Hypoxia Promotes Invadosome Formation by Lung Fibroblasts.
Humans
Fibroblasts
/ metabolism
Lung
/ pathology
Podosomes
/ metabolism
Signal Transduction
Receptors, Lysophosphatidic Acid
/ metabolism
Idiopathic Pulmonary Fibrosis
/ pathology
Cell Hypoxia
Lysophospholipids
/ metabolism
Indoles
/ pharmacology
Proto-Oncogene Proteins c-akt
/ metabolism
Receptors, Platelet-Derived Growth Factor
/ metabolism
LPA1
fibroblasts
hypoxia 2
idiopathic pulmonary fibrosis
invadosomes LPA
nintedanib
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
06 Jul 2024
06 Jul 2024
Historique:
received:
21
06
2024
accepted:
02
07
2024
medline:
12
7
2024
pubmed:
12
7
2024
entrez:
12
7
2024
Statut:
epublish
Résumé
Lung parenchymal hypoxia has emerged as a cardinal feature of idiopathic pulmonary fibrosis (IPF). Hypoxia promotes cancer cell invasion and metastasis through signaling that is dependent upon the lysophosphatidic acid (LPA) receptor, LPA
Identifiants
pubmed: 38995003
pii: cells13131152
doi: 10.3390/cells13131152
pii:
doi:
Substances chimiques
Receptors, Lysophosphatidic Acid
0
Lysophospholipids
0
lysophosphatidic acid
PG6M3969SG
Indoles
0
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
nintedanib
G6HRD2P839
Receptors, Platelet-Derived Growth Factor
EC 2.7.10.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Boehringer-Ingelheim BUILD research program
ID : CRC #2018-2437
Organisme : CIHR
ID : RS-324683
Pays : Canada