Reducing racial and ethnic disparities in cardiovascular outcomes among cancer survivors.
Cancer survivors
Cardio-oncology
Cardiovascular outcomes
Racial disparities
Journal
Current oncology reports
ISSN: 1534-6269
Titre abrégé: Curr Oncol Rep
Pays: United States
ID NLM: 100888967
Informations de publication
Date de publication:
13 Jul 2024
13 Jul 2024
Historique:
accepted:
02
07
2024
medline:
14
7
2024
pubmed:
14
7
2024
entrez:
13
7
2024
Statut:
aheadofprint
Résumé
Analyze current evidence on racial/ethnic disparities in cardiovascular outcomes among cancer survivors, identifying factors and proposing measures to address health inequities. Existing literature indicates that the Black population experiences worse cardiovascular outcomes following the diagnosis of both initial primary cancer and second primary cancer, with a notably higher prevalence of cardio-toxic events, particularly among breast cancer survivors. Contributing socioeconomic factors to these disparities include unfavorable social determinants of health, inadequate insurance coverage, and structural racism within the healthcare system. Additionally, proinflammatory epigenetic modification is hypothesized to be a contributing genetic variation factor. Addressing these disparities requires a multiperspective approach, encompassing efforts to address racial disparities and social determinants of health within the healthcare system, refine healthcare policies and access, and integrate historically stigmatized racial groups into clinical research. Racial and ethnic disparities persist in cardiovascular outcomes among cancer survivors, driven by multifactorial causes, predominantly associated with social determinants of health. Addressing these healthcare inequities is imperative, and timely efforts must be implemented to narrow the existing gap effectively.
Identifiants
pubmed: 39002054
doi: 10.1007/s11912-024-01578-7
pii: 10.1007/s11912-024-01578-7
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Références
Ahmad FB, Anderson RN. The Leading Causes of Death in the US for 2020. JAMA. 2021;325(18):1829–30.
pubmed: 33787821
pmcid: 8145781
doi: 10.1001/jama.2021.5469
Dattani, SSF, Ritchie H. Causes of death. 2023; Available from: https://ourworldindata.org/causes-of-death#research-writing . Cited 2023 November 19, 2023
Birger M, et al. Spending on Cardiovascular Disease and Cardiovascular Risk Factors in the United States: 1996 to 2016. Circulation. 2021;144(4):271–82.
pubmed: 33926203
pmcid: 8316421
doi: 10.1161/CIRCULATIONAHA.120.053216
Prager GW, et al. Global cancer control: responding to the growing burden, rising costs and inequalities in access. ESMO Open. 2018;3(2):e000285.
pubmed: 29464109
pmcid: 5812392
doi: 10.1136/esmoopen-2017-000285
Lopez-Neyman SM, et al. Racial disparities and prevalence of cardiovascular disease risk factors, cardiometabolic risk factors, and cardiovascular health metrics among US adults: NHANES 2011–2018. Sci Rep. 2022;12(1):19475.
pubmed: 36376533
pmcid: 9663590
doi: 10.1038/s41598-022-21878-x
Zavala VA, et al. Cancer health disparities in racial/ethnic minorities in the United States. Br J Cancer. 2021;124(2):315–32.
pubmed: 32901135
doi: 10.1038/s41416-020-01038-6
Sturgeon KM, et al. A population-based study of cardiovascular disease mortality risk in US cancer patients. Eur Heart J. 2019;40(48):3889–97.
pubmed: 31761945
pmcid: 6925383
doi: 10.1093/eurheartj/ehz766
Strongman H, et al. Does Cardiovascular Mortality Overtake Cancer Mortality During Cancer Survivorship?: An English Retrospective Cohort Study. JACC CardioOncol. 2022;4(1):113–23.
pubmed: 35492818
pmcid: 9040113
doi: 10.1016/j.jaccao.2022.01.102
Raisi-Estabragh Z, et al. Temporal trends in disease-specific causes of cardiovascular mortality amongst patients with cancer in the USA between 1999 and 2019. Eur Heart J Qual Care Clin Outcomes. 2022;9(1):54–63.
pubmed: 35435219
pmcid: 9745666
doi: 10.1093/ehjqcco/qcac016
Yeh TL, et al. Risk of cardiovascular diseases in cancer patients: A nationwide representative cohort study in Taiwan. BMC Cancer. 2022;22(1):1198.
pubmed: 36411401
pmcid: 9677651
doi: 10.1186/s12885-022-10314-y
Kobo O, et al. Trends in cardiovascular mortality of cancer patients in the US over two decades 1999–2019. Int J Clin Pract. 2021;75(11):e14841.
