Interactions of TTV with BKV, CMV, EBV, and HHV-6A and their impact on post-transplant graft function in kidney transplant recipients.

Background

Mono and combined reactivation of latent viruses occurs frequently under immunosuppressive therapy in kidney transplant patients. Recently, monitoring torque teno virus (TTV) reactivation came more into focus as a potential biomarker for immune status. The surrogate characteristics of TTV reactivation on acute rejection, and the combined reactivation with other latent viruses such as cytomegalovirus (CMV), human BK virus (BKV), Epstein-Barr virus (EBV), and human herpes virus-6A (HHV-6A) on allograft function, are unknown so far.

Methods

Blood samples from 93 kidney transplant recipients obtained during the first post-transplant year were analyzed for TTV/BKV/CMV/EBV/HHV-6A load. Clinical characteristics, including graft function [glomerular filtration rate (GFR)], were collected in parallel.

Results

TTV had the highest prevalence and viral loads at 100% and a mean of 5.72 copies/ml (cp/ml) (log

Conclusion

We were able to observe and support previously introduced TTV load thresholds predicting kidney allograft rejection. However, due to a possible delayed relation between immunosuppressive medication and TTV viral load adaptation, the right time points to start using TTV as a biomarker might need to be further clarified by other and better designed studies.

Informations de copyright

© 2024 Rosiewicz, Blazquez-Navarro, Kaliszczyk, Bauer, Or-Guil, Viebahn, Zgoura, Reinke, Roch, Hugo, Westhoff, Thieme, Stervbo and Babel.

Déclaration de conflit d'intérêts

CB was employed by MicroDiscovery GmbH. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. PR and NB declared that they were editorial board members of Frontiers at the time of submission. This had no impact on the peer review process and the final decision.