Resilience after severe critical illness: a prospective, multicentre, observational study (RESIREA).

Humans Prospective Studies Male Female Critical Illness / psychology Middle Aged Resilience, Psychological Stress Disorders, Post-Traumatic / psychology Aged Quality of Life / psychology Surveys and Questionnaires Intensive Care Units / organization & administration France Adult Social Support
Critical illness Illness perception Post-traumatic stress disorder Quality of life Resilience Social support

Journal

Critical care (London, England)
ISSN: 1466-609X
Titre abrégé: Crit Care
Pays: England
ID NLM: 9801902

Informations de publication

Date de publication:
12 Jul 2024
Historique:
received: 13 03 2024
accepted: 14 06 2024
medline: 13 7 2024
pubmed: 13 7 2024
entrez: 12 7 2024
Statut: epublish

Résumé

Critical-illness survivors may experience post-traumatic stress disorder (PTSD) and quality-of-life impairments. Resilience may protect against psychological trauma but has not been adequately studied after critical illness. We assessed resilience and its associations with PTSD and quality of life, and also identified factors associated with greater resilience. This prospective, multicentre, study in patients recruited at 41 French ICUs was done in parallel with the NUTRIREA-3 trial in patients given mechanical ventilation and vasoactive amines for shock. Three months to one year after intensive-care-unit admission, survivors completed the Connor-Davidson Resilience Scale (CD-RISC-25), Impact of Event-Revised scale for PTSD symptoms (IES-R), SF-36 quality-of-life scale, Multidimensional Scale of Perceived Social Support (MSPSS), and Brief Illness Perception Questionnaire (B-IPQ). Of the 382 included patients, 203 (53.1%) had normal or high resilience (CD-RISC-25 ≥ 68). Of these resilient patients, 26 (12.8%) had moderate to severe PTSD symptoms (IES-R ≥ 24) vs. 45 (25.4%) patients with low resilience (p = 0.002). Resilient patients had higher SF-36 scores. Factors independently associated with higher CD-RISC-25 scores were higher MSPSS score indicating stronger social support (OR, 1.027; 95%CI 1.008-1.047; p = 0.005) and lower B-IPQ scores indicating a more threatening perception of the illness (OR, 0.973; 95%CI 0.950-0.996; p = 0.02). Resilient patients had a lower prevalence of PTSD symptoms and higher quality of life scores, compared to patients with low resilience. Higher scores for social support and illness perception were independently associated with greater resilience. Thus, our findings suggest that interventions to strengthen social support and improve illness perception may help to improve resilience. Such interventions should be evaluated in trials with PTSD mitigation and quality-of-life improvement as the target outcomes.

Sections du résumé

BACKGROUND BACKGROUND
Critical-illness survivors may experience post-traumatic stress disorder (PTSD) and quality-of-life impairments. Resilience may protect against psychological trauma but has not been adequately studied after critical illness. We assessed resilience and its associations with PTSD and quality of life, and also identified factors associated with greater resilience.
METHODS METHODS
This prospective, multicentre, study in patients recruited at 41 French ICUs was done in parallel with the NUTRIREA-3 trial in patients given mechanical ventilation and vasoactive amines for shock. Three months to one year after intensive-care-unit admission, survivors completed the Connor-Davidson Resilience Scale (CD-RISC-25), Impact of Event-Revised scale for PTSD symptoms (IES-R), SF-36 quality-of-life scale, Multidimensional Scale of Perceived Social Support (MSPSS), and Brief Illness Perception Questionnaire (B-IPQ).
RESULTS RESULTS
Of the 382 included patients, 203 (53.1%) had normal or high resilience (CD-RISC-25 ≥ 68). Of these resilient patients, 26 (12.8%) had moderate to severe PTSD symptoms (IES-R ≥ 24) vs. 45 (25.4%) patients with low resilience (p = 0.002). Resilient patients had higher SF-36 scores. Factors independently associated with higher CD-RISC-25 scores were higher MSPSS score indicating stronger social support (OR, 1.027; 95%CI 1.008-1.047; p = 0.005) and lower B-IPQ scores indicating a more threatening perception of the illness (OR, 0.973; 95%CI 0.950-0.996; p = 0.02).
CONCLUSIONS CONCLUSIONS
Resilient patients had a lower prevalence of PTSD symptoms and higher quality of life scores, compared to patients with low resilience. Higher scores for social support and illness perception were independently associated with greater resilience. Thus, our findings suggest that interventions to strengthen social support and improve illness perception may help to improve resilience. Such interventions should be evaluated in trials with PTSD mitigation and quality-of-life improvement as the target outcomes.

Identifiants

DOI: 10.1186/s13054-024-04989-x PMID: 38997759
pubmed: 38997759
doi: 10.1186/s13054-024-04989-x
pii: 10.1186/s13054-024-04989-x
doi:

Types de publication

Journal Article Multicenter Study Observational Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

237

Informations de copyright

© 2024. The Author(s).

