Psychological state at the time of psychiatric genetic counseling impacts patient empowerment: A pre-post analysis.

depression empowerment genetic counseling mental health psychiatric genetic counseling quantitative pre–post design

Journal

Journal of genetic counseling
ISSN: 1573-3599
Titre abrégé: J Genet Couns
Pays: United States
ID NLM: 9206865

Informations de publication

Date de publication:
10 Jul 2024
Historique:
revised: 26 06 2024
received: 23 02 2024
accepted: 28 06 2024
medline: 11 7 2024
pubmed: 11 7 2024
entrez: 10 7 2024
Statut: aheadofprint

Résumé

Psychiatric genetic counseling (GC) has been associated with patient-reported increases in empowerment (perceived control, emotional regulation, and hope). We sought to evaluate the extent to which patients' psychological state at the time of GC is related to changes in empowerment. Participants with a history of major depressive disorder and/or bipolar disorder that had been refractory to treatment underwent psychiatric GC remotely from 2022 to 2023. GC was performed by four genetic counselors and included discussion of perceived causes of illness, multifactorial inheritance, and protective factors. Empowerment, depression, and anxiety were measured immediately prior to GC via online survey by the GCOS-16, PHQ-9, and GAD-7, respectively. Empowerment was re-assessed 2 weeks later. In total, 66/161 (41.0%) invited individuals completed both the baseline and follow-up surveys. Participants completing both surveys were 54.6% female, 84.8% white, and ranged in age from 22 to 78 years (mean = 54.8 years). Overall, a significant change in mean empowerment was not observed (p = 0.38); however, there were moderating effects by baseline psychological state. A multiple linear regression model incorporating PHQ-9, GAD-7 and baseline GCOS-16 score predicted change in empowerment with a large effect (F = 5.49, R

Identifiants

pubmed: 38987885
doi: 10.1002/jgc4.1949
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Division of Intramural Research, National Institute of Allergy and Infectious Diseases
Organisme : National Institute of Mental Health Intramural Program

Informations de copyright

© 2024 The Author(s). Journal of Genetic Counseling published by Wiley Periodicals LLC on behalf of National Society of Genetic Counselors. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.

