A Case Report of Fibrillary Glomerulonephritis with Mild Albuminuria: A Viewpoint on Proteomics.
Journal
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia
ISSN: 1319-2442
Titre abrégé: Saudi J Kidney Dis Transpl
Pays: Saudi Arabia
ID NLM: 9436968
Informations de publication
Date de publication:
01 Sep 2023
01 Sep 2023
Historique:
medline:
12
7
2024
pubmed:
12
7
2024
entrez:
12
7
2024
Statut:
ppublish
Résumé
Fibrillary glomerulonephritis (FGN) is a rare glomerular disorder characterized by the deposition of randomly arranged fibrils in the mesangium and the glomerular basement membrane. Clinical features include massive albuminuria, hematuria, high blood pressure, and kidney failure. Usually, the renal prognosis is not favorable, with evolution to end-stage renal disease in approximately 50% of cases. Recent studies in proteomics have identified a member of the heat shock protein family, also called DNAJB9, which is deposited in the glomerulus of patients with FGN and is not present in other diseases, such as amyloidosis or immunotactoid glomerulopathy. These findings are the first step to clarify the pathogenesis of this disease and could facilitate its diagnosis. Hence, we present a case of FGN with mild albuminuria at baseline and discuss the usefulness of this novel biomarker for diagnosing this group of patients.
Identifiants
pubmed: 38995306
doi: 10.4103/1319-2442.397209
pii: 00936703-202334050-00011
doi:
Substances chimiques
DNAJB9 protein, human
0
Biomarkers
0
HSP40 Heat-Shock Proteins
0
Molecular Chaperones
0
Membrane Proteins
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
458-461Informations de copyright
Copyright © 2023 Copyright: © 2023 Saudi Journal of Kidney Diseases and Transplantation.
Références
Rosenstock JL, Markowitz GS, Valeri AM, Sacchi G, Appel GB, D'Agati VD. Fibrillary and immunotactoid glomerulonephritis: Distinct entities with different clinical and pathologic features. Kidney Int 2003;63:1450-61.
Nasr SH, Valeri AM, Cornell LD, et al. Fibrillary glomerulonephritis: A report of 66 cases from a single institution. Clin J Am Soc Nephrol 2011;6:775-84.
Javaugue V, Karras A, Glowacki F, et al. Longterm kidney disease outcomes in fibrillary glomerulonephritis: A case series of 27 patients. Am J Kidney Dis 2013;62:679-90.
Czarnecki PG, Lager DJ, Leung N, Dispenzieri A, Cosio FG, Fervenza FC. Long-term outcome of kidney transplantation in patients with fibrillary glomerulonephritis or monoclonal gammopathy with fibrillary deposits. Kidney Int 2009;75:420-7.
Shah HH, Thakkar J, Pullman JM, Mathew AT. Fibrillary glomerulonephritis presenting as crescentic glomerulonephritis. Indian J Nephrol 2017;27:157-60.
Thomas JA, Vasin D, Lin M, Anderson AE, Alpers CE. A case of mistaken identity: Fibrillary glomerulonephritis masquerading as crescentic anti-glomerular basement membrane disease. Clin Nephrol 2016;85:114-20.
Sethi S, Theis JD, Vrana JA, et al. Laser microdissection and proteomic analysis of amyloidosis, cryoglobulinemic GN, fibrillary GN, and immunotactoid glomerulopathy. Clin J Am Soc Nephrol 2013;8:915-21.
Dasari S, Alexander MP, Vrana JA, et al. DnaJ heat shock protein family B member 9 is a novel biomarker for fibrillary GN. J Am Soc Nephrol 2018;29:51-6.