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Auteurs

Alice Mathieu (A)

Laboratoire de Psychologie: Dynamiques Relationnelles Et Processus Identitaires (Psy-DREPI), Université de Bourgogne Franche-Comté, EA7458, Dijon, France.

Jean Reignier (J)

CHU Nantes, Movement - Interactions - Performance, MIP, UR 4334, Nantes Université, 44000, Nantes, France. jean.reignier@chu-nantes.fr.
Médecine Intensive Réanimation, Nantes Université, CHU Nantes, 44000, Nantes, France. jean.reignier@chu-nantes.fr.
Service de Médecine Intensive Réanimation, Centre Hospitalier Universitaire Hôtel-Dieu, 30 Bd. Jean Monnet, 44093, Nantes Cedex 1, France. jean.reignier@chu-nantes.fr.

Amélie Le Gouge (A)

Inserm CIC 1415, Tours, France.
Centre Hospitalier Universitaire de Tours, Tours, France.

Gaetan Plantefeve (G)

Service de Médecine Intensive Réanimation, Centre Hospitalier d'Argenteuil, Argenteuil, France.

Jean-Paul Mira (JP)

Service de Médecine Intensive Réanimation, Hôpital Cochin, Groupe Hospitalier Paris Centre-Université Paris Cité, Assistance Publique -Hôpitaux de Paris, Paris, France.

Laurent Argaud (L)

Service de Médecine Intensive Réanimation, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.

Pierre Asfar (P)

Service de Médecine Intensive Réanimation, Centre Hospitalier Universitaire Angers, Angers, France.

Julio Badie (J)

Service de Médecine Intensive Réanimation, Hôpital Nord Franche Comté, Trevenans, France.

Nicolae-Vlad Botoc (NV)

Service de Médecine Intensive Réanimation, Centre Hospitalier de Saint Malo, Saint-Malo, France.

Hoang-Nam Bui (HN)

Service de Médecine Intensive Réanimation, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.

Delphine Chatellier (D)

Service de Médecine Intensive Réanimation, Centre Hospitalier Universitaire de Poitiers, Poitiers, France.

Louis Chauvelot (L)

Service de Médecine Intensive Réanimation, Hôpital de la Croix Rousse, Hospices Civils de Lyon, Lyon, France.

Christophe Cracco (C)

Service de Médecine Intensive Réanimation, Centre Hospitalier d'Angoulême, Angoulême, France.

Michael Darmon (M)

Université Paris Cité ; Assistance Publique -Hôpitaux de Paris, Service de Médecine Intensive Réanimation, Centre Hospitalier Universitaire Saint Louis, Paris, France.

Agathe Delbove (A)

Service de Réanimation Polyvalente, Centre Hospitalier Bretagne-Atlantique, Vannes, France.

Jérôme Devaquet (J)

Service de Réanimation Polyvalente, Hôpital Foch, Suresnes, France.

Louis-Marie Dumont (LM)

Service de Médecine Intensive Réanimation, Hôpital Louis-Mourier, Assistance Publique -Hôpitaux de Paris, Colombes, France.

Olivier Gontier (O)

Service de Médecine Intensive Réanimation, Centre Hospitalier de Chartres, Chartres, France.

Samuel Groyer (S)

Service de Médecine Intensive Réanimation, Centre Hospitalier de Montauban, Montauban, France.

Yannick Hourmant (Y)

CHU Nantes, INSERM, Nantes Université, Anesthesie Reanimation, CIC 1413, Nantes, France.

Samir Jaber (S)

Service de Réanimation Chirurgicale, Hôpital Saint-Eloi, CHU de Montpellier, Montpellier, France.
PhyMedExp, INSERM, CNRS, Montpellier, France.

Fabien Lambiotte (F)

Service de Médecine Intensive Réanimation, Centre Hospitalier de Valenciennes, Valenciennes, France.

Benjamin Madeux (B)

Service de Médecine Intensive Réanimation, Centre Hospitalier de Bigorre, Tarbes, France.

Julien Maizel (J)

Service de Médecine Intensive Réanimation, Centre Hospitalier Universitaire Amiens-Picardie, Amiens, France.

Olivier Martinet (O)

Service de Médecine Intensive Réanimation, Centre Hospitalier Universitaire de la Réunion, Saint-Denis, La Réunion, France.

Virginie Maxime (V)

Service de Médecine Intensive Réanimation, Hôpital Raymond Poincaré, Assistance Publique Hôpitaux de Paris, Garches, France.
Inserm U 1173, Université de Versailles-Saint Quentin en Yvelines, Versailles, France.

Emmanuelle Mercier (E)

Service de Médecine Intensive Réanimation, Centre Hospitalier Universitaire de Tours, CRICS-TRIGGERSEP Network Tours, Tours, France.

