Exudative Age-Related Macular Degeneration: Association between Treatment Efficacy and Single-Nucleotide Variants in
Humans
Polymorphism, Single Nucleotide
Vascular Endothelial Growth Factor A
/ genetics
Male
Female
Aged
Interleukin-10
/ genetics
Intracellular Signaling Peptides and Proteins
/ genetics
Protein Serine-Threonine Kinases
/ genetics
Interleukin-9
/ genetics
Collagen Type X
/ genetics
Treatment Outcome
Macular Degeneration
/ genetics
Aged, 80 and over
DNA-Binding Proteins
/ genetics
Middle Aged
Genotype
Collagen Type VIII
ELISA
age-related macular degeneration
anti-VEGFA therapy
single-nucleotide variants
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
22 Jun 2024
22 Jun 2024
Historique:
received:
20
05
2024
revised:
12
06
2024
accepted:
20
06
2024
medline:
13
7
2024
pubmed:
13
7
2024
entrez:
13
7
2024
Statut:
epublish
Résumé
Age-related macular degeneration (AMD) is a progressive neurodegenerative condition leading to vision loss and eventual blindness, with exudative AMD posing a heightened risk due to choroidal neovascularization and localized edema. Therapies targeting the VEGF pathway aim to address this mechanism for treatment effectiveness. Our study aimed to evaluate associations between specific genetic variants (
Identifiants
pubmed: 38999967
pii: ijms25136859
doi: 10.3390/ijms25136859
pii:
doi:
Substances chimiques
Vascular Endothelial Growth Factor A
0
Interleukin-10
130068-27-8
VEGFA protein, human
0
Intracellular Signaling Peptides and Proteins
0
Protein Serine-Threonine Kinases
EC 2.7.11.1
Interleukin-9
0
TRIB1 protein, human
0
Collagen Type X
0
COL10A1 protein, human
0
Col8A1 protein, human
0
IL10 protein, human
0
DNA-Binding Proteins
0
IL9 protein, human
0
Collagen Type VIII
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : The Research Council of Lithuania under the initiative of Researcher Group Projects.
ID : S-MIP-23-96