Exploring Fibrosis Pathophysiology in Lean and Obese Metabolic-Associated Fatty Liver Disease: An In-Depth Comparison.

Humans Non-alcoholic Fatty Liver Disease / metabolism Obesity / metabolism Liver Cirrhosis / metabolism Animals Hepatic Stellate Cells / metabolism Disease Models, Animal
CCl4 MCD diet animal models fibrosis lean NAFLD

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
05 Jul 2024
Historique:
received: 30 05 2024
revised: 21 06 2024
accepted: 28 06 2024
medline: 13 7 2024
pubmed: 13 7 2024
entrez: 13 7 2024
Statut: epublish

Résumé

While obesity-related nonalcoholic fatty liver disease (NAFLD) is linked with metabolic dysfunctions such as insulin resistance and adipose tissue inflammation, lean NAFLD more often progresses to liver fibrosis even in the absence of metabolic syndrome. This review aims to summarize the current knowledge regarding the mechanisms of liver fibrosis in lean NAFLD. The most commonly used lean NAFLD models include a methionine/choline-deficient (MCD) diet, a high-fat diet with carbon tetrachloride (CCl

Identifiants

DOI: 10.3390/ijms25137405 PMID: 39000518
pubmed: 39000518
pii: ijms25137405
doi: 10.3390/ijms25137405
pii:
doi:

Types de publication

Journal Article Review Comparative Study

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Republic of Serbia Ministry of Science, Innovation and Technological Development
ID : 451-03-66/2024-03/200110

Auteurs

Milena Vesković (M)

Institute of Pathophysiology, Faculty of Medicine, University of Belgrade, Dr Subotića 9, 11000 Belgrade, Serbia.
ORCID: 0000-0002-7505-5466

Milka Pejović (M)

Primary Health Center "Vračar", Velimira Bate Živojinovića 16, 11000 Belgrade, Serbia.

Nikola Šutulović (N)

Institute of Medical Physiology, Faculty of Medicine, University of Belgrade, Višegradska 26, 11000 Belgrade, Serbia.
ORCID: 0000-0002-9499-3247

Dragan Hrnčić (D)

Institute of Medical Physiology, Faculty of Medicine, University of Belgrade, Višegradska 26, 11000 Belgrade, Serbia.
ORCID: 0000-0003-0806-444X

Aleksandra Rašić-Marković (A)

Institute of Medical Physiology, Faculty of Medicine, University of Belgrade, Višegradska 26, 11000 Belgrade, Serbia.

Olivera Stanojlović (O)

Institute of Medical Physiology, Faculty of Medicine, University of Belgrade, Višegradska 26, 11000 Belgrade, Serbia.

Dušan Mladenović (D)

Institute of Pathophysiology, Faculty of Medicine, University of Belgrade, Dr Subotića 9, 11000 Belgrade, Serbia.
ORCID: 0000-0002-8921-6232

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Exploring Fibrosis Pathophysiology in Lean and...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Stéatose hépatique › Stéatose hépatique non alcoolique › Exploring Fibrosis Pathophysiology in Lean and...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Exploring Fibrosis Pathophysiology in Lean and...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fibrose › Cirrhose du foie › Exploring Fibrosis Pathophysiology in Lean and...
questionsmedicales.fr › Eucaryotes › Animaux › Exploring Fibrosis Pathophysiology in Lean and...
questionsmedicales.fr › Cellules › Cellules étoilées du foie › Exploring Fibrosis Pathophysiology in Lean and...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Exploring Fibrosis Pathophysiology in Lean and...