Physical Activity and Health-related Quality of Life from Diagnosis to One Year After Radical Cystectomy in Patients with Bladder Cancer: A Longitudinal Cohort Study.
Urinary bladder neoplasms
cystectomy
exercise
longitudinal studies
patient reported outcome measures
preoperative exercise
quality of life
rehabilitation
Journal
Bladder cancer (Amsterdam, Netherlands)
ISSN: 2352-3735
Titre abrégé: Bladder Cancer
Pays: Netherlands
ID NLM: 101668567
Informations de publication
Date de publication:
2022
2022
Historique:
received:
10
09
2021
accepted:
31
07
2022
medline:
14
12
2022
pubmed:
14
12
2022
entrez:
12
7
2024
Statut:
epublish
Résumé
Emerging evidence shows a positive impact of physical activity (PA) on health-related quality of life (HRQoL) in cancer patients. However, longitudinal evidence on PA and HRQoL in patients with bladder cancer (BC) undergoing radical cystectomy (RC) is lacking. To investigate PA levels, HRQoL outcomes and their relationship from diagnosis to one year after RC in BC patients. A longitudinal cohort study in 90 BC patients was conducted at Ghent and Leuven University Hospitals between April 2017 and December 2020. The Godin Leisure-Time Exercise Questionnaire (GLTEQ) and the EORTC QLQ-C30 and BLM30 were used to measure PA and HRQoL, respectively, before RC, one, three, six and twelve months after RC. Linear mixed models were used for statistical analyses. The majority was physically inactive before RC (58%), at month one (79%), three (53%), six (61%) and twelve (64%). Among (moderately) active patients, light-intensity activities (mainly walking) were important contributors to the total amount of PA. Clinically important and low HRQoL outcomes in different domains were identified with lowest scores at diagnosis and one month after RC. Active patients before RC have better physical functioning (mean difference (MD) -22.7, standard error (SE) 8.7, Higher PA levels are associated with better HRQoL outcomes for BC patients undergoing RC. The data suggests that PA interventions could be an asset to improve BC patients' HRQoL, but should be tested in future trials.
Sections du résumé
BACKGROUND
BACKGROUND
Emerging evidence shows a positive impact of physical activity (PA) on health-related quality of life (HRQoL) in cancer patients. However, longitudinal evidence on PA and HRQoL in patients with bladder cancer (BC) undergoing radical cystectomy (RC) is lacking.
OBJECTIVES
OBJECTIVE
To investigate PA levels, HRQoL outcomes and their relationship from diagnosis to one year after RC in BC patients.
METHODS
METHODS
A longitudinal cohort study in 90 BC patients was conducted at Ghent and Leuven University Hospitals between April 2017 and December 2020. The Godin Leisure-Time Exercise Questionnaire (GLTEQ) and the EORTC QLQ-C30 and BLM30 were used to measure PA and HRQoL, respectively, before RC, one, three, six and twelve months after RC. Linear mixed models were used for statistical analyses.
RESULTS
RESULTS
The majority was physically inactive before RC (58%), at month one (79%), three (53%), six (61%) and twelve (64%). Among (moderately) active patients, light-intensity activities (mainly walking) were important contributors to the total amount of PA. Clinically important and low HRQoL outcomes in different domains were identified with lowest scores at diagnosis and one month after RC. Active patients before RC have better physical functioning (mean difference (MD) -22.7, standard error (SE) 8.7,
CONCLUSIONS
CONCLUSIONS
Higher PA levels are associated with better HRQoL outcomes for BC patients undergoing RC. The data suggests that PA interventions could be an asset to improve BC patients' HRQoL, but should be tested in future trials.
Identifiants
pubmed: 38994185
doi: 10.3233/BLC-211607
pii: BLC211607
pmc: PMC11181764
doi:
Types de publication
Journal Article
Langues
eng
Pagination
395-404Informations de copyright
© 2022 – The authors. Published by IOS Press.
Déclaration de conflit d'intérêts
No conflict of interest to report by ER, AVH, JVC, KD, LP, BR, RB, MA, SV, MVH, RC, BD, and VF.