Effect of luteolin on oxidative stress and inflammation in the human osteoblast cell line hFOB1.19 in an inflammatory microenvironment.
Luteolin
/ pharmacology
Humans
Oxidative Stress
/ drug effects
Osteoblasts
/ drug effects
Hydrogen Peroxide
/ toxicity
Inflammation
/ drug therapy
Cell Line
Anti-Inflammatory Agents
/ pharmacology
Apoptosis
/ drug effects
Reactive Oxygen Species
/ metabolism
Lipopolysaccharides
/ pharmacology
Cell Proliferation
/ drug effects
Antioxidants
/ pharmacology
NF-kappa B
/ metabolism
Cellular Microenvironment
/ drug effects
Cytokines
/ metabolism
Chronic apical periodontitis
Inflammation
Luteolin
NF-κB signalling pathway
Oxidative stress
Journal
BMC pharmacology & toxicology
ISSN: 2050-6511
Titre abrégé: BMC Pharmacol Toxicol
Pays: England
ID NLM: 101590449
Informations de publication
Date de publication:
12 Jul 2024
12 Jul 2024
Historique:
received:
01
05
2023
accepted:
05
07
2024
medline:
13
7
2024
pubmed:
13
7
2024
entrez:
12
7
2024
Statut:
epublish
Résumé
Periapical lesions are characterized by periapical inflammation and damage to periapical tissues and eventually lead to bone resorption and even tooth loss. H After human osteoblasts (hFOB1.19) were treated with lipopolysaccharide (LPS), luteolin, or H We demonstrated that inflammation is closely related to oxidative stress and that the oxidative stress level in the inflammatory environment is increased. Luteolin inhibited the H We elucidated that luteolin protected human osteoblasts (hFOB1.19) from H
Sections du résumé
BACKGROUND
BACKGROUND
Periapical lesions are characterized by periapical inflammation and damage to periapical tissues and eventually lead to bone resorption and even tooth loss. H
METHODS
METHODS
After human osteoblasts (hFOB1.19) were treated with lipopolysaccharide (LPS), luteolin, or H
RESULTS
RESULTS
We demonstrated that inflammation is closely related to oxidative stress and that the oxidative stress level in the inflammatory environment is increased. Luteolin inhibited the H
CONCLUSION
CONCLUSIONS
We elucidated that luteolin protected human osteoblasts (hFOB1.19) from H
Identifiants
pubmed: 38997762
doi: 10.1186/s40360-024-00764-4
pii: 10.1186/s40360-024-00764-4
doi:
Substances chimiques
Luteolin
KUX1ZNC9J2
Hydrogen Peroxide
BBX060AN9V
Anti-Inflammatory Agents
0
Reactive Oxygen Species
0
Lipopolysaccharides
0
Antioxidants
0
NF-kappa B
0
Cytokines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
40Subventions
Organisme : National Natural Science Foundation of China
ID : 81800954
Informations de copyright
© 2024. The Author(s).
Références
Braz-Silva PH, Bergamini ML, Mardegan AP, De Rosa CS, Hasseus B, Jonasson P. Inflammatory profile of chronic apical periodontitis: a literature review. Acta Odontol Scand. 2019;77(3):173–80.
pubmed: 30585523
doi: 10.1080/00016357.2018.1521005
Karteva T, Manchorova-Veleva N. The role of the immune response in chronic marginal and apical periodontitis. Folia Medica. 2020;62(2):238–43.
pubmed: 32666754
doi: 10.3897/folmed.62.e39599
Dal-Fabbro R, Marques-de-Almeida M, Cosme-Silva L, Ervolino E, Cintra LTA, Gomes-Filho JE. Chronic alcohol consumption increases inflammation and osteoclastogenesis in apical periodontitis. Int Endod J. 2019;52(3):329–36.
pubmed: 30218448
doi: 10.1111/iej.13014
Li X, Han X, Yu W, Chen X, Wu Y, Lu L. Correlation between transforming growth factor-β and periapical lesions in patients with chronic apical periodontitis. J Healthc Eng. 2022;2022:2173434.
