A Multicenter Training and Interrater Reliability Study of the BASED Score for Infantile Epileptic Spasms Syndrome.

Journal

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society
ISSN: 1537-1603
Titre abrégé: J Clin Neurophysiol
Pays: United States
ID NLM: 8506708

Informations de publication

Date de publication:
11 Jul 2024
Historique:
medline: 12 7 2024
pubmed: 12 7 2024
entrez: 12 7 2024
Statut: aheadofprint

Résumé

The best possible outcomes in infantile epileptic spasms syndrome require electroclinical remission; however, determining electrographic remission is not straightforward. Although the determination of hypsarrhythmia has inadequate interrater reliability (IRR), the Burden of AmplitudeS and Epileptiform Discharges (BASED) score has shown promise for the reliable interictal assessment of infantile epileptic spasms syndrome. Our aim was to develop a BASED training program and assess the IRR among learners. We hypothesized moderate or better IRR for the final BASED score and the presence or absence of epileptic encephalopathy (+/-EE). Using a web-based application, 31 learners assessed 12 unmarked EEGs (length 1-6 hours) from children with infantile epileptic spasms syndrome. For all readers, the IRR was good for the final BASED score (intraclass correlation coefficient 0.86) and +/-EE (Marginal Multirater Kappa 0.63). For all readers, the IRR was fair to good for all individual BASED score elements. These findings support the use of our training program to quickly learn the BASED scoring method. The BASED score may be a valuable clinical and research tool. Given that the IRR for the determination of epileptic encephalopathy is not perfect, clinical acumen remains paramount. Additional experience with the BASED scoring technique among learners and advances in collaborative EEG evaluation platforms may improve IRR.

Identifiants

DOI: 10.1097/WNP.0000000000001101 PMID: 38995949
pubmed: 38995949
doi: 10.1097/WNP.0000000000001101
pii: 00004691-990000000-00161
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Pediatric Epilepsy Research Foundation, Children’s Hospital of Orange County Chief Scientific Officer Award, Children’s Hospital of Orange County Neuroscience Institute
ID : 88-06042021, 2021

Informations de copyright

Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Clinical Neurophysiology Society.

Déclaration de conflit d'intérêts

The authors have no funding or conflicts of interest to disclose.

Références

Shields WD. Infantile spasms: little seizures, BIG consequences. Epilepsy Curr 2006;6:63–69.
O'Callaghan FJK, Edwards SW, Alber FD, et al. Vigabatrin with hormonal treatment versus hormonal treatment alone (ICISS) for infantile spasms: 18-month outcomes of an open-label, randomised controlled trial. Lancet Child Adolesc Health 2018;2:715–725.
Hussain SA, Kwong G, Millichap JJ, et al. Hypsarrhythmia assessment exhibits poor interrater reliability: a threat to clinical trial validity. Epilepsia 2015;56:77–81.
Mytinger JR, Hussain SA, Islam MP, et al. Improving the inter-rater agreement of hypsarrhythmia using a simplified EEG grading scale for children with infantile spasms. Epilepsy Res 2015;116093–98.
Mytinger JR. Definitions and diagnostic criteria for infantile spasms and west syndrome - historical perspectives and practical considerations. Semin Pediatr Neurol 2021;38:100893.
Mytinger JR, Vidaurre J, Moore-Clingenpeel M, Stanek JR, Albert DVF. A reliable interictal EEG grading scale for children with infantile spasms – the 2021 BASED score. Epilepsy Res 2021;173:106631.
Koo TK, Li MY. A guideline of selecting and reporting intraclass correlation coefficients for reliability research. J Chiropr Med 2016;15:155–163.
Randolph J. Free-marginal multirater kappa: an alternative to Fleiss' fixed-marginal multirater kappa. Joensuu, Finland, 2005.
Fleiss J. Statistical methods for rates and proportions. Hoboken, NJ: Wiley, 1981.
Jing J, Herlopian A, Karakis I, et al. Interrater reliability of experts in identifying interictal epileptiform discharges in electroencephalograms. JAMA Neurol 2020;77:49–57.

Auteurs

John R Mytinger (JR)

Department of Pediatrics, Division of Pediatric Neurology, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, U.S.A.

Dara V F Albert (DVF)

Department of Pediatrics, Division of Pediatric Neurology, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, U.S.A.

Shawn C Aylward (SC)

Department of Pediatrics, Division of Pediatric Neurology, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, U.S.A.

Christopher W Beatty (CW)

Department of Pediatrics, Division of Pediatric Neurology, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, U.S.A.

Sonam Bhalla (S)

Division of Neurology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, U.S.A.
Division of Pediatric Neurology, Children's Healthcare of Atlanta, Atlanta, Georgia, U.S.A.

