Germline
Humans
DNA Repair
/ genetics
Tumor Suppressor Proteins
/ genetics
Germ-Line Mutation
Ubiquitin-Protein Ligases
/ genetics
Mesothelioma
/ genetics
Genetic Predisposition to Disease
Calcium Signaling
/ genetics
Female
Male
Middle Aged
Tumor Suppressor Protein p53
/ genetics
Apoptosis
/ genetics
Fibroblasts
/ metabolism
Asbestos
/ toxicity
Genomic Instability
cancer prevention
carcinogenesis
gene × environment
genetics
mesothelioma
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
16 Jul 2024
16 Jul 2024
Historique:
medline:
11
7
2024
pubmed:
11
7
2024
entrez:
11
7
2024
Statut:
ppublish
Résumé
We report that ~1.8% of all mesothelioma patients and 4.9% of those younger than 55, carry rare germline variants of the BRCA1 associated RING domain 1 (
Identifiants
pubmed: 38990952
doi: 10.1073/pnas.2405231121
doi:
Substances chimiques
BARD1 protein, human
EC 2.3.2.27
Tumor Suppressor Proteins
0
Ubiquitin-Protein Ligases
EC 2.3.2.27
Tumor Suppressor Protein p53
0
Asbestos
1332-21-4
TP53 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2405231121Subventions
Organisme : HHS | NIH | National Institute of Environmental Health Sciences (NIEHS)
ID : 1R01ES030948-01
Organisme : HHS | NIH | National Cancer Institute (NCI)
ID : 1R01CA237235-01A1
Organisme : US Department of Defence
ID : 1R01CA198138
Organisme : the Early Detection Research Network NCI
ID : 5U01CA214195-04
Organisme : Italian Association for Cancer Research
ID : IG-23670
Organisme : Italian Association for Cancer Research
ID : IG-19803
Organisme : AROSE, Progetti di Rilevante Interesse Nazionale
ID : PRIN2017E5L5P3 t
Organisme : AROSE, Progetti di Rilevante Interesse Nazionale
ID : PRIN20177E9EPY
Organisme : Italian Ministry of Health
ID : GR-2013-02356747
Organisme : European Research Council
ID : 853057
Pays : International
Organisme : NSF
ID : PHY-2019745
Organisme : Welch Foundation (The Welch Foundation)
ID : C-1792
Déclaration de conflit d'intérêts
Competing interests statement:M.C. has a patent issued for “Methods for Diagnosing a Predisposition to Develop Cancer.” M.C. and H.Y. have a patent issued for “Using Anti-HMGB1 Monoclonal Antibody or other HMGB1 Antibodies as a Novel Mesothelioma Therapeutic Strategy”, and a patent issued for “HMGB1 As a Biomarker for Asbestos Exposure and Mesothelioma Early Detection.” M.C. is a board-certified pathologist who provides consultation for pleural pathology, including medical-legal.