pubmed: 34514707
doi: 10.1111/ijcp.14841
Zhu C, et al. Racial and Ethnic Disparities in All-Cause and Cardiovascular Mortality Among Cancer Patients in the U.S. JACC Cardio Oncol. 2023;5(1):55–66.
doi: 10.1016/j.jaccao.2022.10.013
Ganatra S, et al. Impact of Social Vulnerability on Comorbid Cancer and Cardiovascular Disease Mortality in the United States. JACC CardioOncol. 2022;4(3):326–37.
pubmed: 36213357
pmcid: 9537091
doi: 10.1016/j.jaccao.2022.06.005
Sung H, et al. Mediators of Black-White inequities in cardiovascular mortality among survivors of 18 cancers in the USA. Int J Epidemiol, 2023.
Koene RJ, et al. Shared Risk Factors in Cardiovascular Disease and Cancer. Circulation. 2016;133(11):1104–14.
pubmed: 26976915
pmcid: 4800750
doi: 10.1161/CIRCULATIONAHA.115.020406
Carnethon MR, et al. Cardiovascular Health in African Americans: A Scientific Statement From the American Heart Association. Circulation. 2017;136(21):e393–423.
pubmed: 29061565
doi: 10.1161/CIR.0000000000000534
Noyd DH, et al. Cardiovascular Risk Factor Disparities in Adult Survivors of Childhood Cancer Compared With the General Population. JACC CardioOncol. 2023;5(4):489–500.
pubmed: 37614575
pmcid: 10443116
doi: 10.1016/j.jaccao.2023.01.011
Fazal M, et al. Racial and Ethnic Disparities in Cardio-Oncology: A Call to Action. JACC CardioOncol. 2021;3(2):201–4.
pubmed: 34308372
pmcid: 8301207
doi: 10.1016/j.jaccao.2021.05.001
Hu Q., et al., Disparities in Cardiovascular Disease Risk Among Hispanic Breast Cancer Survivors in a Population-Based Cohort. JNCI Cancer Spectr, 2021. 5(2).
Daviglus ML, et al. Prevalence of major cardiovascular risk factors and cardiovascular diseases among Hispanic/Latino individuals of diverse backgrounds in the United States. JAMA. 2012;308(17):1775–84.
pubmed: 23117778
pmcid: 3777250
doi: 10.1001/jama.2012.14517
Rodriguez CJ, et al. Status of cardiovascular disease and stroke in Hispanics/Latinos in the United States: a science advisory from the American Heart Association. Circulation. 2014;130(7):593–625.
pubmed: 25098323
pmcid: 4577282
doi: 10.1161/CIR.0000000000000071
Abraido-Lanza AF, Echeverria SE, Florez KR. Latino Immigrants, Acculturation, and Health: Promising New Directions in Research. Annu Rev Public Health. 2016;37:219–36.
pubmed: 26735431
pmcid: 5337110
doi: 10.1146/annurev-publhealth-032315-021545
Davila YR, Reifsnider E, Pecina I. Familismo: influence on Hispanic health behaviors. Appl Nurs Res. 2011;24(4):e67-72.
pubmed: 20974085
doi: 10.1016/j.apnr.2009.12.003
Asian American and Pacific Islander Heritage Month: May 2022. 2022 Jan 13, 2024]; Press Release Number CB22-FF.05:[Available from: https://www.census.gov/newsroom/facts-for-features/2022/asian-american-pacific-islander.html#:~:text=Asian%20American%20and%20Pacific%20Islander%20Heritage%20Month%3A%20May%202022 .
Solanki PA, et al. Risk of cancer-specific, cardiovascular, and all-cause mortality among Asian and Pacific Islander breast cancer survivors in the United States, 1991–2011. Springerplus. 2016;5:82.
pubmed: 26844029
pmcid: 4728166
doi: 10.1186/s40064-016-1726-3
Taparra K, Qu V, Pollom E. Disparities in Survival and Comorbidity Burden Between Asian and Native Hawaiian and Other Pacific Islander Patients With Cancer. JAMA Netw Open. 2022;5(8):e2226327.
pubmed: 35960520
pmcid: 9375163
doi: 10.1001/jamanetworkopen.2022.26327
Moy KL, Sallis JF, David KJ. Health indicators of Native Hawaiian and Pacific Islanders in the United States. J Community Health. 2010;35(1):81–92.
pubmed: 19856087
doi: 10.1007/s10900-009-9194-0
Gomez SL, et al. Immigration and acculturation in relation to health and health-related risk factors among specific Asian subgroups in a health maintenance organization. Am J Public Health. 2004;94(11):1977–84.
pubmed: 15514240
pmcid: 1448572
doi: 10.2105/AJPH.94.11.1977
Minocher Homji, R.S., S. Lakhoo, and J.G. Ray, Recruitment of immigrant and ethnic minorities in primary prevention trials of cardiovascular disease. QJM, 2011. 104(6): p. 469–76.
