Enhanced Procoagulant Activity of Select Hemophilia B Causing Factor IX Variants with Emicizumab.


Journal

Blood
ISSN: 1528-0020
Titre abrégé: Blood
Pays: United States
ID NLM: 7603509

Informations de publication

Date de publication:
10 Jul 2024
Historique:
accepted: 25 06 2024
received: 21 07 2023
revised: 20 06 2024
medline: 10 7 2024
pubmed: 10 7 2024
entrez: 10 7 2024
Statut: aheadofprint

Résumé

Emicizumab improves the procoagulant activity of select loss-of-function FIX variants with likely dysfunctional assembly of the intrinsic Xase complex that cause hemophilia B. FVIII-mimetics may represent an alternative non-factor therapy for select hemophilia B patients.

Identifiants

pubmed: 38985830
pii: 516932
doi: 10.1182/blood.2023021944
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024 American Society of Hematology.

Auteurs

Kyumin Lee (K)

The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States.

Julia Q Chau (JQ)

The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States.

Yani B Suber (YB)

The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States.

Anna R Sternberg (AR)

University of Pennsylvania, Philadelphia, Pennsylvania, United States.

Allyson Pishko (A)

University of Pennsylvania, Philadelphia, Pennsylvania, United States.

Lindsey A George (LA)

University of Pennyslvania School of Medicine, Philadelphia, Pennsylvania, United States.

Vijay Bhoj (V)

University of Pennsylvania, Philadelphia, Pennsylvania, United States.

Bhavya S Doshi (BS)

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States.

Benjamin J Samelson-Jones (BJ)

The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States.

Classifications MeSH