pubmed: 35360476
pmcid: 8964188
Barnes PJ. Oxidative stress-based therapeutics in COPD. Redox Biol. 2020;33:101544.
pubmed: 32336666
pmcid: 7251237
doi: 10.1016/j.redox.2020.101544
Zhao XJ, Yu HW, Yang YZ, Wu WY, Chen TY, Jia KK, et al. Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway. Redox Biol. 2018;18:124–37.
pubmed: 30014902
pmcid: 6068203
doi: 10.1016/j.redox.2018.07.002
Sul OJ, Ra SW. Quercetin prevents LPS-induced oxidative stress and inflammation by modulating NOX2/ROS/NF-kB in lung epithelial cells. Molecules. 2021;26(22).
Zhou Y, Que KT, Zhang Z, Yi ZJ, Zhao PX, You Y, et al. Iron overloaded polarizes macrophage to proinflammation phenotype through ROS/acetyl-p53 pathway. Cancer Med. 2018;7(8):4012–22.
pubmed: 29989329
pmcid: 6089144
doi: 10.1002/cam4.1670
Lin LM, Ricucci D, Lin J, Rosenberg PA. Nonsurgical root canal therapy of large cyst-like inflammatory periapical lesions and inflammatory apical cysts. J Endod. 2009;35(5):607–15.
pubmed: 19410070
doi: 10.1016/j.joen.2009.02.012
Song J, Hong L, Zou X, Alshawwa H, Zhao Y, Zhao H, et al. A self-supplying H(2)O(2) modified nanozyme-loaded hydrogel for root canal biofilm eradication. Int J Mol Sci. 2022;23(17).
Minczykowski A, Woszczyk M, Szczepanik A, Lewandowski L, Wysocki H. Hydrogen peroxide and superoxide anion production by polymorphonuclear neutrophils in patients with chronic periapical granuloma, before and after surgical treatment. Clin Oral Invest. 2001;5(1):6–10.
doi: 10.1007/s007840000095
Imran M, Rauf A, Abu-Izneid T, Nadeem M, Shariati MA, Khan IA, et al. Luteolin, a flavonoid, as an anticancer agent: a review. Biomed Pharmacother. 2019;112:108612.
Franza L, Carusi V, Nucera E, Pandolfi F. Luteolin, inflammation and cancer: special emphasis on gut microbiota. BioFactors. 2021;47(2):181–9.
pubmed: 33507594
doi: 10.1002/biof.1710
Gendrisch F, Esser PR, Schempp CM, Wölfle U. Luteolin as a modulator of skin aging and inflammation. BioFactors. 2021;47(2):170–80.
pubmed: 33368702
doi: 10.1002/biof.1699
Liu L, Peng Z, Xu Z, Wei X. Effect of luteolin and apigenin on the expression of Oct-4, Sox2, and c-Myc in dental pulp cells with in vitro culture. Biomed Res Int. 2015;2015:534952.
pubmed: 25815323
pmcid: 4357035
Wang S, Cao M, Xu S, Shi J, Mao X, Yao X, et al. Luteolin alters macrophage polarization to inhibit inflammation. Inflammation. 2020;43(1):95–108.
pubmed: 31673976
doi: 10.1007/s10753-019-01099-7
Zhao M, Wang Y, Li L, Liu S, Wang C, Yuan Y, et al. Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance. Theranostics. 2021;11(4):1845–63.
pubmed: 33408785
pmcid: 7778599
doi: 10.7150/thno.50905
Mittal M, Siddiqui MR, Tran K, Reddy SP, Malik AB. Reactive oxygen species in inflammation and tissue injury. Antioxid Redox Signal. 2014;20(7):1126–67.
pubmed: 23991888
pmcid: 3929010
doi: 10.1089/ars.2012.5149
Lai JL, Liu YH, Liu C, Qi MP, Liu RN, Zhu XF, et al. Indirubin inhibits LPS-Induced inflammation via TLR4 abrogation mediated by the NF-kB and MAPK signaling pathways. Inflammation. 2017;40(1):1–12.
