A high-throughput approach to identify BRCA1-downregulating compounds to enhance PARP inhibitor sensitivity.

Cancer Cell biology Pharmacology

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
19 Jul 2024
Historique:
received: 09 11 2023
revised: 29 04 2024
accepted: 01 06 2024
medline: 12 7 2024
pubmed: 12 7 2024
entrez: 12 7 2024
Statut: epublish

Résumé

PARP inhibitors (PARPi) are efficacious in

Identifiants

DOI: 10.1016/j.isci.2024.110180 PMID: 38993666 PMC: PMC11238136
pubmed: 38993666
doi: 10.1016/j.isci.2024.110180
pii: S2589-0042(24)01405-6
pmc: PMC11238136
doi:

Types de publication

Journal Article

Langues

eng

Pagination

110180

Informations de copyright

© 2024 The Author(s).

Déclaration de conflit d'intérêts

The authors have no competing interests to disclose.

Auteurs

Erin Sellars (E)

Department of Pharmacology & Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Women's College Research Institute, Women's College Hospital, Toronto, ON M5S 1B2, Canada.

Margarita Savguira (M)

Department of Pharmacology & Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada.

Jie Wu (J)

Department of Pharmacology & Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada.

Sabrina Cancelliere (S)

Department of Pharmacology & Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada.

Mark Jen (M)

Lunenfeld-Tanenbaum Research Institute, Network Biology Collaborative Centre, High-Throughput Screening, Mt. Sinai Hospital, Sinai Health System, Toronto, ON M5G 1X5, Canada.

Rehna Krishnan (R)

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.

Anne Hakem (A)

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.

Dalia Barsyte-Lovejoy (D)

Department of Pharmacology & Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.

Razqallah Hakem (R)

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.
Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.

Steven A Narod (SA)

Women's College Research Institute, Women's College Hospital, Toronto, ON M5S 1B2, Canada.
Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5T 3M7, Canada.

Joanne Kotsopoulos (J)

Department of Pharmacology & Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Women's College Research Institute, Women's College Hospital, Toronto, ON M5S 1B2, Canada.
Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5T 3M7, Canada.

Leonardo Salmena (L)

Department of Pharmacology & Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Women's College Research Institute, Women's College Hospital, Toronto, ON M5S 1B2, Canada.

Classifications MeSH