Genetic and multi-omic resources for Alzheimer disease and related dementia from the Knight Alzheimer Disease Research Center.

Alzheimer Disease / genetics Humans Genomics Biomarkers Dementia / genetics Proteomics Multiomics

Journal

Scientific data
ISSN: 2052-4463
Titre abrégé: Sci Data
Pays: England
ID NLM: 101640192

Informations de publication

Date de publication:
12 Jul 2024
Historique:
received: 24 01 2024
accepted: 06 06 2024
medline: 13 7 2024
pubmed: 13 7 2024
entrez: 12 7 2024
Statut: epublish

Résumé

The Knight-Alzheimer Disease Research Center (Knight-ADRC) at Washington University in St. Louis has pioneered and led worldwide seminal studies that have expanded our clinical, social, pathological, and molecular understanding of Alzheimer Disease. Over more than 40 years, research volunteers have been recruited to participate in cognitive, neuropsychologic, imaging, fluid biomarkers, genomic and multi-omic studies. Tissue and longitudinal data collected to foster, facilitate, and support research on dementia and aging. The Genetics and high throughput -omics core (GHTO) have collected of more than 26,000 biological samples from 6,625 Knight-ADRC participants. Samples available include longitudinal DNA, RNA, non-fasted plasma, cerebrospinal fluid pellets, and peripheral blood mononuclear cells. The GHTO has performed deep molecular profiling (genomic, transcriptomic, epigenomic, proteomic, and metabolomic) from large number of brain (n = 2,117), CSF (n = 2,012) and blood/plasma (n = 8,265) samples with the goal of identifying novel risk and protective variants, identify novel molecular biomarkers and causal and druggable targets. Overall, the resources available at GHTO support the increase of our understanding of Alzheimer Disease.

Identifiants

DOI: 10.1038/s41597-024-03485-9 PMID: 38997326
pubmed: 38997326
doi: 10.1038/s41597-024-03485-9
pii: 10.1038/s41597-024-03485-9
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article Dataset

Langues

eng

Sous-ensembles de citation

IM

Pagination

768

Subventions

Organisme : U.S. Department of Health & Human Services | NIH | Center for Scientific Review (NIH Center for Scientific Review)
ID : P30AG066444

Informations de copyright

© 2024. The Author(s).

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Auteurs

Maria Victoria Fernandez (MV)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Research Center and Memory Clinic, ACE Alzheimer Center, Barcelona, Spain.

Menghan Liu (M)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.

Aleksandra Beric (A)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.
ORCID: 0000-0002-9351-585X

Matt Johnson (M)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.

Arda Cetin (A)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.
ORCID: 0000-0003-4297-5984

Maulik Patel (M)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.

John Budde (J)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.
ORCID: 0000-0001-7778-7276

Pat Kohlfeld (P)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.
ORCID: 0009-0004-9206-8244

Kristy Bergmann (K)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.

Joseph Lowery (J)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.

Allison Flynn (A)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.

William Brock (W)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.

Brenda Sanchez Montejo (B)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.

Jen Gentsch (J)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.

Nicholas Sykora (N)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.

Joanne Norton (J)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.

Jen Gentsch (J)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.

Olga Valdez (O)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.

Priyanka Gorijala (P)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.

Jessie Sanford (J)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.

Yichen Sun (Y)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.

Ciyang Wang (C)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.

Dan Western (D)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.
ORCID: 0000-0003-3725-9553

Jigyasha Timsina (J)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.

Tassia Mangetti Goncalves (T)

Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.

Anh N Do (AN)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, 63110, USA.

Yun Ju Sung (YJ)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA.

Guoyan Zhao (G)

Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Pathology and Immunology Department, Washington University School of Medicine, St. Louis, MO, 63110, USA.
ORCID: 0000-0001-5615-6774

John C Morris (JC)

Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.

Krista Moulder (K)

Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.

David M Holtzman (DM)

Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA.
ORCID: 0000-0002-3400-0856

Randall J Bateman (RJ)

Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA.
Dominantly Inherited Alzheimer Disease Network (DIAN), St. Louis, USA.
ORCID: 0000-0002-7729-1702

Celeste Karch (C)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA.
Dominantly Inherited Alzheimer Disease Network (DIAN), St. Louis, USA.
ORCID: 0000-0002-6854-5547

Jason Hassenstab (J)

Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.

Chengjie Xiong (C)

Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
Dominantly Inherited Alzheimer Disease Network (DIAN), St. Louis, USA.

Suzanne E Schindler (SE)

Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
ORCID: 0000-0002-1680-1465

Joyce Joy Balls-Berry (JJ)

Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.

Tammie L S Benzinger (TLS)

Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
Dominantly Inherited Alzheimer Disease Network (DIAN), St. Louis, USA.
Radiology Department, Washington University School of Medicine, St. Louis, MO, 63110, USA.

Richard J Perrin (RJ)

Pathology and Immunology Department, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
Dominantly Inherited Alzheimer Disease Network (DIAN), St. Louis, USA.
ORCID: 0000-0002-3443-7716

Andrea Denny (A)

Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.

B Joy Snider (BJ)

Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA.

Susan L Stark (SL)

Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
Occupational Therapy, Neurology and Social Work, St. Louis, USA.

Laura Ibanez (L)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. ibanezl@wustl.edu.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA. ibanezl@wustl.edu.
Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA. ibanezl@wustl.edu.
Dominantly Inherited Alzheimer Disease Network (DIAN), St. Louis, USA. ibanezl@wustl.edu.

Carlos Cruchaga (C)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. cruchagac@wustl.edu.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, 63110, USA. cruchagac@wustl.edu.
Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA. cruchagac@wustl.edu.
Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA. cruchagac@wustl.edu.
Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA. cruchagac@wustl.edu.
Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA. cruchagac@wustl.edu.
Dominantly Inherited Alzheimer Disease Network (DIAN), St. Louis, USA. cruchagac@wustl.edu.
ORCID: 0000-0002-0276-2899

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Genetic and multi-omic resources for Alzheimer...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genetic and multi-omic resources for Alzheimer...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Genetic and multi-omic resources for Alzheimer...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Genetic and multi-omic resources for Alzheimer...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Genetic and multi-omic resources for Alzheimer...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › Genetic and multi-omic resources for Alzheimer...
questionsmedicales.fr › Sciences de l'information › Informatique › Biologie informatique › Multi-omique › Genetic and multi-omic resources for Alzheimer...