pubmed: 27718095
doi: 10.1007/s10753-016-0447-7
Mitchell JP, Carmody RJ. NF-κB and the transcriptional control of inflammation. Int Rev cell Mol Biol. 2018;335:41–84.
doi: 10.1016/bs.ircmb.2017.07.007
Kwon T, Lamster IB, Levin L. Current concepts in the management of periodontitis. Int Dent J. 2021;71(6):462–76.
pubmed: 34839889
pmcid: 9275292
doi: 10.1111/idj.12630
Zhang H, Liu L, Jiang C, Pan K, Deng J, Wan C. MMP9 protects against LPS-induced inflammation in osteoblasts. Innate Immun. 2020;26(4):259–69.
pubmed: 31726909
doi: 10.1177/1753425919887236
Wang L, Dong M, Shi D, Yang C, Liu S, Gao L, et al. Role of PI3K in the bone resorption of apical periodontitis. BMC Oral Health. 2022;22(1):345.
pubmed: 35953782
pmcid: 9373278
doi: 10.1186/s12903-022-02364-2
Zhang P, Feng Q, Chen W, Bai X. Catalpol antagonizes LPS-mediated inflammation and promotes osteoblast differentiation through the miR-124-3p/DNMT3b/TRAF6 axis. Acta Histochem. 2024;126(1):152118.
pubmed: 38039796
doi: 10.1016/j.acthis.2023.152118
Wu HH, Guo Y, Pu YF, Tang ZH. Adiponectin inhibits lipoplysaccharide-induced inflammation and promotes osteogenesis in hPDLCs. Biosci Rep. 2021;41(3).
Kocic B, Kitic D, Brankovic S. Dietary flavonoid intake and colorectal cancer risk: evidence from human population studies. J BUON. 2013;18(1):34–43.
Lin Y, Shi R, Wang X, Shen HM. Luteolin, a flavonoid with potential for cancer prevention and therapy. Curr Cancer Drug Targets. 2008;8(7):634–46.
pubmed: 18991571
pmcid: 2615542
doi: 10.2174/156800908786241050
Ganai SA, Sheikh FA, Baba ZA, Mir MA, Mantoo MA, Yatoo MA. Anticancer activity of the plant flavonoid luteolin against preclinical models of various cancers and insights on different signalling mechanisms modulated. Phytother Res. 2021;35(7):3509–32.
pubmed: 33580629
doi: 10.1002/ptr.7044
Liu Z, Gao S, Bu Y, Zheng X. Luteolin protects cardiomyocytes cells against lipopolysaccharide-induced apoptosis and inflammatory damage by modulating Nlrp3. Yonsei Med J. 2022;63(3):220–8.
pubmed: 35184424
pmcid: 8860941
doi: 10.3349/ymj.2022.63.3.220
Kou JJ, Shi JZ, He YY, Hao JJ, Zhang HY, Luo DM, et al. Luteolin alleviates cognitive impairment in Alzheimer’s disease mouse model via inhibiting endoplasmic reticulum stress-dependent neuroinflammation. Acta Pharmacol Sin. 2022;43(4):840–9.
pubmed: 34267346
doi: 10.1038/s41401-021-00702-8
Zheng Y, Li L, Chen H, Zheng Y, Tan X, Zhang G, et al. Luteolin exhibits synergistic therapeutic efficacy with erastin to induce ferroptosis in colon cancer cells through the HIC1-mediated inhibition of GPX4 expression. Free Radic Biol Med. 2023;208:530–44.
pubmed: 37717793
doi: 10.1016/j.freeradbiomed.2023.09.014
Yoo HS, Won SB, Kwon YH. Luteolin induces apoptosis and autophagy in HCT116 colon cancer cells via p53-dependent pathway. Nutr Cancer. 2022;74(2):677–86.
pubmed: 33757400
doi: 10.1080/01635581.2021.1903947
Fasoulakis Z, Koutras A, Syllaios A, Schizas D, Garmpis N, Diakosavvas M, et al. Breast cancer apoptosis and the therapeutic role of Luteolin. Chirurgia. 2021;116(2):170–7.
