Ambient Moisture-Driven Self-Powered Iontophoresis Patch for Enhanced Transdermal Drug Delivery.
iontophoresis
moist‐electric generator
self‐powered energy source
transdermal drug delivery
wearable patch
Journal
Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613
Informations de publication
Date de publication:
12 Jul 2024
12 Jul 2024
Historique:
revised:
25
06
2024
received:
15
04
2024
medline:
12
7
2024
pubmed:
12
7
2024
entrez:
12
7
2024
Statut:
aheadofprint
Résumé
Iontophoretic transdermal drug delivery (TDD) devices are known to enhance the transdermal transport of drugs. However, conventional transdermal iontophoretic devices require external power sources, wired connections, or mechanical parts, which reduce the comfort level for patients during extended use. In this work, a self-powered, wearable transdermal iontophoretic patch (TIP) is proposed by harvesting ambient humidity for energy generation, enabling controlled TDD. This patch primarily uses moist-electric generators (MEGs) as its power source, thus obviating the need for complex power management modules and mechanical components. A single MEG unit can produce an open-circuit voltage of 0.80 V and a short-circuit current of 11.65 µA under the condition of 80% relative humidity. Amplification of the electrical output is feasible by connecting multiple generator units in series and parallel, facilitating the powering of certain commercial electronic devices. Subsequently, the MEG array is integrated with the TDD circuit to create the wearable TIP. After 20 min of application, the depth of drug penetration through the skin is observed to increase threefold. The effective promotion effect of TIP on the transdermal delivery of ionized drugs is corroborated by simulations and experiments. This wearable TIP offers a simple, noninvasive solution for TDD.
Identifiants
pubmed: 38994663
doi: 10.1002/adhm.202401371
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2401371Subventions
Organisme : National Natural Science Foundation of China
ID : 12072096
Organisme : National Natural Science Foundation of China
ID : 12372260
Organisme : National Natural Science Foundation of China
ID : 12172064
Organisme : Interdisciplinary Research Foundation of HIT
ID : IR2021229
Organisme : Dianzi Foundation of HIT
ID : HIT.DZJJ.2023066
Informations de copyright
© 2024 Wiley‐VCH GmbH.
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