Aortic root dilation in acromegaly.


Journal

BMJ case reports
ISSN: 1757-790X
Titre abrégé: BMJ Case Rep
Pays: England
ID NLM: 101526291

Informations de publication

Date de publication:
10 Jul 2024
Historique:
medline: 12 7 2024
pubmed: 12 7 2024
entrez: 11 7 2024
Statut: epublish

Résumé

Previous studies have linked persistent elevations in growth hormone (GH) and insulin-like growth factor-1 (IGF-1) to cardiac abnormalities including aortic root dilation. Guidelines in the management of this dilation below the size recommended for surgery have not been well defined but follow-up and intervention when appropriate could be life-saving. We report the case of a man in his 60s who had been living with undiagnosed acromegaly for many years. His initial assessment through point-of-care ultrasound raised concerns about potential cardiac enlargement, prompting further investigation with a formal echocardiogram, which revealed a significant aortic root dilation measuring 4.5 cm. Subsequent blood tests confirmed elevated levels of IGF-1. Brain MRI showed a focal lesion in the pituitary gland, which was surgically resected, confirming the diagnosis of a GH-secreting pituitary adenoma. One year after surgery, a repeat CT angiogram of the chest demonstrated a stable size of the aortic root aneurysm.

Identifiants

pubmed: 38991564
pii: 17/7/e260204
doi: 10.1136/bcr-2024-260204
pii:
doi:

Substances chimiques

Insulin-Like Growth Factor I 67763-96-6

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© BMJ Publishing Group Limited 2024. No commercial re-use. See rights and permissions. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: None declared.

Auteurs

Yvette Ayewa Yeboah-Kordieh (YA)

Internal Medicine, MedStar Union Memorial Hospital, Baltimore, Maryland, USA yvetteeliza93@gmail.com.

Waqar Arif (W)

Department of Pathology, Johns Hopkins Medicine, Baltimore, Maryland, USA.

David Weisman (D)

Internal Medicine, MedStar Union Memorial Hospital, Baltimore, Maryland, USA.

Roberto Salvatori (R)

Johns Hopkins Pituitary Center, Johns Hopkins Medicine, Baltimore, Maryland, USA.

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Classifications MeSH