Effect of time since vasectomy on live birth rate of TESE‒ICSI egg donation cycles and male-related prognostic factors.
cumulative live birth rates
diabetes
oocyte donation
testicular sperm extraction
vasectomy
Journal
Andrology
ISSN: 2047-2927
Titre abrégé: Andrology
Pays: England
ID NLM: 101585129
Informations de publication
Date de publication:
12 Jul 2024
12 Jul 2024
Historique:
revised:
19
06
2024
received:
31
10
2023
accepted:
03
07
2024
medline:
13
7
2024
pubmed:
13
7
2024
entrez:
12
7
2024
Statut:
aheadofprint
Résumé
Vasectomy is a widely used method of contraception. However, some men may have the desire to become biological fathers again after a period. To explore the effect of time since vasectomy and different male comorbidities on live birth rates from intracytoplasmic sperm injection cycles using donated oocytes by using testicular spermatozoa obtained by testicular sperm extraction. This was a retrospective study of 123 couples who underwent a testicular sperm extraction‒intracytoplasmic sperm injection cycle after vasectomy using donated oocytes. Subjects were divided into groups according to time since vasectomy and the male risk factor evaluated. The main outcomes measured were live birth rate per embryo transfer, per oocyte donation cycle, and per couple. We assessed the cumulative live birth rate according to the time since vasectomy and considered male comorbidities: body mass index, hypertension, diabetes mellitus, dyslipidemia, and smoking. The overall live birth rate per couple was 59.3% (50.6-68.0). Considering the number of embryo transfer and oocyte donation cycle, the live birth rates were 34.1% (27.8-40.4) and 44.5% (36.9-52.1), respectively. The live birth rate according to time since vasectomy was not statistically different between groups. Consequently, the cumulative live birth rate was similar between the different interval times when considering one to eight embryo transfers (p = 0.74). No statistical differences in live birth rate and cumulative live birth rate were found between groups clustered according to male body mass index, smoking, hypertension, and dyslipidemia. However, diabetic male patients had a significantly lower rate of live birth rate per couple (22.2% [4.94-49.4]) than non-diabetic patients did (62.7% [53.7-71.8]) (p = 0.03), but not in their cumulative live birth rate. The time since vasectomy seems to have no detrimental effects on the live birth rate and cumulative live birth rate in testicular sperm extraction‒intracytoplasmic sperm injection cycles with donated oocytes. Male diabetes negatively affects the overall live birth rate per couple, but not the cumulative live birth rate. These results could be useful for multidisciplinary patient-tailored counseling, regarding the chance of having a pregnancy and facilitating the decision-making process of the fertility specialists.
Sections du résumé
BACKGROUND
BACKGROUND
Vasectomy is a widely used method of contraception. However, some men may have the desire to become biological fathers again after a period.
OBJECTIVE
OBJECTIVE
To explore the effect of time since vasectomy and different male comorbidities on live birth rates from intracytoplasmic sperm injection cycles using donated oocytes by using testicular spermatozoa obtained by testicular sperm extraction.
MATERIALS AND METHODS
METHODS
This was a retrospective study of 123 couples who underwent a testicular sperm extraction‒intracytoplasmic sperm injection cycle after vasectomy using donated oocytes. Subjects were divided into groups according to time since vasectomy and the male risk factor evaluated. The main outcomes measured were live birth rate per embryo transfer, per oocyte donation cycle, and per couple. We assessed the cumulative live birth rate according to the time since vasectomy and considered male comorbidities: body mass index, hypertension, diabetes mellitus, dyslipidemia, and smoking.
RESULTS
RESULTS
The overall live birth rate per couple was 59.3% (50.6-68.0). Considering the number of embryo transfer and oocyte donation cycle, the live birth rates were 34.1% (27.8-40.4) and 44.5% (36.9-52.1), respectively. The live birth rate according to time since vasectomy was not statistically different between groups. Consequently, the cumulative live birth rate was similar between the different interval times when considering one to eight embryo transfers (p = 0.74). No statistical differences in live birth rate and cumulative live birth rate were found between groups clustered according to male body mass index, smoking, hypertension, and dyslipidemia. However, diabetic male patients had a significantly lower rate of live birth rate per couple (22.2% [4.94-49.4]) than non-diabetic patients did (62.7% [53.7-71.8]) (p = 0.03), but not in their cumulative live birth rate.
