Comparison of primary and metastatic FH-deficient renal cell carcinomas documents morphologic divergence and potential diagnostic pitfall with peritoneal mesothelioma.
cancer biomarkers
diagnostic pitfall
differential diagnosis
fumarate hydratase
intratumoral heterogeneity
renal cell carcinoma
Journal
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
ISSN: 1530-0285
Titre abrégé: Mod Pathol
Pays: United States
ID NLM: 8806605
Informations de publication
Date de publication:
10 Jul 2024
10 Jul 2024
Historique:
received:
23
02
2024
revised:
05
06
2024
accepted:
01
07
2024
medline:
13
7
2024
pubmed:
13
7
2024
entrez:
12
7
2024
Statut:
aheadofprint
Résumé
Fumarate hydratase (FH)-deficient renal cell carcinomas are rare neoplasms characterized by a wide morphological heterogeneity and pathogenetic mutations in the FH gene. They often show aggressive behavior with rapid diffusion to distant organs, so novel therapeutic scenarios have been explored, including EGFR inhibitors and PD-L1 expression for targeted immunotherapy. Herein, we investigated a series of eleven primary FH-deficient renal cell carcinomas and seven distant metastases to evaluate tumor heterogeneity even in metastatic sites and estimate the specific spread rates to various organs. Furthermore, the tumors were tested for immunohistochemical PD-L1 expression and EGFR mutations. Most metastatic cases involved the abdominal lymph nodes (4/7, 57%), followed by the peritoneum (3/7, 42%), the liver (2/7, 29%), and the lungs (1/7, 14%). Six metastatic localizations were histologically documented, revealing morphological heterogeneous architecture often differing from the corresponding primary renal tumor. Peritoneal involvement morphologically resembled a benign reactive mesothelial process or primary peritoneal mesothelioma, thus advocating to perform an accurate immunohistochemical panel, including PAX 8 and FH, to reach the proper diagnosis. A pure low-grade SDH-looking primary FH-deficient renal cell carcinoma was also recorded. As for therapy, significant PD-L1 labeling was found in 60% of primary renal tumors, while none of them carried pathogenetic EGFR mutations. Our data show that FH-deficient renal cell carcinoma may be morphologically heterogeneous in metastases as well, which involve the lymph nodes, the liver, and the peritoneum more frequently than other renal tumors. Due to the high frequency of this latter (42%), pathologists should always be concerned about ruling out mesothelial-derived mimickers, and the occurrence of rarer primary low-grade-looking types. Finally, contrary to EGFR mutations, PD-L1 expression could be a possible predictive biomarker for the therapy of these tumors.
Identifiants
pubmed: 38996839
pii: S0893-3952(24)00141-8
doi: 10.1016/j.modpat.2024.100561
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
100561Informations de copyright
Copyright © 2024. Published by Elsevier Inc.