Elucidation of the Gemcitabine Transporters of

Gemcitabine Deoxycytidine / analogs & derivatives Humans Drug Resistance, Neoplasm / genetics Membrane Transport Proteins / metabolism Escherichia coli K12 / genetics Gammaproteobacteria / genetics Escherichia coli Proteins / genetics Drug Resistance, Bacterial / genetics Antimetabolites, Antineoplastic / pharmacology
Escherichia coli K-12 chemoresistance gamma-proteobacteria gemcitabine nucleoside transporters

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
27 Jun 2024
Historique:
received: 03 06 2024
revised: 22 06 2024
accepted: 24 06 2024
medline: 13 7 2024
pubmed: 13 7 2024
entrez: 13 7 2024
Statut: epublish

Résumé

Gemcitabine (2',2'-difluoro-2'-deoxycytidine), a widely used anticancer drug, is considered a gold standard in treating aggressive pancreatic cancers. Gamma-proteobacteria that colonize the pancreatic tumors contribute to chemoresistance against gemcitabine by metabolizing the drug to a less active and deaminated form. The gemcitabine transporters of these bacteria are unknown to date. Furthermore, there is no complete knowledge of the gemcitabine transporters in

Identifiants

DOI: 10.3390/ijms25137012 PMID: 39000123
pubmed: 39000123
pii: ijms25137012
doi: 10.3390/ijms25137012
pii:
doi:

Substances chimiques

Gemcitabine 0
Deoxycytidine 0W860991D6
Membrane Transport Proteins 0
Escherichia coli Proteins 0
Antimetabolites, Antineoplastic 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Greece and EU-European Regional Development Fund
ID : MIS 5047236
Organisme : Greece and EU-European Social Fund
ID : MIS 5033021

Auteurs

Nikoleta Iosifidou (N)

Laboratory of Biological Chemistry, Department of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.

Eleni Anagnostopoulou (E)

Laboratory of Biological Chemistry, Department of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.

Maria Botou (M)

Laboratory of Biological Chemistry, Department of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.

Eirini Kalfa (E)

Laboratory of Biological Chemistry, Department of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.

Ekaterini Tatsaki (E)

Laboratory of Biological Chemistry, Department of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.
ORCID: 0000-0002-3696-5141

Stathis Frillingos (S)

Laboratory of Biological Chemistry, Department of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.
University Research Center of Ioannina (URCI), Institute of Biosciences, 45110 Ioannina, Greece.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Gemcitabine › Elucidation of the Gemcitabine Transporters of
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Nucléosides pyrimidiques › Désoxycytidine › Elucidation of the Gemcitabine Transporters of
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Elucidation of the Gemcitabine Transporters of
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance aux médicaments antinéoplasiques › Elucidation of the Gemcitabine Transporters of
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Elucidation of the Gemcitabine Transporters of
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Escherichia coli K12 › Elucidation of the Gemcitabine Transporters of
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Elucidation of the Gemcitabine Transporters of
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Protéines Escherichia coli › Elucidation of the Gemcitabine Transporters of
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance bactérienne aux médicaments › Elucidation of the Gemcitabine Transporters of
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Noxas › Antimétabolites › Antimétabolites antinéoplasiques › Elucidation of the Gemcitabine Transporters of