The integrin receptor beta
Animals
Mice, Inbred C57BL
Airway Remodeling
/ physiology
Mice, Knockout
Mice
Ovalbumin
/ toxicity
Integrin beta Chains
/ metabolism
Allergens
/ immunology
Cells, Cultured
Bronchial Hyperreactivity
/ immunology
Lung
/ metabolism
Disease Models, Animal
Fibroblasts
/ metabolism
Transforming Growth Factor beta
/ metabolism
Airway-hyperresponsiveness
Asthma
Fibroblast
Remodeling
α4β7 integrin
Journal
Respiratory research
ISSN: 1465-993X
Titre abrégé: Respir Res
Pays: England
ID NLM: 101090633
Informations de publication
Date de publication:
12 Jul 2024
12 Jul 2024
Historique:
received:
27
12
2023
accepted:
29
06
2024
medline:
13
7
2024
pubmed:
13
7
2024
entrez:
12
7
2024
Statut:
epublish
Résumé
Fibroblast differentiation to a myofibroblast phenotype is a feature of airway remodeling in asthma. Lung fibroblasts express the integrin receptor α To investigate the role of the β7 integrin receptor subunit and α C57BL/6 wild type (WT) and β7 integrin null mice (β Eosinophil numbers were similar in WT vs β7-/- mice. Prolonged OVA exposure in β7-/- mice was associated with reduced AHR, lung collagen content, peribronchial smooth muscle, lung tissue TGFβ and IL13 expression as compared to WT. Similar findings were observed in WT mice treated with α The β7 integrin subunit and the α4β7 integrin complex modulate AHR and airway remodeling in a murine model of allergen exposure. This effect is, at least in part, explained by inhibition of fibroblast activation and is independent of eosinophilic inflammation.
Sections du résumé
BACKGROUND
BACKGROUND
Fibroblast differentiation to a myofibroblast phenotype is a feature of airway remodeling in asthma. Lung fibroblasts express the integrin receptor α
OBJECTIVES
OBJECTIVE
To investigate the role of the β7 integrin receptor subunit and α
METHODS
METHODS
C57BL/6 wild type (WT) and β7 integrin null mice (β
RESULTS
RESULTS
Eosinophil numbers were similar in WT vs β7-/- mice. Prolonged OVA exposure in β7-/- mice was associated with reduced AHR, lung collagen content, peribronchial smooth muscle, lung tissue TGFβ and IL13 expression as compared to WT. Similar findings were observed in WT mice treated with α
CONCLUSIONS
CONCLUSIONS
The β7 integrin subunit and the α4β7 integrin complex modulate AHR and airway remodeling in a murine model of allergen exposure. This effect is, at least in part, explained by inhibition of fibroblast activation and is independent of eosinophilic inflammation.
Identifiants
pubmed: 38997751
doi: 10.1186/s12931-024-02899-8
pii: 10.1186/s12931-024-02899-8
doi:
Substances chimiques
Ovalbumin
9006-59-1
Integrin beta Chains
0
Allergens
0
integrin beta7
0
Transforming Growth Factor beta
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
273Subventions
Organisme : Ministry of Health, State of Israel
ID : 3-0000-11030
Informations de copyright
© 2024. The Author(s).
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