Associations between 25 hydroxyvitamin D concentration and spontaneous abortion.

Humans Female Abortion, Spontaneous / epidemiology Vitamin D / blood Retrospective Studies Pregnancy Mendelian Randomization Analysis Adult Genome-Wide Association Study
Abortion Mendelian randomization Vitamin D

Journal

BMC public health
ISSN: 1471-2458
Titre abrégé: BMC Public Health
Pays: England
ID NLM: 100968562

Informations de publication

Date de publication:
11 Jul 2024
Historique:
received: 13 09 2022
accepted: 07 06 2024
medline: 12 7 2024
pubmed: 12 7 2024
entrez: 11 7 2024
Statut: epublish

Résumé

Spontaneous abortion is a common complication of pregnancy that can lead to adverse physical and psychological outcomes for women. Vitamin D is reported to be associated with reproductive functions, whereas its casual effects on abortion remains unclear. In this study, a two-sample Mendelian randomization (MR) analysis was performed to systematically assess the causal relationships between serum 25 hydroxyvitamin D [25(OH)D] concentration and the risk of spontaneous abortion. GWAS summary data of 25(OH)D were used as exposure, and data of spontaneous abortion was considered as outcome. A retrospective study was additionally conducted to verify the MR results. MR estimates showed that a higher 25(OH)D level was potentially associated with decreased risk of spontaneous abortion (IVW, OR = 0.98, 95%CI = 0.90-1.06; MR Egger, OR = 0.94, 95%CI = 0.84-1.05; Weighted median, OR = 0.93, 95%CI = 0.82-1.06; Weighted mode, OR = 0.93, 95%CI = 0.84-1.03), though the P-value was not statistically significant. The retrospective study also produced consistent result of Vitamin D's protective role to spontaneous abortion. The P-value was very close to statistical significance (P = 0.053). This study reports the potential protective role of serum 25(OH)D concentration to spontaneous abortion, suggesting that increased vitamin D levels may decrease the risk of abortion. Further larger prospective studies and/or even randomized controlled trials are needed to confirm causal relationship between vitamin D and abortion.

Sections du résumé

BACKGROUND BACKGROUND
Spontaneous abortion is a common complication of pregnancy that can lead to adverse physical and psychological outcomes for women. Vitamin D is reported to be associated with reproductive functions, whereas its casual effects on abortion remains unclear.
MATERIALS AND METHODS METHODS
In this study, a two-sample Mendelian randomization (MR) analysis was performed to systematically assess the causal relationships between serum 25 hydroxyvitamin D [25(OH)D] concentration and the risk of spontaneous abortion. GWAS summary data of 25(OH)D were used as exposure, and data of spontaneous abortion was considered as outcome. A retrospective study was additionally conducted to verify the MR results.
RESULTS RESULTS
MR estimates showed that a higher 25(OH)D level was potentially associated with decreased risk of spontaneous abortion (IVW, OR = 0.98, 95%CI = 0.90-1.06; MR Egger, OR = 0.94, 95%CI = 0.84-1.05; Weighted median, OR = 0.93, 95%CI = 0.82-1.06; Weighted mode, OR = 0.93, 95%CI = 0.84-1.03), though the P-value was not statistically significant. The retrospective study also produced consistent result of Vitamin D's protective role to spontaneous abortion. The P-value was very close to statistical significance (P = 0.053).
CONCLUSIONS CONCLUSIONS
This study reports the potential protective role of serum 25(OH)D concentration to spontaneous abortion, suggesting that increased vitamin D levels may decrease the risk of abortion. Further larger prospective studies and/or even randomized controlled trials are needed to confirm causal relationship between vitamin D and abortion.

Identifiants

DOI: 10.1186/s12889-024-19078-5 PMID: 38992645
pubmed: 38992645
doi: 10.1186/s12889-024-19078-5
pii: 10.1186/s12889-024-19078-5
doi:

