Rat Ductal Cell-Derived Differentiation into Islet-Like Cells.

Diabetes Differentiation methods Ductal cells Islet cell Rat pancreas

Journal

Methods in molecular biology (Clifton, N.J.)

ISSN: 1940-6029

Titre abrégé: Methods Mol Biol

Pays: United States

ID NLM: 9214969

Informations de publication

Date de publication:
13 Jul 2024

Historique:

medline: 13 7 2024

pubmed: 13 7 2024

entrez: 12 7 2024

Statut: aheadofprint

Résumé

Regenerative medicine investigates the conversion of pancreatic ductal cells into functional islet cells, offering innovative treatments for conditions such as diabetes. Ductal cells, primarily supporting the pancreas' exocrine functions, can differentiate into various cell types, including islet cells, under specific conditions, opening new avenues in research and therapy. The outlined protocol elaborates on the conversion process, covering ductal cell differentiation induction, and insulin-producing capacity assessment. The primary objective is to address the shortage of insulin-secreting cells for transplantation, thereby advancing diabetes treatment methodologies.

Identifiants

DOI: 10.1007/7651_2024_558 PMID: 38997537

pubmed: 38997537

doi: 10.1007/7651_2024_558

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Informations de copyright

Références

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