Sonal Bhatia (S)

Department of Pediatrics, Division of Pediatric Neurology, Medical University of South Carolina and Shawn Jenkins Children's Hospital, Charleston, South Carolina, U.S.A.

Guy N Brock (GN)

Department of Biomedical Informatics, College of Medicine.
Center for Biostatistics, Wexner Medical Center, Biostatistics Resource at NCH (BRANCH), Nationwide Children's Hospital and The Ohio State University, Columbus, OH, U.S.A.

Micheal A Ciliberto (MA)

Stead Family Department of Pediatrics, University of Iowa, Iowa City, Iowa, U.S.A.

Purva R Choudhari (PR)

Department of Pediatrics, Division of Pediatric Neurology, University of Texas Southwestern, Dallas, Texas, U.S.A.

Daniel J Clark (DJ)

Department of Pediatrics, Division of Pediatric Neurology, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, U.S.A.

Jennifer Madan Cohen (JM)

Department of Neurology, Connecticut Children's Hospital, University of Connecticut, Hartford, Connecticut, U.S.A.

Theresa M Czech (TM)

Stead Family Department of Pediatrics, University of Iowa, Iowa City, Iowa, U.S.A.

Megan M Fredwall (MM)

Department of Pediatrics, Division of Pediatric Neurology, Nationwide Children's Hospital, Columbus, Ohio, U.S.A.

Ernesto Gonzalez-Giraldo (E)

Department of Neurology, Division of Epilepsy, University of California, San Francisco, San Francisco, California, U.S.A.

Chellamani Harini (C)

Department of Neurology, Division of Epilepsy, Harvard University, Boston, Massachusetts, U.S.A.

Senyene E Hunter (SE)

Department of Neurology, Division of Child Neurology, University of North Carolina Hospitals, Chapel Hill, North Carolina, U.S.A.

Amanda G Sandoval Karamian (AG)

Division of Neurology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, U.S.A.

Akshat Katyayan (A)

Department of Pediatric Neurology and Developmental Neuroscience, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, U.S.A.

Isaac Kistler (I)

Center for Biostatistics, The Ohio State University Wexner Medical Center, Columbus, Ohio, U.S.A.
Biostatistics Resource at Nationwide Children's Hospital, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, U.S.A.

Neil Kulkarni (N)

Department of Pediatrics, Division of Pediatric Neurology, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, U.S.A.

Virginia B Liu (VB)

Division of Neurology, Orange California & Department of Pediatrics, Children's Hospital of Orange County, UC Irvine, Orange, California, U.S.A.

Corinne McCabe (C)

Department of Pediatrics, Division of Pediatric Neurology, Nationwide Children's Hospital, Columbus, Ohio, U.S.A.

Thomas Murray (T)

Department of Pediatrics, Division of Pediatric Neurology, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, U.S.A.

Kerri Neville (K)

Department of Pediatrics, Division of Pediatric Neurology, University of Michigan, Ann Arbor, Michigan, U.S.A.

Shital H Patel (SH)

Department of Pediatrics, Division of Pediatric Neurology, Duke University Medical Center, Durham, North Carolina, U.S.A.

Spriha Pavuluri (S)

Children's Hospital and Medical Center, Omaha, Nebraska, U.S.A.

Donald J Phillips (DJ)

Division of Neurology, Orange California & Department of Pediatrics, Children's Hospital of Orange County, UC Irvine, Orange, California, U.S.A.

Debopam Samanta (D)

Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, U.S.A.

Deepa Sirsi (D)

Department of Pediatrics, Division of Pediatric Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, U.S.A.

Emily M Spelbrink (EM)

Department of Neurology, Division of Child Neurology, Stanford Children's Hospital, Stanford University, Palo Alto, California, U.S.A.

Carl E Stafstrom (CE)

Division of Pediatric Neurology, Departments of Neurology and Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.

Maija Steenari (M)

Division of Neurology, Orange California & Department of Pediatrics, Children's Hospital of Orange County, UC Irvine, Orange, California, U.S.A.

Danielle S Takacs (DS)

Department of Pediatric Neurology and Developmental Neuroscience, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, U.S.A.

Tyler Terrill (T)

Department of Pediatrics, Division of Pediatric Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, U.S.A.

Linh Tran (L)

Comprehensive Epilepsy Program, Jane and John Justin Neuroscience Center, Cook Children's Medical Center, Fort Worth, Texas, U.S.A.

Jorge Vidaurre (J)

Department of Pediatrics, Division of Pediatric Neurology, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, U.S.A.

Daniel W Shrey (DW)

Division of Neurology, Orange California & Department of Pediatrics, Children's Hospital of Orange County, UC Irvine, Orange, California, U.S.A.

Classifications MeSH