Références

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). American Psychiatric Association. https://doi.org/10.1176/appi.books.9780890425596
Andreassen, O. A., Hindley, G. F. L., Frei, O., & Smeland, O. B. (2023). New insights from the last decade of research in psychiatric genetics: Discoveries, challenges and clinical implications. World Psychiatry, 22(1), 4–24. https://doi.org/10.1002/wps.21034
Austin, J., Semaka, A., & Hadjipavlou, G. (2014). Conceptualizing genetic counseling as psychotherapy in the era of genomic medicine. Journal of Genetic Counseling, 23(6), 903–909. https://doi.org/10.1007/s10897‐014‐9728‐1
Austin, J. C. (2019). Evidence‐based genetic counseling for psychiatric disorders: A road map. Cold Spring Harbor Perspectives in Medicine, 10(6), a036608. https://doi.org/10.1101/cshperspect.a036608
Bjertnaes, O. (2012). The association between survey timing and patient‐reported experiences with hospitals: Results of a national post survey. BMC Medical Research Methodology, 12(13), 1–6. https://doi.org/10.1186/1471‐2288‐12‐13
Borle, K., Austin, J., & Barbic, S. (2023). Using Rasch measurement theory to explore the fitness for purpose of the genetic counseling outcome scale: A tale of two scales. Quality of Life Research: an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation, 32(3), 895–904. https://doi.org/10.1007/s11136‐022‐03289‐7
Borle, K., Morris, E., Inglis, A., & Austin, J. (2018). Risk communication in genetic counseling: Exploring uptake and perception of recurrence numbers, and their impact on patient outcomes. Clinical Genetics, 94(2), 239–245. https://doi.org/10.1111/cge.13379
Brown, S., Rittenbach, K., Cheung, S., McKean, G., MacMaster, F. P., & Clement, F. (2019). Current and common definitions of treatment‐resistant depression: Findings from a systematic review and qualitative interviews. Canadian Journal of Psychiatry, 64(6), 380–387. https://doi.org/10.1177/0706743719828965
Crowe, M., Manuel, J., Carlyle, D., Thwaites, B., & Lacey, C. (2023). The experience of “treatment‐resistant” depression: A qualitative meta‐synthesis. International Journal of Mental Health Nursing, 32(3), 662–672. https://doi.org/10.1111/inm.13107
Gerrard, S., Inglis, A., Morris, E., & Austin, J. (2020). Relationships between patient‐ and session‐related variables and outcomes of psychiatric genetic counseling. European Journal of Human Genetics, 28(7), 907–914. https://doi.org/10.1038/s41431‐020‐0592‐1
Grotzinger, A. D., Mallard, T. T., Akingbuwa, W. A., Ip, H. F., Adams, M. J., Lewis, C. M., McIntosh, A. M., Grove, J., Dalsgaard, S., Lesch, K. P., Strom, N., Meier, S. M., Mattheisen, M., Børglum, A. D., Mors, O., Breen, G., iPSYCH, Mattheisen, M., Mors, O., … Nivard, M. G. (2022). Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis. Nature Genetics, 54(5), 548–559. https://doi.org/10.1038/s41588‐022‐01057‐4
Hippman, C., Ringrose, A., Inglis, A., Cheek, J., Albert, A. Y. K., Remick, R., Honer, W. G., & Austin, J. C. (2016). A pilot randomized clinical trial evaluating the impact of genetic counseling for serious mental illnesses. The Journal of Clinical Psychiatry, 77(2), e190–e198. https://doi.org/10.4088/JCP.14m09710
Hirschfeld, R. M. (2002). The mood disorder questionnaire: A simple, patient‐rated screening instrument for bipolar disorder. Primary Care Companion to the Journal of Clinical Psychiatry, 4(1), 9–11. https://doi.org/10.4088/pcc.v04n0104
Hooker, G. W., Babu, D., Myers, M. F., Zierhut, H., & McAllister, M. (2017). Standards for the reporting of genetic counseling interventions in research and other studies (GCIRS): An NSGC task force report. Journal of Genetic Counseling, 26(3), 355–360. https://doi.org/10.1007/s10897‐017‐0076‐9
Inglis, A., Koehn, D., McGillivray, B., Stewart, S. E., & Austin, J. (2015). Evaluating a unique, specialist psychiatric genetic counseling clinic: Uptake and impact. Clinical Genetics, 87(3), 218–224. https://doi.org/10.1111/cge.12415
Kroenke, K., Spitzer, R. L., & Williams, J. B. (2001). The PHQ‐9: Validity of a brief depression severity measure. Journal of General Internal Medicine, 16(9), 606–613. https://doi.org/10.1046/j.1525‐1497.2001.016009606.x
McAllister, M., Wood, A. M., Dunn, G., Shiloh, S., & Todd, C. (2011). The genetic counseling outcome scale: A new patient‐reported outcome measure for clinical genetics services. Clinical Genetics, 79(5), 413–424. https://doi.org/10.1111/j.1399‐0004.2011.01636.x
Moldovan, R., Pintea, S., & Austin, J. (2017). The efficacy of genetic counseling for psychiatric disorders: A meta‐analysis. Journal of Genetic Counseling, 26(6), 1341–1347. https://doi.org/10.1007/s10897‐017‐0113‐8
Morris, E., Batallones, R., Ryan, J., Slomp, C., Carrion, P., Albert, A., & Austin, J. (2021). Psychiatric genetic counseling for serious mental illness: Impact on psychopathology and psychotropic medication adherence. Psychiatry Research, 296, 113663. https://doi.org/10.1016/j.psychres.2020.113663
Morris, E., McGrail, K., Cressman, S., Stewart, S. E., & Austin, J. (2024). Assessing the impact of psychiatric genetic counseling on psychiatric hospitalizations. Clinical Genetics, 105, 630–638. https://doi.org/10.1111/cge.14493
National Institute of Mental Health (2021). National Institute of Mental Health Strategic Plan for Research (NIH Publication No. 20‐MH‐8096). U.S. Department of Health and Human Services, National Institutes of Health. Retrieved December 13, 2021, from https://www.nimh.nih.gov/sites/default/files/documents/about/strategic‐planning‐reports/NIMH‐Strategic‐Plan‐for‐Research‐2021‐Update.pdf
Putt, S., Yanes, T., Meiser, B., Kaur, R., Fullerton, J. M., Barlow‐Stewart, K., Schofield, P. R., Toma, C., Peay, H., & Mitchell, P. B. (2020). Exploration of experiences with and understanding of polygenic risk scores for bipolar disorder. Journal of Affective Disorders, 265, 342–350. https://doi.org/10.1016/j.jad.2020.01.037
Semaka, A., & Austin, J. (2019). Patient perspectives on the process and outcomes of psychiatric genetic counseling: An “empowering encounter.”. Journal of Genetic Counseling, 28(4), 856–868. https://doi.org/10.1002/jgc4.1128
Spitzer, R. L., Kroenke, K., Williams, J. B. W., & Löwe, B. (2006). A brief measure for assessing generalized anxiety disorder: The GAD‐7. Archives of Internal Medicine, 166(10), 1092–1097. https://doi.org/10.1001/archinte.166.10.1092

Auteurs

Rachel Gore Moses (RG)

Centralized Sequencing Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Colleen Jodarski (C)

Centralized Sequencing Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Michael Setzer (M)

Centralized Sequencing Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Department of Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.

Katie L Lewis (KL)

Centralized Sequencing Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Jia Yan (J)

Centralized Sequencing Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Sophie Byers (S)

Centralized Sequencing Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Mani Yavi (M)

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.

Elizabeth D Ballard (ED)

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.

Magdalena Walkiewicz (M)

Centralized Sequencing Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Carlos A Zarate (CA)

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.

Jehannine C Austin (JC)

Departments of Psychiatry and Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.

Morgan Similuk (M)

Centralized Sequencing Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Classifications MeSH