Clipping the Positive Lymph Node in Patients with Clinically Node Positive Breast Cancer Treated with Neoadjuvant Chemotherapy: Impact on Axillary Surgery in the ISPY-2 Clinical Trial.

Breast cancer Clipped node Neoadjuvant chemotherapy Sentinel lymph node surgery Targeted axillary dissection

Journal

Annals of surgical oncology
ISSN: 1534-4681
Titre abrégé: Ann Surg Oncol
Pays: United States
ID NLM: 9420840

Informations de publication

Date de publication:
12 Jul 2024
Historique:
received: 11 04 2024
accepted: 24 06 2024
medline: 12 7 2024
pubmed: 12 7 2024
entrez: 12 7 2024
Statut: aheadofprint

Résumé

For patients with clinically node-positive (cN+) breast cancer undergoing neoadjuvant chemotherapy (NAC), retrieving previously clipped, biopsy-proven positive lymph nodes during sentinel lymph node biopsy [i.e., targeted axillary dissection (TAD)] may reduce false negative rates. However, the overall utilization and impact of clipping positive nodes remains uncertain. We retrospectively analyzed cN+ ISPY-2 patients (2011-2022) undergoing axillary surgery after NAC. We evaluated trends in node clipping and associations with type of axillary surgery [sentinel lymph node (SLN) only, SLN and axillary lymph node dissection (ALND), or ALND only] and event-free survival (EFS) in patients that were cN+ on a NAC trial. Among 801 cN+ patients, 161 (20.1%) had pre-NAC clip placement in the positive node. The proportion of patients that were cN+ undergoing clip placement increased from 2.4 to 36.2% between 2011 and 2021. Multivariable logistic regression showed nodal clipping was independently associated with higher odds of SLN-only surgery [odds ratio (OR) 4.3, 95% confidence interval (CI) 2.8-6.8, p < 0.001]. This was also true among patients with residual pathologically node-positive (pN+) disease. Completion ALND rate did not differ based on clip retrieval success. No significant differences in EFS were observed in those with or without clip placement, both with or without successful clip retrieval [hazard ratio (HR) 0.85, 95% CI 0.4-1.7, p = 0.7; HR 1.8, 95% CI 0.5-6.0, p = 0.3, respectively]. Clip placement in the positive lymph node before NAC is increasingly common. The significant association between clip placement and omission of axillary dissection, even among patients with pN+ disease, suggests a paradigm shift toward TAD as a definitive surgical management strategy in patients with pN+ disease after NAC.

Sections du résumé

BACKGROUND BACKGROUND
For patients with clinically node-positive (cN+) breast cancer undergoing neoadjuvant chemotherapy (NAC), retrieving previously clipped, biopsy-proven positive lymph nodes during sentinel lymph node biopsy [i.e., targeted axillary dissection (TAD)] may reduce false negative rates. However, the overall utilization and impact of clipping positive nodes remains uncertain.
PATIENTS AND METHODS METHODS
We retrospectively analyzed cN+ ISPY-2 patients (2011-2022) undergoing axillary surgery after NAC. We evaluated trends in node clipping and associations with type of axillary surgery [sentinel lymph node (SLN) only, SLN and axillary lymph node dissection (ALND), or ALND only] and event-free survival (EFS) in patients that were cN+ on a NAC trial.
RESULTS RESULTS
Among 801 cN+ patients, 161 (20.1%) had pre-NAC clip placement in the positive node. The proportion of patients that were cN+ undergoing clip placement increased from 2.4 to 36.2% between 2011 and 2021. Multivariable logistic regression showed nodal clipping was independently associated with higher odds of SLN-only surgery [odds ratio (OR) 4.3, 95% confidence interval (CI) 2.8-6.8, p < 0.001]. This was also true among patients with residual pathologically node-positive (pN+) disease. Completion ALND rate did not differ based on clip retrieval success. No significant differences in EFS were observed in those with or without clip placement, both with or without successful clip retrieval [hazard ratio (HR) 0.85, 95% CI 0.4-1.7, p = 0.7; HR 1.8, 95% CI 0.5-6.0, p = 0.3, respectively].
CONCLUSION CONCLUSIONS
Clip placement in the positive lymph node before NAC is increasingly common. The significant association between clip placement and omission of axillary dissection, even among patients with pN+ disease, suggests a paradigm shift toward TAD as a definitive surgical management strategy in patients with pN+ disease after NAC.

Identifiants

pubmed: 38995451
doi: 10.1245/s10434-024-15792-x
pii: 10.1245/s10434-024-15792-x
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

Références

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Auteurs

Kayla M Switalla (KM)

University of Minnesota Medical School, Minneapolis, MN, USA.
Department of Surgery, University of California San Francisco, San Francisco, CA, USA.

Judy C Boughey (JC)

Department of Surgery, Mayo Clinic, Rochester, MN, USA.

Katrina Dimitroff (K)

Quantum Leap Healthcare Collaborative, San Francisco, CA, USA.

Christina Yau (C)

Quantum Leap Healthcare Collaborative, San Francisco, CA, USA.

Velle Ladores (V)

Department of Surgery, University of California San Francisco, San Francisco, CA, USA.

Hongmei Yu (H)

Quantum Leap Healthcare Collaborative, San Francisco, CA, USA.

Julia Tchou (J)

Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA.

Mehra Golshan (M)

Department of Surgery, Yale School of Medicine, New Haven, CT, USA.

Gretchen Ahrendt (G)

Department of Surgery, University of Colorado, Aurora, CO, USA.

Lauren M Postlewait (LM)

Department of Surgery, Emory University, Atlanta, GA, USA.

Mara Piltin (M)

Department of Surgery, Mayo Clinic, Rochester, MN, USA.

Chantal R Reyna (CR)

Department of Surgery, Loyola University Medical Center, Chicago, IL, USA.

Cindy B Matsen (CB)

Department of Surgery, University of Utah, Salt Lake City, UT, USA.

Todd M Tuttle (TM)

Department of Surgery, University of Minnesota, Minneapolis, MN, USA.

Anne M Wallace (AM)

Department of Surgery, University of California San Diego, San Diego, CA, USA.

Cletus A Arciero (CA)

Department of Surgery, Emory University, Atlanta, GA, USA.

Marie Catherine Lee (MC)

Department of Surgery, Moffitt Cancer Center, Tampa, FL, USA.

Jennifer Tseng (J)

Department of Surgery, City of Hope, Irvine, CA, USA.

Jennifer Son (J)

Department of Surgery, MedStar Georgetown University, Washington, DC, USA.

Roshni Rao (R)

Department of Surgery, Columbia University Medical Center, New York, NY, USA.

Candice Sauder (C)

Department of Surgery, UC Davis Health Comprehensive Cancer Center, Sacramento, CA, USA.

Arpana Naik (A)

Department of Surgery, Oregon Health and Science University, Portland, OR, USA.

Marissa Howard-McNatt (M)

Department of Surgery, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Rachael Lancaster (R)

Division of Surgical Oncology, The University of Alabama at Birmingham Medical Center, Birmingham, AL, USA.

Peter Norwood (P)

Quantum Leap Healthcare Collaborative, San Francisco, CA, USA.

Laura J Esserman (LJ)

Department of Surgery, University of California San Francisco, San Francisco, CA, USA.

Rita A Mukhtar (RA)

Department of Surgery, University of California San Francisco, San Francisco, CA, USA. rita.mukhtar@ucsf.edu.
UCSF Breast Care Center, San Francisco, CA, USA. rita.mukhtar@ucsf.edu.

Classifications MeSH