An altered uterine microbiota with endometrial hyperplasia.
Delftia
Serratia
Stenotrophomonas
16S rDNA
Endometrial hyperplasia
Microbiome
Uterus
Journal
BMC microbiology
ISSN: 1471-2180
Titre abrégé: BMC Microbiol
Pays: England
ID NLM: 100966981
Informations de publication
Date de publication:
12 Jul 2024
12 Jul 2024
Historique:
received:
24
05
2023
accepted:
17
06
2024
medline:
13
7
2024
pubmed:
13
7
2024
entrez:
12
7
2024
Statut:
epublish
Résumé
Endometrial hyperplasia (EH) is a precursor to endometrial cancer, and the role of the microbiome in its development is unclear. The present study investigated the uterine microbiome in patients with benign uterine conditions and endometrial hyperplasia. A significant structural shift in the uterine microbiome of patients with endometrial hyperplasia compared to those with benign conditions was found. Delftia, Serratia and Stenotrophomonas were significantly enriched in endometrial hyperplasia samples and associated with the presence of endometrial hyperplasia. The novel finding suggested that increased abundance of Delftia, Serratia and Stenotrophomonas is associated with the presence of endometrial hyperplasia. Further investigation is needed to determine the value of these microbes as biomarkers for endometrial hyperplasia.
Sections du résumé
BACKGROUND
BACKGROUND
Endometrial hyperplasia (EH) is a precursor to endometrial cancer, and the role of the microbiome in its development is unclear.
RESULTS
RESULTS
The present study investigated the uterine microbiome in patients with benign uterine conditions and endometrial hyperplasia. A significant structural shift in the uterine microbiome of patients with endometrial hyperplasia compared to those with benign conditions was found. Delftia, Serratia and Stenotrophomonas were significantly enriched in endometrial hyperplasia samples and associated with the presence of endometrial hyperplasia.
CONCLUSIONS
CONCLUSIONS
The novel finding suggested that increased abundance of Delftia, Serratia and Stenotrophomonas is associated with the presence of endometrial hyperplasia. Further investigation is needed to determine the value of these microbes as biomarkers for endometrial hyperplasia.
Identifiants
pubmed: 38997629
doi: 10.1186/s12866-024-03379-1
pii: 10.1186/s12866-024-03379-1
doi:
Substances chimiques
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
258Subventions
Organisme : Natural Science Foundation of Zhejiang Province
ID : LGF22H040011
Organisme : Natural Science Foundation of Zhejiang Province
ID : LGF22H040011
Organisme : the Health Commission of Zhejiang Province
ID : 2022KY857
Organisme : the Health Commission of Zhejiang Province
ID : 2022KY857
Organisme : Zhejiang Provincial Department of Education
ID : Y202146852
Informations de copyright
© 2024. The Author(s).
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