Substances chimiques

Vitamin D 1406-16-2
25-hydroxyvitamin D A288AR3C9H

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1858

Subventions

Organisme : Zhejiang Provincial Natural Science Foundation (LQ21H040008), Zhejiang Provincial Science and Technology Bureau Foundation (LGF22H040010), the Fundamental Scientific Research Project of Wenzhou (Y20210018), the Medical Health Science and Technology Project of Zhejiang Provincial (2022KY1207), and the Science and Technology Planning Project of Wenzhou (ZY2021025).
ID : LQ21H040008, Y20210018, 2022KY1207,ZY2021025.
Organisme : Zhejiang Provincial Natural Science Foundation (LQ21H040008), Zhejiang Provincial Science and Technology Bureau Foundation (LGF22H040010), the Fundamental Scientific Research Project of Wenzhou (Y20210018), the Medical Health Science and Technology Project of Zhejiang Provincial (2022KY1207), and the Science and Technology Planning Project of Wenzhou (ZY2021025).
ID : LQ21H040008, Y20210018, 2022KY1207,ZY2021025.
Organisme : Zhejiang Provincial Natural Science Foundation (LQ21H040008), Zhejiang Provincial Science and Technology Bureau Foundation (LGF22H040010), the Fundamental Scientific Research Project of Wenzhou (Y20210018), the Medical Health Science and Technology Project of Zhejiang Provincial (2022KY1207), and the Science and Technology Planning Project of Wenzhou (ZY2021025).
ID : LQ21H040008, Y20210018, 2022KY1207,ZY2021025.
Organisme : Zhejiang Provincial Natural Science Foundation (LQ21H040008), Zhejiang Provincial Science and Technology Bureau Foundation (LGF22H040010), the Fundamental Scientific Research Project of Wenzhou (Y20210018), the Medical Health Science and Technology Project of Zhejiang Provincial (2022KY1207), and the Science and Technology Planning Project of Wenzhou (ZY2021025).
ID : LQ21H040008, Y20210018, 2022KY1207,ZY2021025.
Organisme : Zhejiang Provincial Clinical Research Center for Pediatric Disease
ID : 2022E50003

Informations de copyright

© 2024. The Author(s).

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Auteurs

Hongping Zhang (H)

Department of Obstetrics and Gynecology, Wenzhou People's Hospital, Wenzhou Maternal and Child Health Care Hospital, The Third Clinical Institute Affiliated to Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou, China.

Xingru Ding (X)

Zhejiang Provincial Clinical Research Center for Pediatric Disease, The Second School of Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Xianqing Hu (X)

Department of Obstetrics and Gynecology, Wenzhou People's Hospital, Wenzhou Maternal and Child Health Care Hospital, The Third Clinical Institute Affiliated to Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou, China.

Yi-Xin Cai (YX)

Zhejiang Provincial Clinical Research Center for Pediatric Disease, The Second School of Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Haiying Chen (H)

Department of Obstetrics and Gynecology, Wenzhou People's Hospital, Wenzhou Maternal and Child Health Care Hospital, The Third Clinical Institute Affiliated to Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou, China.

Congcong Sun (C)

Department of Scientific Research Center, Wenzhou People's Hospital, Wenzhou Maternal and Child Health Care Hospital, The Third Clinical Institute Affiliated to Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou, China.

Jingjing Chen (J)

Department of Obstetrics and Gynecology, Wenzhou People's Hospital, Wenzhou Maternal and Child Health Care Hospital, The Third Clinical Institute Affiliated to Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou, China.

Xiaoqing Li (X)

Department of Scientific Research Center, Wenzhou People's Hospital, Wenzhou Maternal and Child Health Care Hospital, The Third Clinical Institute Affiliated to Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou, China.

Zhenzhen Zheng (Z)

Department of Obstetrics and Gynecology, Wenzhou People's Hospital, Wenzhou Maternal and Child Health Care Hospital, The Third Clinical Institute Affiliated to Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou, China.

Tingting Liao (T)

Department of Obstetrics and Gynecology, Wenzhou People's Hospital, Wenzhou Maternal and Child Health Care Hospital, The Third Clinical Institute Affiliated to Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou, China.

Na Zhao (N)

Department of Obstetrics and Gynecology, Wenzhou People's Hospital, Wenzhou Maternal and Child Health Care Hospital, The Third Clinical Institute Affiliated to Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou, China.

Mingchen Zhong (M)

Department of Scientific Research Center, Wenzhou People's Hospital, Wenzhou Maternal and Child Health Care Hospital, The Third Clinical Institute Affiliated to Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou, China.

Rujing Fang (R)

Department of Obstetrics and Gynecology, Wenzhou People's Hospital, Wenzhou Maternal and Child Health Care Hospital, The Third Clinical Institute Affiliated to Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou, China.

Xiu-Feng Huang (XF)

Zhejiang Provincial Clinical Research Center for Pediatric Disease, The Second School of Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. hxfwzmc@163.com.

Jianqiong Zheng (J)

Department of Obstetrics and Gynecology, Wenzhou People's Hospital, Wenzhou Maternal and Child Health Care Hospital, The Third Clinical Institute Affiliated to Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou, China. zjq1980120@163.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Associations between 25 hydroxyvitamin D...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Issue de la grossesse › Avortement spontané › Associations between 25 hydroxyvitamin D...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Sécostéroïdes › Vitamine D › Associations between 25 hydroxyvitamin D...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Associations between 25 hydroxyvitamin D...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Associations between 25 hydroxyvitamin D...
questionsmedicales.fr › Techniques d'investigation › Analyse de randomisation mendélienne › Associations between 25 hydroxyvitamin D...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Associations between 25 hydroxyvitamin D...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Associations between 25 hydroxyvitamin D...