Small Cell Lung Carcinoma Cells Depend on KIF11 for Survival.

Humans Kinesins / metabolism Small Cell Lung Carcinoma / genetics Cell Line, Tumor Lung Neoplasms / genetics Cell Survival / drug effects Cell Proliferation bcl-X Protein / metabolism Gene Expression Regulation, Neoplastic Apoptosis / genetics Benzamides Quinazolines
BCL2-like 1 (BCL2L1) apoptosis kinesin family member 11 (KIF11) small cell lung cancer (SCLC)

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
30 Jun 2024
Historique:
received: 01 05 2024
revised: 28 06 2024
accepted: 28 06 2024
medline: 13 7 2024
pubmed: 13 7 2024
entrez: 13 7 2024
Statut: epublish

Résumé

Few efficacious treatment options are available for patients with small cell lung carcinoma (SCLC), indicating the need to develop novel therapeutic approaches. In this study, we explored kinesin family member 11 (KIF11), a potential therapeutic target in SCLC. An analysis of publicly available data suggested that

Identifiants

DOI: 10.3390/ijms25137230 PMID: 39000337
pubmed: 39000337
pii: ijms25137230
doi: 10.3390/ijms25137230
pii:
doi:

Substances chimiques

Kinesins EC 3.6.4.4
KIF11 protein, human 0
bcl-X Protein 0
BCL2L1 protein, human 0
ispinesib BKT5F9C2NI
Benzamides 0
Quinazolines 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Japan Society for the Promotion of Science
ID : 21K08161 to MY; 22K06962 to YS

Auteurs

Yuji Sakuma (Y)

Department of Molecular Medicine, Research Institute for Immunology, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan.
ORCID: 0000-0003-2298-1359

Sachie Hirai (S)

Department of Molecular Medicine, Research Institute for Immunology, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan.

Miki Yamaguchi (M)

Department of Molecular Medicine, Research Institute for Immunology, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan.

Masashi Idogawa (M)

Department of Medical Genome Sciences, Cancer Research Institute, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan.
ORCID: 0000-0002-8507-1726

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Small Cell Lung Carcinoma Cells Depend on...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines associées aux microtubules › Kinésine › Small Cell Lung Carcinoma Cells Depend on...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Tumeurs des bronches › Carcinome bronchogénique › Carcinome pulmonaire à petites cellules › Small Cell Lung Carcinoma Cells Depend on...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Small Cell Lung Carcinoma Cells Depend on...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Small Cell Lung Carcinoma Cells Depend on...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Small Cell Lung Carcinoma Cells Depend on...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Small Cell Lung Carcinoma Cells Depend on...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Protéine bcl-X › Small Cell Lung Carcinoma Cells Depend on...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Small Cell Lung Carcinoma Cells Depend on...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Small Cell Lung Carcinoma Cells Depend on...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Benzoates › Benzamides › Small Cell Lung Carcinoma Cells Depend on...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinazolines › Small Cell Lung Carcinoma Cells Depend on...