A Prospective Observational Study of Renal Involvement in Hematological Malignancies.
Journal
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia
ISSN: 1319-2442
Titre abrégé: Saudi J Kidney Dis Transpl
Pays: Saudi Arabia
ID NLM: 9436968
Informations de publication
Date de publication:
01 Dec 2023
01 Dec 2023
Historique:
medline:
12
7
2024
pubmed:
12
7
2024
entrez:
12
7
2024
Statut:
ppublish
Résumé
Patients with hematological malignancies (HMs) are at high risk of infections and comorbidities that substantially increase the occurrence of renal failure. Thus, the management of renal dysfunction in patients with HMs is crucial. The current study aimed to determine the incidence of renal involvement in patients with HMs and analyze their clinical profile in the context of renal disorders. A prospective observational study was conducted on 200 patients suffering from various HMs. Renal involvement was determined through blood and urine analyses. The mean age of the patients was 51.84 ± 17.47 years, with the male-to-female ratio being 1.5:1. Multiple myeloma (MM) (30.5%) and non-Hodgkin's lymphoma (NHL) (30.5%) were the most commonly observed types of HM, whereas plasmacytoma (1%) was the least observed. Moreover, 39.5% and 16.5% of patients were diagnosed with moderate and severe anemia, respectively. Mean calcium, creatinine, and blood urea nitrogen levels were 8.97 ± 1.19 mg/dL, 1.41 ± 1.37 mg/dL, and 16.83 ± 14.50 mg/dL, respectively. Mean sodium, potassium, and uric acid levels were 135.49 ± 6.79 mEq/L, 4.157 ± 0.65 mEq/L, and 5.81 ± 2.82 mg/dL, respectively. Twelve percent of the patients (24 out of 200) presented with renal insufficiency and nephrotic syndrome. Ten patients were diagnosed with NHL, 10 patients with MM, two with chronic myeloid leukemia, and two with acute myeloid leukemia. The causes of renal impairment in most cases were patchy interstitial lymphoid infiltrates, cast nephropathy, acute tubular necrosis, and minimal change disease.
Identifiants
pubmed: 38995278
doi: 10.4103/sjkdt.sjkdt_66_22
pii: 00936703-202307001-00011
doi:
Types de publication
Observational Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
S103-S111Informations de copyright
Copyright © 2023 Copyright: © 2023 Saudi Journal of Kidney Diseases and Transplantation.
Références
Nikethan D. Clinical study and analysis of kidney disease in patients with hematological malignancies. Int J Sci Study 2019;7:66-71.
Chuva T, Maximino J, Barbosa J, et al. Haematological malignancies and acute kidney injury requiring nephrology consultation: Challenging the worst of the worst. Clin Kidney J 2016;9:418-23.
Banday KA, Sirwal IA, Reshi AR, Najar MS, Bhat MA, Wani MM. Renal involvement in hematologic neoplasia. Indian J Nephrol 2004;14:50-2.
Ganguli A, Sawinski D, Berns JS. Kidney diseases associated with haematological cancers. Nat Rev Nephrol 2015;11:478-90.
Canet E, Zafrani L, Lambert J, et al. Acute kidney injury in patients with newly diagnosed high-grade hematological malignancies: Impact on remission and survival. PLoS One 2013;8:e55870.
van Vliet M, Verburg IW, van den Boogaard M, et al. Trends in admission prevalence, illness severity and survival of haematological patients treated in Dutch intensive care units. Intensive Care Med 2014;40:1275-84.
Cohen LJ, Rennke HG, Laubach JP, Humphreys BD. The spectrum of kidney involvement in lymphoma: A case report and review of the literature. Am J Kidney Dis 2010;56:1191-6.
Li SJ, Chen HP, Chen YH, Zhang LH, Tu YM, Liu ZH. Renal involvement in non-Hodgkin lymphoma: Proven by renal biopsy. PLoS One 2014;9:e95190.
Besson C, Gonin C, Brebion A, Delaunay C, Panelatti G, Plumelle Y. Incidence of hemato-logical malignancies in Martinique, French West Indies, overrepresentation of multiple myeloma and adult T cell leukemia/lymphoma. Leukemia 2001;15:828-31.
Ferraz Gonçalves JA, Costa T, Rema J, et al. Hypocalcemia in cancer patients: An exploratory study. Porto Biomed J 2019;4:e45.
Refeno V, Hasiniatsy NR, Ramahandrisoa AV, Rakoto FA, Alson AO, Rafaramino F. Epidemiology and clinical aspects of hematological malignancies at the military hospital of Antananarivo. Int J Res Med Sci 2019;7:2037-44.
Makkar V, Puri S, Mehta S, Bery A, Sandhu J, Sekhon J. Analyzing renal involvement in 100 cases of hematological malignancy. Int J Med Sci Public Health 2015;4:486-92.
Brown LM, Linet MS, Greenberg RS, et al. Multiple myeloma and family history of cancer among blacks and whites in the U.S. Cancer 1999;85:2385-90.
Ajithkumar K, Ramalingam S, Kannangai R, Prakash KJ. Human T lymphotrophic virus-I (HTLV-I) infection in patients with unclassy-fiable dermatitis in central Kerala, South India: A preliminary study. Sex Transm Infect 2002;78:E7.
Roy M, Das MK, Ishida T, et al. Absence of HTLV-I infection in some Indian populations. Indian J Med Res 1994;100:160-2.
Malhotra VL, Lakshmy A. HTLV-I in HIV seropositive Indian blood donors. J Commun Dis 1996;28:270-2.
Groves FD, Linet MS, Travis LB, Devesa SS. Cancer surveillance series: Non-Hodgkin's lymphoma incidence by histologic subtype in the United States from 1978 through 1995. J Natl Cancer Inst 2000;92:1240-51.
Jin J, Wang Y, Shen Q, Gong J, Zhao L, He Q. Acute kidney injury in cancer patients: A nationwide survey in China. Sci Rep 2019;9:3540.
Manapuram S, Hashmi H. Treatment of multiple myeloma in elderly patients: A review of literature and practice guidelines. Cureus 2018;10:e3669.
Purysko AS, Westphalen AC, Remer EM, Coppa CP, Leão Filho HM, Herts BR. Imaging manifestations of hematologic diseases with renal and perinephric involvement. Radiographics 2016;36:1038-54.
Wanchoo R, Bernabe Ramirez C, Barrientos J, Jhaveri KD. Renal involvement in chronic lymphocytic leukemia. Clin Kidney J 2018;11:670-80.
Soleymanian T, Soleimani A, Musavi A, Mojtahedi K, Hamid G. Outcome of patients with multiple myeloma and renal failure on novel regimens. Saudi J Kidney Dis Transpl 2016;27:335-40.
Luciano RL, Brewster UC. Kidney involvement in leukemia and lymphoma. Adv Chronic Kidney Dis 2014;21:27-35.
Yamauchi T, Negoro E, Lee S, et al. A high serum uric acid level is associated with poor prognosis in patients with acute myeloid leukemia. Anticancer Res 2013;33:3947-51.