CONCLUSIONS
CONCLUSIONS
The time since vasectomy seems to have no detrimental effects on the live birth rate and cumulative live birth rate in testicular sperm extraction‒intracytoplasmic sperm injection cycles with donated oocytes. Male diabetes negatively affects the overall live birth rate per couple, but not the cumulative live birth rate. These results could be useful for multidisciplinary patient-tailored counseling, regarding the chance of having a pregnancy and facilitating the decision-making process of the fertility specialists.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024 American Society of Andrology and European Academy of Andrology.
Références
Ostrowski KA, Holt SK, Haynes B, Davies BJ, Fuchs EF, Walsh TJ. Evaluation of vasectomy trends in the United States. Urology. 2018;118:76‐79. doi:10.1016/j.urology.2018.03.016
Sharma V, Le BV, Sheth KR, et al. Vasectomy demographics and postvasectomy desire for future children: results from a contemporary national survey. Fertil Steril. 2013;99(7):1880‐1885. doi:10.1016/j.fertnstert.2013.02.032
Namekawa T, Imamoto T, Kato M, Komiya A, Ichikawa T. Vasovasostomy and vasoepididymostomy: review of the procedures, outcomes, and predictors of patency and pregnancy over the last decade. Reprod Med Biol. 2018;17(4):343‐355. doi:10.1002/rmb2.12207
Fuchs EF, Burt RA. Vasectomy reversal performed 15 years or more after vasectomy: correlation of pregnancy outcome with partner age and with pregnancy results of in vitro fertilization with intracytoplasmic sperm injection. Fertil Steril. 2002;77(3):516‐519.
Agarwal A, Gupta S, Sharma RK, et al. Post‐vasectomy semen analysis: optimizing laboratory procedures and test interpretation through a clinical audit and global survey of practices. World J Men's Health. 2022;40(3):425‐441. doi:10.5534/wjmh.210191
Bryk DJ, Murthy PB, DeWitt‐Foy M, et al. Childless men at the time of vasectomy are unlikely to seek fertility restoration. Urology. 2020;136:142‐145. doi:10.1016/j.urology.2019.12.003
Eisenberg ML, Lipshultz LI. Estimating the number of vasectomies performed annually in the united states: data from the national survey of family growth. J Urol. 2010;184(5):2068‐2072. doi:10.1016/j.juro.2010.06.117
Schwingl PJ, Guess HA. Safety and effectiveness of vasectomy. Fertil Steril. 2000;73(5):923‐936.
Cheng PJ, Kim J, Craig JR, et al. “The back‐up vasectomy reversal.” Simultaneous sperm retrieval and vasectomy reversal in the couple with advanced maternal age: a cost‐effectiveness analysis. Urology. 2021;153:175‐180. doi:10.1016/j.urology.2021.03.021
The Practice Committee of the American Society for Reproductive Medicine. The management of obstructive azoospermia: a committee opinion. Fertil Steril. 2019;111(5):873‐880. doi:10.1016/j.fertnstert.2019.02.013
Practice Committee of the American Society for Reproductive Medicine in collaboration with the Society for Male Reproduction and Urology. Evaluation of the azoospermic male: a committee opinion. Fertil Steril. 2018;109(5):777‐782. doi:10.1016/j.fertnstert.2018.01.043
Desai N, AbdelHafez F, Sabanegh E, Goldfarb J. Paternal effect on genomic activation, clinical pregnancy and live birth rate after ICSI with cryopreserved epididymal versus testicular spermatozoa. Reprod Biol Endocrinol. 2009;7:1‐7. doi:10.1186/1477‐7827‐7‐142
Esteves SC, Prudencio C, Seol B, Verza S, Knoedler C, Agarwal A. Comparison of sperm retrieval and reproductive outcome in azoospermic men with testicular failure and obstructive azoospermia treated for infertility. Asian J Androl. 2014;16(4):602‐606. doi:10.4103/1008‐682X.126015