Satti, D.I., et al., Associations Between Social Determinants of Health and Cardiovascular Health of US Adult Cancer Survivors. JACC: CardioOncology. 0(0).
Shrider E. A., C.J. Poverty in the United States: 2022. Current Population Reports. 2023; Available from: https://www.census.gov/content/dam/Census/library/publications/2023/demo/p60-280.pdf . Accessed 14 November 2023.
Shi T, et al. Insurance disparity in cardiovascular mortality among non-elderly cancer survivors. Cardiooncology. 2021;7(1):11.
pubmed: 33743837
pmcid: 7980587
Branch B., C.D. Health Insurance Coverage by Race and Hispanic Origin:2021. U. S. Department of Commerce, 2022; Available from: https://www.census.gov/content/dam/Census/library/publications/2022/acs/acsbr-012.pdf . Accessed 9 November 2023
Cha A. E., C.R.A. Demographic Variation in Health Insurance Coverage: United States, 2021. National Health Statistics Reports. 2022 9 November 2023. ]; Available from: https://www.cdc.gov/nchs//data/nhsr/nhsr177.pdf .
Stabellini N, et al. Racial disparities in breast cancer treatment patterns and treatment related adverse events. Sci Rep. 2023;13(1):1233.
pubmed: 36683066
pmcid: 9868122
doi: 10.1038/s41598-023-27578-4
Vince RA Jr, et al. Reporting of Racial Health Disparities Research: Are We Making Progress? J Clin Oncol. 2022;40(1):8–11.
pubmed: 34694897
doi: 10.1200/JCO.21.01780
Stanley J, et al. The impact of racism on the future health of adults: protocol for a prospective cohort study. BMC Public Health. 2019;19(1):346.
pubmed: 30922286
pmcid: 6437906
doi: 10.1186/s12889-019-6664-x
Paradies Y, et al. Racism as a Determinant of Health: A Systematic Review and Meta-Analysis. PLoS ONE. 2015;10(9):e0138511.
pubmed: 26398658
pmcid: 4580597
doi: 10.1371/journal.pone.0138511
Litvak A, et al. Racial disparities in the rate of cardiotoxicity of HER2-targeted therapies among women with early breast cancer. Cancer. 2018;124(9):1904–11.
pubmed: 29381193
doi: 10.1002/cncr.31260
DeRemer DL, et al. Racial and ethnic differences in cardiac surveillance evaluation of patients treated with anthracycline-based chemotherapy. J Am Heart Assoc. 2023;12(10):e027981.
pubmed: 37158063
pmcid: 10227284
doi: 10.1161/JAHA.122.027981
Stabellini, N., et al., Allostatic load and cardiovascular outcomes in males with prostate cancer. JNCI Cancer Spectr, 2023. 7(2).
Stabellini N, et al. Allostatic Load/Chronic Toxic Stress and Cardiovascular Outcomes in Breast, Lung and Colon Cancer Patients. Circulation. 2023;148(Suppl_1):A1454.
doi: 10.1161/circ.148.suppl_1.14540
Stabellini N, et al. Social Determinants of Health and Racial Disparities in Cardiac Events in Breast Cancer. J Natl Compr Canc Netw. 2023;21(7):705-714e17.
pubmed: 37433439
doi: 10.6004/jnccn.2023.7023
Stabellini N, et al. Racial Differences in Chronic Stress/Allostatic Load Variation Due to Androgen Deprivation Therapy in Prostate Cancer. JACC CardioOncol. 2022;4(4):555–7.
pubmed: 36909936
pmcid: 9998463
doi: 10.1016/j.jaccao.2022.10.004
Powell-Wiley TM, et al. Social Determinants of Cardiovascular Disease. Circ Res. 2022;130(5):782–99.
pubmed: 35239404
pmcid: 8893132
doi: 10.1161/CIRCRESAHA.121.319811
Stabellini, N., et al., Social Determinants of Health Data Improve the Prediction of Cardiac Outcomes in Females with Breast Cancer. Cancers (Basel), 2023. 15(18).
