LPA-Induced Thromboxane A2-Mediated Vasoconstriction Is Limited to Poly-Unsaturated Molecular Species in Mouse Aortas.
lysophosphatidic acid
lysophosphatidic acid receptor 1
thromboxane
vasoconstriction
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
22 Jun 2024
22 Jun 2024
Historique:
received:
06
04
2024
revised:
18
06
2024
accepted:
20
06
2024
medline:
13
7
2024
pubmed:
13
7
2024
entrez:
13
7
2024
Statut:
epublish
Résumé
We have previously reported that, in aortic rings, 18:1 lysophosphatidic acid (LPA) can induce both vasodilation and vasoconstriction depending on the integrity of the endothelium. The predominant molecular species generated in blood serum are poly-unsaturated LPA species, yet the vascular effects of these species are largely unexplored. We aimed to compare the vasoactive effects of seven naturally occurring LPA species in order to elucidate their potential pathophysiological role in vasculopathies. Vascular tone was measured using myography, and thromboxane A
Identifiants
pubmed: 38999980
pii: ijms25136872
doi: 10.3390/ijms25136872
pii:
doi:
Substances chimiques
Thromboxane A2
57576-52-0
Lysophospholipids
0
lysophosphatidic acid
PG6M3969SG
Calcium
SY7Q814VUP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Hungarian National Research, Development, and Innovation Office
ID : K-125174, PD-132851, K-135683, K-139230, NVKP_16-1-2016-0042, EFOP-3.6.3-VEKOP-16-2017-00009
Organisme : Ministry for Innovation and Technology from the Hungarian NRDI Fund
ID : 2020-1.1.6-JÖVŐ-2021-00010; 2020-1.1.6-JÖVŐ-2021-00013; TKP2021-EGA-25