Esteves SC, Agarwal A. Reproductive outcomes, including neonatal data, following sperm injection in men with obstructive and nonobstructive azoospermia: case series and systematic review. Clinics. 2013;68(1 suppl):141‐149. doi:10.6061/clinics/2013(Sup01)16
Habermann H, Seo R, Cieslak J, Niederberger C, Prins GS, Ross L. In vitro fertilization outcomes after intracytoplasmic sperm injection with fresh or frozen‐thawed testicular spermatozoa. Fertil Steril. 2000;73(5):955‐960. doi:10.1016/S0015‐0282(00)00416‐7
Schwarzer JU, Fiedler K, Hertwig IV, et al. Male factors determining the outcome of intracytoplasmic sperm injection with epididymal and testicular spermatozoa. Andrologia. 2003;35(4):220‐226. doi:10.1046/j.1439‐0272.2003.00563.x
McVicar CM, O'Neill DA, McClure N, Clements B, McCullough S, Lewis SEM. Effects of vasectomy on spermatogenesis and fertility outcome after testicular sperm extraction combined with ICSI. Hum Reprod. 2005;20(10):2795‐2800. doi:10.1093/humrep/dei138
Raleigh D, O'Donnell L, Southwick GJ, De Kretser DM, McLachlan RI. Stereological analysis of the human testis after vasectomy indicates impairment of spermatogenic efficiency with increasing obstructive interval. Fertil Steril. 2004;81(6):1595‐1603. doi:10.1016/j.fertnstert.2003.10.046
Abdelmassih V, Balmaceda JP, Tesarik J, Abdelmassih R, Nagy ZP. Relationship between time period after vasectomy and the reproductive capacity of sperm obtained by epididymal aspiration. Hum Reprod. 2002;17(3):736‐740. doi:10.1093/humrep/17.3.736
Borges E, de Braga DPAF, Iaconelli A, Setti AS. The obstructive interval predicts pregnancy rates in post‐vasectomy patients undergoing ICSI with surgical sperm retrieval. Reprod Biomed Online. 2019;39(1):134‐140. doi:10.1016/j.rbmo.2019.02.002
Wood S, Vang E, Troup S, Kingsland CR, Lewis‐Jones DI. Surgical sperm retrieval after previous vasectomy and failed reversal: clinical implications for in vitro fertilization. BJU Int. 2002;90(3):277‐281. doi:10.1046/j.1464‐410X.2002.02843.x
Borges E, Rossi‐Ferragut LM, Pasqualotto FF, Rocha CC, Iaconelli A. Different intervals between vasectomy and sperm retrieval interfere in the reproductive capacity from vasectomized men. J Assist Reprod Genet. 2003;20(1):33‐37. doi:10.1023/A:1021210805867
Hervás I, Valls L, Rivera‐Egea R, et al. TESE‒ICSI outcomes per couple in vasectomized males are negatively affected by time since the intervention, but not other comorbidities. Reprod Biomed Online. 2021;00(0):1‐10. doi:10.1016/j.rbmo.2021.05.013
Bromage SJ, Douglas J, Falconer DA, Lieberman BA, Payne SR. Factors affecting successful outcome from ICSI in men following previous vasectomy. World J Urol. 2007;25(5):519‐524. doi:10.1007/s00345‐007‐0182‐7
Vieira M, Glina FPA, Mizrahi FE, Perin PM, Mierzwa TC, Glina S. Is time since vasectomy more important as prognostic factor for pregnancy and live birth than female and laboratory variables when treating vasectomised man using ICSI? Andrologia. 2020;52(4):1‐6. doi:10.1111/and.13534
Penzias A, Bendikson K, Butts S, et al. Smoking and infertility: a committee opinion. Fertil Steril. 2018;110(4):611‐618. doi:10.1016/j.fertnstert.2018.06.016
The Practice Committees of the American Society for Reproductive Medicine. Obesity and reproduction: a committee opinion. Fertil Steril. 2015;104(5):1116‐1126. doi:10.1016/j.fertnstert.2015.08.018
Yafi FA, Zini A. Percutaneous epididymal sperm aspiration for men with obstructive azoospermia: predictors of successful sperm retrieval. Urology. 2013;82(2):341‐344. doi:10.1016/j.urology.2013.04.014
