Loss of Mitochondrial Tusc2/Fus1 Triggers a Brain Pro-Inflammatory Microenvironment and Early Spatial Memory Impairment.

Animals Mice Female Mitochondria / metabolism Spatial Memory Male Memory Disorders / metabolism Brain / metabolism Mice, Knockout Mice, Inbred C57BL Inflammation / metabolism Membrane Proteins / metabolism Astrocytes / metabolism Cellular Microenvironment Mitochondrial Proteins / metabolism Hippocampus / metabolism
Fus1 Tusc2 aging brain immune populations calcium cognitive impairment mitochondria neuroinflammation sex-dependent changes

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
05 Jul 2024
Historique:
received: 02 05 2024
revised: 01 07 2024
accepted: 03 07 2024
medline: 13 7 2024
pubmed: 13 7 2024
entrez: 13 7 2024
Statut: epublish

Résumé

Brain pathological changes impair cognition early in disease etiology. There is an urgent need to understand aging-linked mechanisms of early memory loss to develop therapeutic strategies and prevent the development of cognitive impairment. Tusc2 is a mitochondrial-resident protein regulating Ca

Identifiants

DOI: 10.3390/ijms25137406 PMID: 39000512
pubmed: 39000512
pii: ijms25137406
doi: 10.3390/ijms25137406
pii:
doi:

Substances chimiques

Membrane Proteins 0
Mitochondrial Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Tonie Farris (T)

Department of Biomedical Sciences, School of Graduate Studies, Meharry Medical College, Nashville, TN 37208, USA.
Department of Biochemistry, Cancer Biology, Neuroscience & Pharmacology, School of Medicine, Meharry Medical College, Nashville, TN 37208, USA.

Salvador González-Ochoa (S)

Department of Biochemistry, Cancer Biology, Neuroscience & Pharmacology, School of Medicine, Meharry Medical College, Nashville, TN 37208, USA.
ORCID: 0000-0002-5787-4759

Muna Mohammed (M)

Department of Biomedical Sciences, School of Graduate Studies, Meharry Medical College, Nashville, TN 37208, USA.
Department of Biochemistry, Cancer Biology, Neuroscience & Pharmacology, School of Medicine, Meharry Medical College, Nashville, TN 37208, USA.

Harshana Rajakaruna (H)

The Office for Research and Innovation, Meharry Medical College, Nashville, TN 37208, USA.

Jane Tonello (J)

Department of Biochemistry, Cancer Biology, Neuroscience & Pharmacology, School of Medicine, Meharry Medical College, Nashville, TN 37208, USA.

Thanigaivelan Kanagasabai (T)

Department of Biomedical Sciences, School of Graduate Studies, Meharry Medical College, Nashville, TN 37208, USA.
Department of Biochemistry, Cancer Biology, Neuroscience & Pharmacology, School of Medicine, Meharry Medical College, Nashville, TN 37208, USA.
ORCID: 0000-0002-9867-8076

Olga Korolkova (O)

Department of Biochemistry, Cancer Biology, Neuroscience & Pharmacology, School of Medicine, Meharry Medical College, Nashville, TN 37208, USA.

Akiko Shimamoto (A)

Department of Biochemistry, Cancer Biology, Neuroscience & Pharmacology, School of Medicine, Meharry Medical College, Nashville, TN 37208, USA.

Alla Ivanova (A)

Department of Biomedical Sciences, School of Graduate Studies, Meharry Medical College, Nashville, TN 37208, USA.
Department of Biochemistry, Cancer Biology, Neuroscience & Pharmacology, School of Medicine, Meharry Medical College, Nashville, TN 37208, USA.
ORCID: 0000-0002-4149-5105

Anil Shanker (A)

Department of Biochemistry, Cancer Biology, Neuroscience & Pharmacology, School of Medicine, Meharry Medical College, Nashville, TN 37208, USA.
The Office for Research and Innovation, Meharry Medical College, Nashville, TN 37208, USA.
ORCID: 0000-0001-6372-3669

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Loss of Mitochondrial Tusc2/Fus1 Triggers a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Loss of Mitochondrial Tusc2/Fus1 Triggers a...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Loss of Mitochondrial Tusc2/Fus1 Triggers a...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Mémoire › Mémoire spatiale › Loss of Mitochondrial Tusc2/Fus1 Triggers a...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Manifestations neurocomportementales › Troubles de la mémoire › Loss of Mitochondrial Tusc2/Fus1 Triggers a...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Loss of Mitochondrial Tusc2/Fus1 Triggers a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Loss of Mitochondrial Tusc2/Fus1 Triggers a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Loss of Mitochondrial Tusc2/Fus1 Triggers a...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Loss of Mitochondrial Tusc2/Fus1 Triggers a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Loss of Mitochondrial Tusc2/Fus1 Triggers a...
questionsmedicales.fr › Cellules › Névroglie › Astrocytes › Loss of Mitochondrial Tusc2/Fus1 Triggers a...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Loss of Mitochondrial Tusc2/Fus1 Triggers a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Loss of Mitochondrial Tusc2/Fus1 Triggers a...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Loss of Mitochondrial Tusc2/Fus1 Triggers a...