pubmed: 33950812
doi: 10.21614/chirurgia.116.2.170
Li L, Zhou R, Lv H, Song L, Xue X, Wu L. Inhibitive effect of luteolin on sevoflurane-induced neurotoxicity through activation of the autophagy pathway by HMOX1. ACS Chem Neurosci. 2021;12(18):3314–22.
pubmed: 34445868
doi: 10.1021/acschemneuro.1c00157
Sun WL, Yang JW, Dou HY, Li GQ, Li XY, Shen L, et al. Anti-inflammatory effect of luteolin is related to the changes in the gut microbiota and contributes to preventing the progression from simple steatosis to nonalcoholic steatohepatitis. Bioorg Chem. 2021;112:104966.
pubmed: 33991837
doi: 10.1016/j.bioorg.2021.104966
Abbasi N, Khosravi A, Aidy A, Shafiei M. Biphasic response to Luteolin in MG-63 osteoblast-like cells under high glucose-induced oxidative stress. Iran J Med Sci. 2016;41(2):118–25.
pubmed: 26989282
Choi EM. Luteolin protects osteoblastic MC3T3-E1 cells from antimycin A-induced cytotoxicity through the improved mitochondrial function and activation of PI3K/Akt/CREB. Toxicol In Vitro. 2011;25(8):1671–9.
Suh KS, Chon S, Choi EM. Luteolin alleviates methylglyoxal-induced cytotoxicity in osteoblastic MC3T3-E1 cells. Cytotechnology. 2016;68(6):2539–52.
pubmed: 27221336
pmcid: 5101326
doi: 10.1007/s10616-016-9977-y
Ma Y, Tang T, Sheng L, Wang Z, Tao H, Zhang Q, et al. Aloin suppresses lipopolysaccharide–induced inflammation by inhibiting JAK1–STAT1/3 activation and ROS production in RAW264.7 cells. Int J Mol Med. 2018;42(4):1925–34.
pubmed: 30066904
pmcid: 6108888
Ohl K, Tenbrock K. Reactive oxygen species as regulators of MDSC-mediated immune suppression. Front Immunol. 2018;9:2499.
pubmed: 30425715
pmcid: 6218613
doi: 10.3389/fimmu.2018.02499
Mao W, Xiong G, Wu Y, Wang C, St Clair D, Li JD et al. RORα suppresses cancer-associated inflammation by repressing respiratory complex I-dependent ROS generation. Int J Mol Sci. 2021;22(19).
Hong G, Chen Z, Han X, Zhou L, Pang F, Wu R, et al. A novel RANKL-targeted flavonoid glycoside prevents osteoporosis through inhibiting NFATc1 and reactive oxygen species. Clin Translational Med. 2021;11(5):e392.
doi: 10.1002/ctm2.392
Li M, Hao L, Li L, Liu L, Chen G, Jiang W, et al. Cinnamtannin B-1 prevents ovariectomy-induced osteoporosis via attenuating osteoclastogenesis and ROS generation. Front Pharmacol. 2020;11:1023.
pubmed: 32754032
pmcid: 7365944
doi: 10.3389/fphar.2020.01023
Sczepanik FSC, Grossi ML, Casati M, Goldberg M, Glogauer M, Fine N, et al. Periodontitis is an inflammatory disease of oxidative stress: we should treat it that way. Periodontol 2000. 2020;84(1):45–68.
pubmed: 32844417
doi: 10.1111/prd.12342
Zhao Y, Li J, Guo W, Li H, Lei L. Periodontitis-level butyrate-induced ferroptosis in periodontal ligament fibroblasts by activation of ferritinophagy. Cell Death Discov. 2020;6(1):119.
pubmed: 33298848
pmcid: 7655826
doi: 10.1038/s41420-020-00356-1
Sui L, Wang J, Xiao Z, Yang Y, Yang Z, Ai K. ROS-scavenging nanomaterials to treat periodontitis. Front Chem. 2020;8:595530.
pubmed: 33330384
pmcid: 7672210
doi: 10.3389/fchem.2020.595530
Weng Y, Wang H, Li L, Feng Y, Xu S, Wang Z. Trem2 mediated syk-dependent ROS amplification is essential for osteoclastogenesis in periodontitis microenvironment. Redox Biol. 2021;40:101849.
