Health-related quality of life and symptoms of chronic myeloid leukemia patients after discontinuation of tyrosine kinase inhibitors: results from the EURO-SKI Trial.


Journal

Leukemia
ISSN: 1476-5551
Titre abrégé: Leukemia
Pays: England
ID NLM: 8704895

Informations de publication

Date de publication:
10 Jul 2024
Historique:
received: 23 04 2024
accepted: 03 07 2024
revised: 26 06 2024
medline: 11 7 2024
pubmed: 11 7 2024
entrez: 10 7 2024
Statut: aheadofprint

Résumé

Limited data is available on the health-related quality of life (HRQoL) and symptoms of patients with chronic myeloid leukemia (CML) who are in treatment-free remission (TFR). We herein report HRQoL results from the EURO-SKI trial. Patients who had been on tyrosine kinase inhibitors (TKIs) therapy for at least 3 years and achieved MR4 for at least 1 year were enrolled from 11 European countries, and the EORTC QLQ-C30 and the FACIT-Fatigue questionnaires were used to assess HRQoL and fatigue respectively. Patients were categorized into the following age groups: 18-39, 40-59, 60-69 and ≥70 years. Of 728 patients evaluated at baseline, 686 (94%) completed HRQoL assessments. The median age at TKI discontinuation was 60 years. Our findings indicate that HRQoL and symptom trajectories may vary depending on specific age groups, with younger patients benefiting the most. Improvements in patients aged 60 years or older were marginal across several HRQoL and symptom domains. At the time of considering TKI discontinuation, physicians could inform younger patients that they may expect valuable HRQoL benefits. Considering the marginal improvements observed in patients aged 60 years or above, it may be important to further investigate the value of TFR compared to a lowest effective dose approach in this older group of patients.

Identifiants

pubmed: 38987274
doi: 10.1038/s41375-024-02341-4
pii: 10.1038/s41375-024-02341-4
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Fabio Efficace (F)

Data Center and Health Outcomes Research Unit, Italian Group for Adult Haematologic Diseases (GIMEMA), Rome, Italy. f.efficace@gimema.it.

Francois-Xavier Mahon (FX)

Bergonié Cancer Institute, INSERM UMR1312 Inserm, University of Bordeaux, Bordeaux, France.

Johan Richter (J)

Department of Haematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden.

Alfonso Piciocchi (A)

Data Center and Health Outcomes Research Unit, Italian Group for Adult Haematologic Diseases (GIMEMA), Rome, Italy.

Marta Cipriani (M)

Data Center and Health Outcomes Research Unit, Italian Group for Adult Haematologic Diseases (GIMEMA), Rome, Italy.
Department of Statistical Sciences, Sapienza University of Rome, Rome, Italy.

Franck E Nicolini (FE)

Centre Léon Bérard, Service d'Hématologie Clinique & INSERM U1052 CRCL, Lyon, France.

Jiri Mayer (J)

Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Masaryk University, Brno, Czech Republic.

Daniela Zackova (D)

Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Masaryk University, Brno, Czech Republic.

Jeroen J W M Janssen (JJWM)

Department of Hematology, Radboud UMC, Nijmegen, The Netherlands.

Panayiotis Panayiotidis (P)

Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Hanne Vestergaard (H)

Department of Haematology, Odense University Hospital, Odense, Denmark.

Perttu Koskenvesa (P)

Hematology Research Unit Helsinki and HUS Cancer Center, Hematology Line, Helsinki, Finland.

Antonio Almeida (A)

Faculdade de Medicina, Universidade Católica Portuguesa, Lisbon, Portugal.
Hospital da Luz, Lisbon, Portugal.

Henrik Hjorth-Hansen (H)

St Olavs Hospital HF, Trondheim, Norway.

Joaquin Martinez-Lopez (J)

Hospital 12 de Octubre, CNIO, i+12, Department of Medicine Univ. Complutense, Madrid, Spain.

Ulla Olsson-Strömberg (U)

Department of Medical Sciences, Uppsala University and Hematology Section, Uppsala University Hospital, Uppsala, Sweden.

Andreas Hochhaus (A)

Klinik für Innere Medizin II, Universitätsklinikum Jena, Jena, Germany.

Marc G Berger (MG)

CHU Clermont-Ferrand, Hematology department, and EA 7453 CHELTER, University Clermont Auvergne, Clermont-Ferrand, France.

Gabriel Etienne (G)

Institut Bergonié, département d'hématologie, Bordeaux, France.
France Intergroupe de la leucémie myéloïde chronique Fi-LMC, Lyon, France.

Hana Klamova (H)

Institute of Hematology and Blood Transfusion, Prague, Czech Republic.

Edgar Faber (E)

Department of Hemato-oncology, Faculty Hospital and Faculty of Medicine and Dentistry, Palacký University, Olomouc, Olomouc, Czech Republic.

Philippe Rousselot (P)

Centre Hospitalier de Versailles, Department of Haematology, University Versailles Paris-Saclay, Le Chesnay, France.

Markus Pfirrmann (M)

Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie (IBE), Medizinische Fakultät, LMU München, München, Germany.

Susanne Saussele (S)

Medical Clinic, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Classifications MeSH