Pellicer A, Simo C, Meseguer M, Garrido N, Remohõ J, Martõ JM. Testicular sperm extraction (TESE) and ICSI in patients with permanent azoospermia after chemotherapy. Hum Reprod. 2003;18(6):1281‐1285. doi:10.1093/humrep/deg281
Meseguer M, Garrido N, Remohí J, Pellicer A, Gil‐Salom M. Testicular sperm extraction (TESE) and intracytoplasmic sperm injection (ICSI) in hypogonadotropic hypogonadism with persistent azoospermia after hormonal therapy. J Assist Reprod Genet. 2004;21(3):91‐94. doi:10.1023/B:JARG.0000027021.66435.02
Meseguer M, Santiso R, Garrido N, Gil‐Salom M, Remohí J, Fernandez JL. Sperm DNA fragmentation levels in testicular sperm samples from azoospermic males as assessed by the sperm chromatin dispersion (SCD) test. Fertil Steril. 2009;92(5):1638‐1645. doi:10.1016/j.fertnstert.2008.08.106
Garrido N, Zuzuarregui JL, Meseguer M, Simón C, Remohí J, Pellicer A. Sperm and oocyte donor selection and management: experience of a 10 year follow‐up of more than 2100 candidates. Hum Reprod. 2002;17(12):3142‐3148. doi:10.1093/humrep/17.12.3142
Garcia‐velasco JA, Domingo J, Cobo A, Ph D, Martínez M. Five years’ experience using oocyte vitri fi cation to preserve fertility for medical and nonmedical indications. Fertil Steril. 2013;99(7):1994‐1999. doi:10.1016/j.fertnstert.2013.02.004
Cobo A, Garrido N, Pellicer A, Remohí J. Six years’ experience in ovum donation using vitrified oocytes: report of cumulative outcomes, impact of storage time, and development of a predictive model for oocyte survival rate. Fertil Steril. 2015;104(6):1426‐1434. doi:10.1016/j.fertnstert.2015.08.020
Cobo A, García‐Velasco JA, Coello A, Domingo J, Pellicer A, Remohí J. Oocyte vitrification as an efficient option for elective fertility preservation. Fertil Steril. 2016;105(3):755‐764.e8 doi:10.1016/j.fertnstert.2015.11.027
Esbert M, Pacheco A, Soares SR, et al. High sperm DNA fragmentation delays human embryo kinetics when oocytes from young and healthy donors are microinjected. Andrology. 2018;6(5):697‐706. doi:10.1111/andr.12551
ASEBIR. Cuadernos de embriología clínica. Asociación para el Estudio de la Biología de la Reproducción. 3rd ed. 2015.
Cobo A, Kuwayama M, Pérez S, Ruiz A, Pellicer A, Remohí J. Comparison of concomitant outcome achieved with fresh and cryopreserved donor oocytes vitrified by the Cryotop method. Fertil Steril. 2008;89(6):1657‐1664. doi:10.1016/j.fertnstert.2007.05.050
Cobo A, De Los Santos MJ, Castellò D, Gámiz P, Campos P, Remohí J. Outcomes of vitrified early cleavage‐stage and blastocyst‐stage embryos in a cryopreservation program: evaluation of 3,150 warming cycles. Fertil Steril. 2012;98(5):1138‐1146.e1. doi:10.1016/j.fertnstert.2012.07.1107
Soares SR, Troncoso C, Bosch E, et al. Age and uterine receptiveness: predicting the outcome of oocyte donation cycles. J Clin Endocrinol Metab. 2005;90(7):4399‐4404. doi:10.1210/jc.2004‐2252
Valerie U, De Brucker S, De Brucker M, et al. Pregnancy after vasectomy: surgical reversal or assisted reproduction? Hum Reprod. 2018;33(7):1218‐1227. doi:10.1093/humrep/dey101
Nicopoullos JDM, Gilling‐Smith C, Almeida PA, Ramsay JWA. Effect of time since vasectomy and maternal age on intracytoplasmic sperm injection success in men with obstructive azoospermia after vasectomy. Fertil Steril. 2004;82(2):367‐373. doi:10.1016/j.fertnstert.2003.12.037
Sukcharoen N, Sithipravej T, Promviengchai S, Chinpilas V, Boonkasemsanti W. No differences in outcome of surgical sperm retrieval withintracytoplasmic sperm injection at different intervals after vasectomy. Fertil Steril. 2000;74(1):174‐175. doi:10.1016/S0015‐0282(00)00579‐3
