Metabolic remodeling by RNA polymerase gene mutations is associated with reduced β-lactam susceptibility in oxacillin-susceptible MRSA.

Methicillin-Resistant Staphylococcus aureus / genetics Oxacillin / pharmacology DNA-Directed RNA Polymerases / genetics Anti-Bacterial Agents / pharmacology Microbial Sensitivity Tests beta-Lactams / pharmacology Bacterial Proteins / genetics Mutation, Missense Cell Wall / drug effects Humans Mutation Metabolomics
MRSA OS-MRSA RNA polymerases Staphylococcus aureus antimicrobial resistant beta-lactams oxacillin rpoBC

Journal

mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231

Informations de publication

Date de publication:
12 Jun 2024
Historique:
medline: 11 7 2024
pubmed: 11 7 2024
entrez: 11 7 2024
Statut: ppublish

Résumé

The emergence of oxacillin-susceptible methicillin-resistant The emergence of oxacillin-susceptible methicillin-resistant

Identifiants

DOI: 10.1128/mbio.00339-24 PMID: 38988221
pubmed: 38988221
doi: 10.1128/mbio.00339-24
doi:

Substances chimiques

Oxacillin UH95VD7V76
DNA-Directed RNA Polymerases EC 2.7.7.6
Anti-Bacterial Agents 0
beta-Lactams 0
Bacterial Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0033924

Subventions

Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 19K08960
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 22K19386
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 20F20104
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 21K19488
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : L21543
Organisme : Takeda Science Foundation (TSF)
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : JP21fk0108497
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : JP21fk0108496
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : JP21wm0325022
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : JP22ae0121045
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : JP21gm1610002
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : JP20fk0108134

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

Auteurs

Shinya Watanabe (S)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
ORCID: 0000-0003-3932-8575

Chijioke A Nsofor (CA)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Department of Biotechnology, School of Biological Sciences, Federal University of Technology Owerri Nigeria, Owerri, Nigeria.

Kanate Thitiananpakorn (K)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.

Xin-Ee Tan (X-E)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
ORCID: 0000-0001-7847-2583

Yoshifumi Aiba (Y)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.

Remi Takenouchi (R)

School of Medicine, Jichi Medical University, Tochigi, Japan.

Kotaro Kiga (K)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo, Japan.
ORCID: 0000-0002-0248-6951

Teppei Sasahara (T)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.

Kazuhiko Miyanaga (K)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.

Srivani Veeranarayanan (S)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.

Yuzuki Shimamori (Y)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.

Adeline Yeo Syin Lian (AYS)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.

Thuy Minh Nguyen (TM)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.

Huong Minh Nguyen (HM)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.

Ola Alessa (O)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.

Geoffrey Peterkins Kumwenda (GP)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.

Sarangi Jayathilake (S)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.

Jastin Edrian Cocuangco Revilleza (JEC)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.

Priyanka Baranwal (P)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.

Yutaro Nishikawa (Y)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.

Feng-Yu Li (F-Y)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.

Tomofumi Kawaguchi (T)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.

Sowmiya Sankaranarayanan (S)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.

Mahmoud Arbaah (M)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.

Yuancheng Zhang (Y)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.

Yi Liu (Y)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.

Hossain Sarah (H)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.

Junjie Li (J)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.

Takashi Sugano (T)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.

Thi My Duyen Ho (TMD)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.

Anujin Batbold (A)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.

Tergel Nayanjin (T)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.

Longzhu Cui (L)

Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Cocci à Gram positif › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Staphylococcus aureus résistant à la méticilline › Metabolic remodeling by RNA polymerase gene...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Pénicillines › Oxacilline › Metabolic remodeling by RNA polymerase gene...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › RNA nucleotidyltransferases › DNA-directed RNA polymerases › Metabolic remodeling by RNA polymerase gene...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Metabolic remodeling by RNA polymerase gene...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Metabolic remodeling by RNA polymerase gene...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Metabolic remodeling by RNA polymerase gene...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Metabolic remodeling by RNA polymerase gene...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutation faux-sens › Metabolic remodeling by RNA polymerase gene...
questionsmedicales.fr › Cellules › Structures cellulaires › Paroi cellulaire › Metabolic remodeling by RNA polymerase gene...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Metabolic remodeling by RNA polymerase gene...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Metabolic remodeling by RNA polymerase gene...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Métabolomique › Metabolic remodeling by RNA polymerase gene...