, Godos J, Galvano F, Giovannucci EL. Coffee, caffeine, and health outcomes: an umbrella review. Annu Rev Nutr. 2017;37:131–56. https://doi.org/10.1146/annurev-nutr-071816-064941 .
doi: 10.1146/annurev-nutr-071816-064941
pubmed: 28826374
Mazeaud S, Castellana F, Coelho-Junior HJ, Panza F, Rondanelli M, Fassio F, De Pergola G, Zupo R, Sardone R. Coffee drinking and adverse physical outcomes in the aging adult population: a systematic review. Metabolites. 2022;12:654. https://doi.org/10.3390/metabo12070654 .
doi: 10.3390/metabo12070654
pubmed: 35888778
pmcid: 9318773
Grosso G, Stepaniak U, Micek A, Topor-Mądry R, Pikhart H, Szafraniec K, Pająk A. Association of daily coffee and tea consumption and metabolic syndrome: results from the Polish arm of the HAPIEE study. Eur J Nutr. 2015;54:1129–37. https://doi.org/10.1007/s00394-014-0789-6 .
doi: 10.1007/s00394-014-0789-6
pubmed: 25367317
Grosso G, Stepaniak U, Micek A, Stefler D, Bobak M, Pajak A. Coffee consumption and mortality in three Eastern European countries: results from the HAPIEE (Health, Alcohol and Psychosocial factors In Eastern Europe) study. Public Health Nutr. 2017;20:82–91. https://doi.org/10.1017/S1368980016001749 .
doi: 10.1017/S1368980016001749
pubmed: 27411779
Zamora-Ros R, Jiménez C, Cleries R, Agudo A, Sánchez MJ, Sánchez-Cantalejo E, Molina-Montes E, Navarro C, Chirlaque MD, María Huerta J, Amiano P, Redondo ML, Barricarte A, González CA. Dietary flavonoid and lignan intake and mortality in a Spanish cohort. Epidemiology. 2013;24:726–33. https://doi.org/10.1097/EDE.0b013e31829d5902 .
doi: 10.1097/EDE.0b013e31829d5902
pubmed: 23881072
Ivey KL, Hodgson JM, Croft KD, Lewis JR, Prince RL. Flavonoid intake and all-cause mortality. Am J Clin Nutr. 2015;101:1012–20. https://doi.org/10.3945/ajcn.113.073106 .
doi: 10.3945/ajcn.113.073106
pubmed: 25832340
Godos J, Caraci F, Castellano S, Currenti W, Galvano F, Ferri R, Grosso G. Association between dietary flavonoids intake and cognitive function in an Italian cohort. Biomolecules. 2020;10:1300. https://doi.org/10.3390/biom10091300 .
doi: 10.3390/biom10091300
pubmed: 32916935
pmcid: 7565262
Samieri C, Sun Q, Townsend MK, Rimm EB, Grodstein F. Dietary flavonoid intake at midlife and healthy aging in women. Am J Clin Nutr. 2014;100:1489–97. https://doi.org/10.3945/ajcn.114.085605 .
doi: 10.3945/ajcn.114.085605
pubmed: 25411284
pmcid: 4232017
Godos J, Marventano S, Mistretta A, Galvano F, Grosso G. Dietary sources of polyphenols in the Mediterranean healthy Eating, Aging and Lifestyle (MEAL) study cohort. Int J Food Sci Nutr. 2017;68:750–6. https://doi.org/10.1080/09637486.2017.1285870 .
doi: 10.1080/09637486.2017.1285870
pubmed: 28276907
Kim K, Vance TM, Chun OK. Estimated intake and major food sources of flavonoids among US adults: changes between 1999–2002 and 2007–2010 in NHANES. Eur J Nutr. 2016;55:833–43. https://doi.org/10.1007/s00394-015-0942-x .
