Practical synthesis of chenodeoxycholic acid from phocaecholic acid.

23-Hydroxyl group Chenodeoxycholic acid Phocaecholic acid Steroid

Journal

Steroids
ISSN: 1878-5867
Titre abrégé: Steroids
Pays: United States
ID NLM: 0404536

Informations de publication

Date de publication:
10 Jul 2024
Historique:
received: 25 04 2024
revised: 02 07 2024
accepted: 08 07 2024
medline: 13 7 2024
pubmed: 13 7 2024
entrez: 12 7 2024
Statut: aheadofprint

Résumé

In this study, we developed an effective method for the large-scale synthesis of chenodeoxycholic acid (CDCA) from phocaecholic acid (PhCA). A high total yield of up to 72 % was obtained via five steps including methyl esterification, Ts-protection, bromination, reduction, and hydrolysis. The structures of the intermediates were confirmed by

Identifiants

DOI: 10.1016/j.steroids.2024.109470 PMID: 38997080
pubmed: 38997080
pii: S0039-128X(24)00108-9
doi: 10.1016/j.steroids.2024.109470
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

109470

Informations de copyright

Copyright © 2024. Published by Elsevier Inc.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Zengliang He (Z)

Department of Chemistry, Xihua University, Chengdu 610039, China; Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China; University of Chinese Academy of Sciences, Beijing 100049, China.

Nengde Liang (N)

Department of Chemistry, Xihua University, Chengdu 610039, China.

Sheng Zou (S)

Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China.

Fang Yu (F)

Department of Chemistry, Xihua University, Chengdu 610039, China.

Yi Zeng (Y)

Department of Chemistry, Xihua University, Chengdu 610039, China. Electronic address: zengy@mail.edu.cn.

Xingjun Chen (X)

Department of Chemistry, Xihua University, Chengdu 610039, China.

Yuanhua Wang (Y)

College of Chemistry, Sichuan University, Chengdu 610041, China. Electronic address: yhwang@scu.edu.cn.

Li Zhou (L)

Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China. Electronic address: zhouli@cib.ac.cn.

Qiwei Wang (Q)

Department of Chemistry, Xihua University, Chengdu 610039, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: wqw@cioc.ac.cn.

Classifications MeSH