pubmed: 33486152
doi: 10.1016/j.redox.2020.101849
Zhang B, Yang Y, Yi J, Zhao Z, Ye R. Hyperglycemia modulates M1/M2 macrophage polarization via reactive oxygen species overproduction in ligature-induced periodontitis. J Periodontal Res. 2021;56(5):991–1005.
pubmed: 34190354
doi: 10.1111/jre.12912
Ran C, Yu B, Yin H, Yang Y, Wu H, Yin Q. Hugan Buzure Granule alleviates acute kidney Injury in mice by inhibiting NLRP3/Caspase-1 pathway and TLR4/NF-κB pathway. FBL. 2023;28(11).
Thoma A, Lightfoot AP. NF-kB and inflammatory cytokine signalling: role in skeletal muscle atrophy. Adv Exp Med Biol. 2018;1088:267–79.
pubmed: 30390256
doi: 10.1007/978-981-13-1435-3_12
Moniruzzaman M, Ghosal I, Das D, Chakraborty SB. Melatonin ameliorates H(2)O(2)-induced oxidative stress through modulation of Erk/Akt/NFkB pathway. Biol Res. 2018;51(1):17.
pubmed: 29891016
pmcid: 5996524
doi: 10.1186/s40659-018-0168-5
Guan X, He Y, Wei Z, Shi C, Li Y, Zhao R, et al. Crosstalk between Wnt/β-catenin signaling and NF-κB signaling contributes to apical periodontitis. Int Immunopharmacol. 2021;98:107843.
pubmed: 34153668
doi: 10.1016/j.intimp.2021.107843
Kumar A, Mahendra J, Mahendra L, Abdulkarim HH, Sayed M, Mugri MH, et al. Synergistic effect of biphasic calcium phosphate and platelet-rich fibrin attenuate markers for inflammation and osteoclast differentiation by suppressing NF-κB/MAPK signaling pathway in chronic periodontitis. Molecules. 2021;26(21):6578.
Li L, Luo W, Qian Y, Zhu W, Qian J, Li J, et al. Luteolin protects against diabetic cardiomyopathy by inhibiting NF-κB-mediated inflammation and activating the Nrf2-mediated antioxidant responses. Phytomedicine. 2019;59:152774.
doi: 10.1016/j.phymed.2018.11.034
Yang Y, Tan X, Xu J, Wang T, Liang T, Xu X, et al. Luteolin alleviates neuroinflammation via downregulating the TLR4/TRAF6/NF-κB pathway after intracerebral hemorrhage. Biomed Pharmacother. 2020;126:110044.
Che DN, Shin JY, Kang HJ, Cho BO, Kim YS, Jang SI. Luteolin suppresses IL-31 production in IL-33-stimulated mast cells through MAPK and NF-κB signaling pathways. Int Immunopharmacol. 2020;83:106403.
pubmed: 32197229
doi: 10.1016/j.intimp.2020.106403
Nash LA, Sullivan PJ, Peters SJ, Ward WE. Rooibos flavonoids, orientin and luteolin, stimulate mineralization in human osteoblasts through the wnt pathway. Mol Nutr Food Res. 2015;59(3):443–53.
pubmed: 25488131
doi: 10.1002/mnfr.201400592
Yang H, Liu Q, Ahn JH, Kim SB, Kim YC, Sung SH, et al. Luteolin downregulates IL-1β-induced MMP-9 and– 13 expressions in osteoblasts via inhibition of ERK signalling pathway. J Enzyme Inhib Med Chem. 2012;27(2):261–6.
pubmed: 21679050
doi: 10.3109/14756366.2011.587415
Zhang C, Zhang Y, Hu X, Zhao Z, Chen Z, Wang X, et al. Luteolin inhibits subretinal fibrosis and epithelial-mesenchymal transition in laser-induced mouse model via suppression of Smad2/3 and YAP signaling. Phytomedicine. 2023;116:154865.
pubmed: 37201365
doi: 10.1016/j.phymed.2023.154865