What to Measure in Aneurysmal Subarachnoid Haemorrhage Research-An International Delphi Survey.

Cerebral aneurysm Core outcome set Patient-important outcomes Subarachnoid hemorrhage

Journal

Translational stroke research
ISSN: 1868-601X
Titre abrégé: Transl Stroke Res
Pays: United States
ID NLM: 101517297

Informations de publication

Date de publication:
13 Jul 2024
Historique:
received: 07 05 2024
accepted: 17 06 2024
revised: 13 06 2024
medline: 13 7 2024
pubmed: 13 7 2024
entrez: 12 7 2024
Statut: aheadofprint

Résumé

Aneurysmal subarachnoid haemorrhage (aSAH) is a devastating condition with high mortality and morbidity. The outcome measures used in aSAH clinical research vary making it challenging to compare and combine different studies. Additionally, there may be a mismatch between the outcomes prioritized by patients, caregivers, and health care providers and those selected by researchers. We conducted an international, online, multiple round Delphi study to develop consensus on domains (where a domain is a health concept or aspect) prioritized by key stakeholders including those with lived experience of aSAH, health care providers, and researchers, funders, or industry professionals. One hundred seventy-five people participated in the survey, 59% of whom had lived experience of aSAH. Over three rounds, 32 domains reached the consensus threshold pre-defined as 70% of participants rating the domain as being critically important. During the fourth round, participants ranked the importance of each of these 32 domains. The top ten domains ranked highest to lowest were (1) Cognition and executive function, (2) Aneurysm obliteration, (3) Cerebral infarction, (4) Functional outcomes including ability to walk, (5) Delayed cerebral ischemia, (6) The overall quality of life as reported by the SAH survivor, (7) Changes to emotions or mood (including depression), (8) The basic activities of daily living, (9) Vasospasm, and (10) ICU complications. Our findings confirm that there is a mismatch between domains prioritized by stakeholders and outcomes used in clinical research. Our future work aims to address this mismatch through the development of a core outcome set in aSAH research.

Identifiants

DOI: 10.1007/s12975-024-01271-8 PMID: 38997598
pubmed: 38997598
doi: 10.1007/s12975-024-01271-8
pii: 10.1007/s12975-024-01271-8
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Investigateurs

Brenda Lucas (B)

Informations de copyright

© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Auteurs

Christopher R Andersen (CR)

Malcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, Sydney, Australia.
Critical Care Program, The George Institute for Global Health, University of New South Wales Sydney, Sydney, Australia.
Northern Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.

Justin Presseau (J)

Methodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.

Bev Shea (B)

Methodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.

Maria Luisa Marti (ML)

Methodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.

Madeline McCoy (M)

Methodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.

Gordon Fernie (G)

Methodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.

Lauralyn McIntyre (L)

Methodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.
Department of Critical Care, The Ottawa Hospital, Ottawa, ON, Canada.
Department of Medicine, University of Ottawa, Ottawa, ON, Canada.

Anthony Delaney (A)

Malcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, Sydney, Australia.
Critical Care Program, The George Institute for Global Health, University of New South Wales Sydney, Sydney, Australia.
Northern Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.

Michaël Chassé (M)

Department of Medicine, Division of Critical Care, Centre Hospitalier de L'Université de Montréal, Montréal, Québec, Canada.

Victoria Saigle (V)

Methodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.

Shawn Marshall (S)

Methodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Department of Medicine, University of Ottawa, Ottawa, ON, Canada.

Dean A Fergusson (DA)

Methodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Department of Critical Care, The Ottawa Hospital, Ottawa, ON, Canada.

Ian Graham (I)

Methodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.

Jamie Brehaut (J)

Methodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.

Alexis F Turgeon (AF)

Department of Anesthesiology and Critical Care, Division of Critical Care Medicine, Université Laval, Québec City, Québec, Canada.
Population Health and Optimal Health Practice Research Unit (Trauma - Emergency - Critical Care Medicine) CHU de Québec-Université Laval Research Centre, Québec City, Québec, Canada.

François Lauzier (F)

Population Health and Optimal Health Practice Research Unit (Trauma - Emergency - Critical Care Medicine) CHU de Québec-Université Laval Research Centre, Québec City, Québec, Canada.
Department of Medicine, Department of Anesthesiology and Critical Care, Université Laval, Québec, Canada.

Peter Tugwell (P)

Methodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.
Department of Medicine, University of Ottawa, Ottawa, ON, Canada.
Bruyère Research Institute, Ottawa, ON, Canada.

Xiaohui Zha (X)

Inflammation and Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Canada.
Department of Biochemistry, Immunology & Microbiology, University of Ottawa, Ottawa, Canada.

Phil Talbot (P)

Critical Care Program, The George Institute for Global Health, University of New South Wales Sydney, Sydney, Australia.

John Muscedere (J)

Department of Critical Care Medicine, Queen's University, Kingston, ON, Canada.

John C Marshall (JC)

Departments of Surgery and Critical Care Medicine, Unity Health Toronto, Toronto, ON, Canada.

Kednapa Thavorn (K)

Methodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.

Donald Griesdale (D)

Department of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, BC, Canada.
Centre for Clinical Epidemiology & Evaluation, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.

Shane W English (SW)

Methodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada. senglish@toh.ca.
School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada. senglish@toh.ca.
Department of Critical Care, The Ottawa Hospital, Ottawa, ON, Canada. senglish@toh.ca.
Department of Medicine, University of Ottawa, Ottawa, ON, Canada. senglish@toh.ca.

Classifications MeSH