Impact of RAAS Receptors and Membrane-Bound Transporter System in the Left Ventricle during the Long-Term Control of Hypertension.
Animals
Renin-Angiotensin System
Hypertension
/ metabolism
Heart Ventricles
/ metabolism
Myocytes, Cardiac
/ metabolism
Receptor, Angiotensin, Type 1
/ metabolism
Rats
Proto-Oncogene Mas
Blood Pressure
Male
Mice
Receptor, Angiotensin, Type 2
/ metabolism
Sarcolemma
/ metabolism
Sodium-Potassium-Exchanging ATPase
/ metabolism
Sodium-Calcium Exchanger
/ metabolism
Mice, Transgenic
(mREN2)27
Angiotensin 1–7
MAS1 proto-oncogene protein
Renin–Angiotensin–Aldosterone System
angiotensin II
angiotensin II receptor subtype
angiotensin-converting enzyme
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
26 Jun 2024
26 Jun 2024
Historique:
received:
13
05
2024
revised:
21
06
2024
accepted:
24
06
2024
medline:
13
7
2024
pubmed:
13
7
2024
entrez:
13
7
2024
Statut:
epublish
Résumé
The Renin-Angiotensin-Aldosterone System (RAAS) has been implicated in systemic and neurogenic hypertension. The infusion of RAAS inhibitors blunted arterial pressure and efficacy of use-dependent synaptic transmission in sympathetic ganglia. The current investigation aims to elucidate the impact of RAAS-mediated receptors on left ventricular cardiomyocytes and the role of the sarcolemma-bound carrier system in the heart of the hypertensive transgene model. A significant increase in mRNA and the protein expression for angiotensin II (AngII) receptor subtype-1 (AT
Identifiants
pubmed: 39000106
pii: ijms25136997
doi: 10.3390/ijms25136997
pii:
doi:
Substances chimiques
Receptor, Angiotensin, Type 1
0
Proto-Oncogene Mas
0
Receptor, Angiotensin, Type 2
0
Sodium-Potassium-Exchanging ATPase
EC 7.2.2.13
Sodium-Calcium Exchanger
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.