Mai-Anh Nay (MA)

Service de Médecine Intensive Réanimation, Centre Hospitalier Universitaire d'Orléans, Orléans, France.

Saad Nseir (S)

Médecine Intensive-Réanimation, CHU Lille, 59000, Lille, France.
CNRS, Inserm, UMR 8576 - U1285 - UGSF - Unité de Glycobiologie Structurale et Fonctionnelle, Lille University, Lille, France.

Gael Piton (G)

Service de Médecine Intensive Réanimation, Centre Hospitalier Universitaire de Besançon, Besançon, France.
Université de Franche Comté, EA3920, Besançon, France.

Jean-Pierre Quenot (JP)

Service de Médecine Intensive Réanimation, Centre Hospitalier Universitaire François Mitterrand, Dijon, France.
Lipness Team, INSERM, LabExLipSTIC, Université de Bourgogne, Dijon, France.
INSERM Centres d'Investigation Clinique, Département d'épidémiologie Clinique, Université de Bourgogne, Dijon, France.

Anne Renault (A)

Service de Médecine Intensive Réanimation, Centre Hospitalier Universitaire La Cavale Blanche, Brest, France.

Jean-Philippe Rigaud (JP)

Service de Médecine Intensive Réanimation, Centre Hospitalier de Dieppe, Dieppe, France.

Francis Schneider (F)

Service de Médecine Intensive Réanimation, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.

Michel Sirodot (M)

Service de Médecine Intensive Réanimation, Centre Hospitalier Annecy Genevois, Epagny Metz-Tessy, France.

Bertrand Souweine (B)

Service de Médecine Intensive Réanimation, Centre Hospitalier Universitaire Gabriel-Montpied, Clermont-Ferrand, France.

Fabienne Tamion (F)

Service de Médecine Intensive Réanimation, Hôpital Charles Nicolle, Centre Hospitalier Universitaire de Rouen; Normandie Université, UNIROUEN, Inserm U1096, FHU-REMOD-VHF, Rouen, France.

Didier Thévenin (D)

Service de Médecine Intensive Réanimation, Centre Hospitalier de Lens, Lens, France.

Nathalie Thieulot-Rolin (N)

Service de Médecine Intensive Réanimation, Groupe Hospitalier Sud Ile de France, Melun, France.

Francois Tinturier (F)

Service de Réanimation Chirurgicale, Centre Hospitalier Universitaire Amiens-Picardie, Amiens, France.

Patrice Tirot (P)

Service de Médecine Intensive Réanimation, Centre Hospitalier du Mans, Le Mans, France.

Isabelle Vinatier (I)

Service de Médecine Intensive Réanimation, Centre Hospitalier Départemental de la Vendée, La Roche sur Yon, France.

Christophe Vinsonneau (C)

Service de Médecine Intensive Réanimation, Centre Hospitalier de Béthune, Béthune, France.

Jean-Baptiste Lascarrou (JB)

CHU Nantes, Movement - Interactions - Performance, MIP, UR 4334, Nantes Université, 44000, Nantes, France.
Médecine Intensive Réanimation, Nantes Université, CHU Nantes, 44000, Nantes, France.

Alexandra Laurent (A)

Laboratoire de Psychologie: Dynamiques Relationnelles Et Processus Identitaires (Psy-DREPI), Université de Bourgogne Franche-Comté, EA7458, Dijon, France. alexandra.laurent@u-bourgogne.fr.
Department of Anaesthesiology and Critical Care Medicine, Dijon University Medical Centre, Dijon, France. alexandra.laurent@u-bourgogne.fr.
Laboratoire Psy-DREPI, Université de Bourgogne Pôle Aafe, Esplanade Erasme, 21078, Dijon, France. alexandra.laurent@u-bourgogne.fr.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Resilience after severe critical illness: a...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Resilience after severe critical illness: a...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie grave › Resilience after severe critical illness: a...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Resilience after severe critical illness: a...
questionsmedicales.fr › Phénomènes psychologiques › Résilience psychologique › Resilience after severe critical illness: a...
questionsmedicales.fr › Troubles mentaux › Troubles liés aux traumatismes et au stress › Troubles de stress traumatique › Troubles de stress post-traumatique › Resilience after severe critical illness: a...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Resilience after severe critical illness: a...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Qualité de vie › Resilience after severe critical illness: a...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Resilience after severe critical illness: a...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Établissements de santé › Unités hospitalières › Unités de soins intensifs › Resilience after severe critical illness: a...
questionsmedicales.fr › Régions géographiques › Europe › France › Resilience after severe critical illness: a...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Resilience after severe critical illness: a...
questionsmedicales.fr › Sciences sociales › Sociologie › Facteurs sociologiques › Environnement social › Soutien social › Resilience after severe critical illness: a...