doi: 10.1007/s00394-015-0942-x
pubmed: 26026481
Adriouch S, Lampuré A, Nechba A, Baudry J, Assmann K, Kesse-Guyot E, Hercberg S, Scalbert A, Touvier M, Fezeu LK. Prospective association between total and specific dietary polyphenol intakes and cardiovascular disease risk in the Nutrinet-Santé French cohort. Nutrients. 2018;10:1587. https://doi.org/10.3390/nu10111587 .
doi: 10.3390/nu10111587
pubmed: 30380657
pmcid: 6266343
Hejazi J, Ghanavati M, Hejazi E, Poustchi H, Sepanlou SG, Khoshnia M, Gharavi A, Sohrabpour AA, Sotoudeh M, Dawsey SM, Boffetta P, Abnet CC, Kamangar F, Etemadi A, Pourshams A, FazeltabarMalekshah A, Brennan P, Malekzadeh R, Hekmatdoost A. Habitual dietary intake of flavonoids and all-cause and cause-specific mortality: Golestan cohort study. Nutr J. 2020;19:108. https://doi.org/10.1186/s12937-020-00627-8 .
doi: 10.1186/s12937-020-00627-8
pubmed: 32988395
pmcid: 7523365
Rejman K, Górska-Warsewicz H, Kaczorowska J, Laskowski W. Nutritional significance of fruit and fruit products in the average Polish diet. Nutrients. 2021;13:2079. https://doi.org/10.3390/nu13062079 .
doi: 10.3390/nu13062079
pubmed: 34204541
pmcid: 8235518
Fraga CG, Croft KD, Kennedy DO, Tomás-Barberán FA. The effects of polyphenols and other bioactives on human health. Food Funct. 2019;10:514–28. https://doi.org/10.1039/c8fo01997e .
doi: 10.1039/c8fo01997e
pubmed: 30746536
Yahfoufi N, Alsadi N, Jambi M, Matar C. The immunomodulatory and anti-inflammatory role of polyphenols. Nutrients. 2018;10:1618. https://doi.org/10.3390/nu10111618 .
doi: 10.3390/nu10111618
pubmed: 30400131
pmcid: 6266803
Meng T, Xiao D, Muhammed A, Deng J, Chen L, He J. Anti-inflammatory action and mechanisms of resveratrol. Molecules. 2021;26:229. https://doi.org/10.3390/molecules26010229 .
doi: 10.3390/molecules26010229
pubmed: 33466247
pmcid: 7796143
Zhang Y, Yu W, Zhang L, Wang M, Chang W. The interaction of polyphenols and the gut microbiota in neurodegenerative diseases. Nutrients. 2022;14:5373. https://doi.org/10.3390/nu14245373 .
doi: 10.3390/nu14245373
pubmed: 36558531
pmcid: 9785743
Iqbal AZ, Javaid N, Hameeda M. Synergic interactions between berry polyphenols and gut microbiota in cardiovascular diseases. Med J Nutrition Metab. 2022;15:555–73. https://doi.org/10.3233/MNM-220071 .
doi: 10.3233/MNM-220071
Sorrenti V, Ali S, Mancin L, Davinelli S, Paoli A, Scapagnini G. Cocoa polyphenols and gut microbiota interplay: bioavailability, prebiotic effect, and impact on human health. Nutrients. 2020;12:1908. https://doi.org/10.3390/nu12071908 .
doi: 10.3390/nu12071908
pubmed: 32605083
pmcid: 7400387
Jakobek L. Interactions of polyphenols with carbohydrates, lipids and proteins. Food Chem. 2015;175:556–67. https://doi.org/10.1016/j.foodchem.2014.12.013 .
doi: 10.1016/j.foodchem.2014.12.013
pubmed: 25577120
Bohn T. Dietary factors affecting polyphenol bioavailability. Nutr Rev. 2014;72:429–52. https://doi.org/10.1111/nure.12114 .
doi: 10.1111/nure.12114
pubmed: 24828476