Cozzolino M, García‐Velasco JA, Meseguer M, Pellicer A, Bellver J. Female obesity increases the risk of miscarriage of euploid embryos. Fertil Steril. 2021;115(6):1495‐1502. doi:10.1016/j.fertnstert.2020.09.139
Silvestris E, de Pergola G, Rosania R, Loverro G. Obesity as disruptor of the female fertility. Reprod Biol Endocrinol. 2018;16(1):22. doi:10.1186/s12958‐018‐0336‐z
Colli LG, Belardin LB, Echem C, et al. Systemic arterial hypertension leads to decreased semen quality and alterations in the testicular microcirculation in rats. Sci Rep. 2019;9(1):1‐12. doi:10.1038/s41598‐019‐47157‐w
Eisenberg ML, Li S, Behr B, Pera RR, Cullen MR. Relationship between semen production and medical comorbidity. Fertil Steril. 2015;103(1):66‐71. doi:10.1016/j.fertnstert.2014.10.017
Ding GL, Liu Y, Liu ME, et al. The effects of diabetes on male fertility and epigenetic regulation during spermatogenesis. Asian J Androl. 2015;17(6):948‐953. doi:10.4103/1008‐682X.150844
Condorelli RA, La Vignera S, Mongioì LM, Alamo A, Calogero AE. Diabetes mellitus and infertility: different pathophysiological effects in type 1 and type 2 on sperm function. Front Endocrinol (Lausanne). 2018;9:268. doi:10.3389/fendo.2018.00268
Practice Committee of the American Society for Reproductive Medicine. Smoking and infertility: a committee opinion. Fertil Steril. 2018;110(4):611‐618. doi:10.1016/j.fertnstert.2018.06.016
de Jong AME, Menkveld R, Lens JW, Nienhuis SE, Rhemrev JPT. Effect of alcohol intake and cigarette smoking on sperm parameters and pregnancy. Andrologia. 2014;46(2):112‐117. doi:10.1111/and.12054
Gunes S, Metin Mahmutoglu A, Arslan MA, Henkel R. Smoking‐induced genetic and epigenetic alterations in infertile men. Andrologia. 2018;50(9):e13124. doi:10.1111/and.13124
Van Dongen J, Tekle FB, Van Roijen JH. Pregnancy rate after vasectomy reversal in a contemporary series: influence of smoking, semen quality and post‐surgical use of assisted reproductive techniques. BJU Int. 2012;110(4):562‐567. doi:10.1111/j.1464‐410X.2011.10781.x
Patel AP, Smith RP. Vasectomy reversal: a clinical update. Asian J Androl. 2016;18(3):365‐371. doi:10.4103/1008‐682X.175091
Coward RM, Mills JN. A step‐by‐step guide to office‐based sperm retrieval for obstructive azoospermia. Transl Androl Urol. 2017;6(4):730‐744. doi:10.21037/tau.2017.07.15
Esteves SC, Miyaoka R, Agarwal A. Sperm retrieval techniques for assisted reproduction. Int Braz J Urol. 2011;37(5):570‐583. doi:10.1590/S1677‐55382011000500002
Van Peperstraten AM, Proctor ML, Johnson NP, Philipson G. Techniques for surgical retrieval of sperm prior to intracytoplasmic sperm injection (ICSI) for azoospermia. Cochrane Database Syst Rev. 2008(2):CD002807. doi:10.1002/14651858.CD002807.pub3
Verza S, Esteves SC. Associated with lower fertilization rates after intracytoplasmic sperm injection. Int Braz J Urol. 2008;34(1):49‐56.
Hammoud I, Bailly M, Bergere M, et al. Testicular spermatozoa are of better quality than epididymal spermatozoa in patients with obstructive azoospermia. Urology. 2017;103:106‐111. doi:10.1016/j.urology.2016.11.019
Bernie AM, Ramasamy R, Stember DS, Stahl PJ. Microsurgical epididymal sperm aspiration: indications, techniques and outcomes. Asian J Androl. 2013;15(1):40‐43. doi:10.1038/aja.2012.114
Vander Borght M, Wyns C. Fertility and infertility: definition and epidemiology. Clin Biochem. 2018;62:2‐10. doi:10.1016/j.clinbiochem.2018.03.012
Mahesan AM, Sadek S, Moussavi V, et al. Clinical outcomes following ICSI cycles using surgically recovered sperm and the impact of maternal age: 2004–2015 SART CORS registry. J Assist Reprod Genet. 2018;35(7):1239‐1246. doi:10.1007/s10815‐018‐1234‐1