Discovery of Uncommon Tryptophan-Containing Diketopiperazines from

Journal

Journal of natural products
ISSN: 1520-6025
Titre abrégé: J Nat Prod
Pays: United States
ID NLM: 7906882

Informations de publication

Date de publication:
11 Jul 2024
Historique:
medline: 11 7 2024
pubmed: 11 7 2024
entrez: 11 7 2024
Statut: aheadofprint

Résumé

Fungal secondary metabolite (SM) biosynthetic gene clusters (BGCs) containing dimethylallyltryptophan synthases (DMATSs) produce structurally diverse prenylated indole alkaloids with wide-ranging activities that have vast potential as human therapeutics. To discover new natural products produced by DMATSs, we mined the Department of Energy Joint Genome Institute's MycoCosm database for DMATS-containing BGCs. We found a DMATS BGC in

Identifiants

DOI: 10.1021/acs.jnatprod.4c00113 PMID: 38990199
pubmed: 38990199
doi: 10.1021/acs.jnatprod.4c00113
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Cory B Jenkinson (CB)

Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045, United States.

Shu-Yi Lin (SY)

School of Pharmacy, National Defense Medical Center, Taipei, 11490, Taiwan.
Department of Pharmacology and Pharmaceutical Sciences, Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90089, United States.
ORCID: 0000-0001-7982-136X

Mary Villarreal (M)

Department of Pharmacology and Pharmaceutical Sciences, Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90089, United States.
Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.

C Elizabeth Oakley (CE)

Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045, United States.
ORCID: 0000-0001-7170-4775

David H Sherman (DH)

Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.
Departments of Medicinal Chemistry, Chemistry, Microbiology & Immunology, University of Michigan, Ann Arbor, Michigan 48109, United States.
ORCID: 0000-0001-8334-3647

Ching-Kuo Lee (CK)

School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.

Clay C C Wang (CCC)

Department of Pharmacology and Pharmaceutical Sciences, Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90089, United States.
Department of Chemistry, Dornsife College of Letters, Arts, and Sciences, University of Southern California, Los Angeles, California 90089, United States.
ORCID: 0000-0003-2955-7569

Berl R Oakley (BR)

Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045, United States.
ORCID: 0000-0002-3046-8240

Classifications MeSH