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Detecting genomic alterations (GAs) in advanced urothelial carcinoma (aUC) can expand treatment options by identifying candidates for targeted therapies. Erdafitinib is FDA-approved for patients with platinum-refractory aUC with activating mutation or fusion in

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Petros Grivas MD PhD reports grants and consulting/advisory board involvement from AstraZeneca, Bayer, Bristol-Myers Squibb, Clovis Oncology, GlaxoSmithKline, Genentech, Immunomedics, Merck, Mirati Therapeutics, Pfizer, and QED Therapeutics; grants from Bavarian Nordic, Debiopharm, Kure It Cancer Research, and Oncogenex; and consulting/advisory board involvement from Driver, Dyania Health, EMD Serono, Exelixis, Foundation Medicine, Genzyme, Heron Therapeutics, Janssen, Roche, and Seattle Genetics, outside the submitted work. Lesli A. Kiedrowski MS MPH reports employment and stock ownership from Guardant Health during the conduct of the study. Guru P. Sonpavde MD reports grants, personal fees, non-financial support, and advisory board/com-mittee involvement from AstraZeneca; grants and advisory board/committee involvement from Sanofi; non-financial support and advisory board/committee involvement from Bristol-Meyers Squibb; personal fees and advisory board/committee involvement from EMD Serono; advisory board/committee involvement from Genentech, Merck, Seattle Genetics, Astellas, Exelixis, Janssen, Bicycle Therapeutics, Pfizer, Bavarian Nordic, and QED; and personal fees from Physicians Education Resource, Onclive, Research to Practice, Medscape, Up To Date, Elsevier, and Debiopharm, outside the submitted work. Sumati V. Gupta MD reports grants and non-financial support from QED; grants from BMS, Rexahn, Incyte, Novartis, LSK, Five Prime, Mirati, Debiopharm, Merck, Pfizer, AstraZeneca, MedImmune, Clovis, and Daiichi Sankyo; and spouse stock ownership in Salarius Pharmaceuticals, outside the submitted work. Roby A. Thomas MD reports personal fees and advisory board involvement from Integra Connect, outside the submitted work. Theodore S. Gourdin MD reports grants from Ferring Pharmaceuticals and advisory board involvement from EMD Serono and Exelixis, outside the submitted work. Aaron I. Hardin PhD reports employment and stock ownership from Guardant Health during the conduct of the study. Kimberly M. Hamann MS reports employment and stock ownership from Guardant Health during the conduct of the study. Bishoy M. Faltas MD reports grants from Eli Lilly and personal fees from Immunomedics, Merck, and Urotoday, outside the submitted work. Nicholas J. Vogelzang MD reports personal fees, non-financial support, and advisory board/consulting involvement from Bayer, Genentech, and Pfizer; non-financial support and advisory board/consulting involvement from AstraZeneca; personal fees and advisory board/consulting involvement from Astellas and Clovis; personal fees and non-financial support from Sanofi; grants and non-financial support from US Oncology; advisory board/consulting involvement and stock ownership from Caris Life Sciences; grants and advisory board/consulting involvement from Merck; grants from Endocyte and Suzhou Kintor; personal fees from Bristol-Meyers Squibb, Novartis, Seattle Genetics, and Up To Date; and non-financial support from Exelixis, MedImmune, and Onyx, outside the submitted work.