Javed Z, et al. Race, Racism, and Cardiovascular Health: Applying a Social Determinants of Health Framework to Racial/Ethnic Disparities in Cardiovascular Disease. Circ Cardiovasc Qual Outcomes. 2022;15(1):e007917.
pubmed: 35041484
doi: 10.1161/CIRCOUTCOMES.121.007917
Yancy CW, Khan SS. Replacing Race With Social Determinants of Health in Risk Prediction-Getting It Right. JAMA Cardiol. 2022;7(8):856.
pubmed: 35793097
pmcid: 10286112
doi: 10.1001/jamacardio.2022.1909
Kraus MW, Rucker JM, Richeson JA. Americans misperceive racial economic equality. Proc Natl Acad Sci U S A. 2017;114(39):10324–31.
pubmed: 28923915
pmcid: 5625917
doi: 10.1073/pnas.1707719114
Niederdeppe J, et al. Communication About Health Disparities in the Mass Media. J Commun. 2013;63(1):8–30.
doi: 10.1111/jcom.12003
Williams DR, Rucker TD. Understanding and addressing racial disparities in health care. Health Care Financ Rev. 2000;21(4):75–90.
pubmed: 11481746
pmcid: 4194634
Nesbitt S, Palomarez RE. Review: Increasing Awareness and Education on Health Disparities for Health Care Providers. Ethn Dis. 2016;26(2):181–90.
pubmed: 27103768
pmcid: 4836898
doi: 10.18865/ed.26.2.181
Satti, D.I., et al., Associations Between Social Determinants of Health and Cardiovascular Health of US Adult Cancer Survivors. JACC: CardioOncology, 2023. 0(0).
Patel SR, et al. Inequity in care delivery in cardio-oncology: dissecting disparities in underrepresented populations. Front Oncol. 2023;13:1124447.
pubmed: 37361603
pmcid: 10289233
doi: 10.3389/fonc.2023.1124447
Gunderson JM, et al. Community Health Workers as an Extension of Care Coordination in Primary Care: A Community-Based Cosupervisory Model. J Ambul Care Manage. 2018;41(4):333–40.
pubmed: 30015685
pmcid: 6112848
doi: 10.1097/JAC.0000000000000255
Johnson, M., Cardio-Oncology and Health Equity. JACC: CardioOncology, 2023. 5.
Addison D, et al. Equity in Cardio-Oncology Care and Research: A Scientific Statement From the American Heart Association. Circulation. 2023;148(3):297–308.
pubmed: 37377045
doi: 10.1161/CIR.0000000000001158
Kuzawa CW, Sweet E. Epigenetics and the embodiment of race: developmental origins of US racial disparities in cardiovascular health. Am J Hum Biol. 2009;21(1):2–15.
pubmed: 18925573
doi: 10.1002/ajhb.20822
Holliday R. The inheritance of epigenetic defects. Science. 1987;238(4824):163–70.
pubmed: 3310230
doi: 10.1126/science.3310230
Berdasco M, Esteller M. Clinical epigenetics: seizing opportunities for translation. Nat Rev Genet. 2019;20(2):109–27.
pubmed: 30479381
doi: 10.1038/s41576-018-0074-2
Larsen F, et al. CpG islands as gene markers in the human genome. Genomics. 1992;13(4):1095–107.
pubmed: 1505946
doi: 10.1016/0888-7543(92)90024-M
Jones PA, Takai D. The role of DNA methylation in mammalian epigenetics. Science. 2001;293(5532):1068–70.
pubmed: 11498573
doi: 10.1126/science.1063852
Saban KL, et al. Epigenetics and social context: implications for disparity in cardiovascular disease. Aging Dis. 2014;5(5):346–55.
pubmed: 25276493
pmcid: 4173800
Libby P. Inflammation and cardiovascular disease mechanisms. Am J Clin Nutr. 2006;83(2):456S-460S.
pubmed: 16470012
doi: 10.1093/ajcn/83.2.456S
Kamp DW, Shacter E, Weitzman SA. Chronic inflammation and cancer: the role of the mitochondria. Oncology. 2011;25(5):400–10413.
pubmed: 21710835
Wielscher M, et al. DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases. Nat Commun. 2022;13(1):2408.
pubmed: 35504910
pmcid: 9065016
doi: 10.1038/s41467-022-29792-6
Ridker PM. Novel risk factors and markers for coronary disease. Adv Intern Med. 2000;45:391–418.
pubmed: 10635056
Sapkota Y, et al. Genetic Variants Associated with Therapy-Related Cardiomyopathy among Childhood Cancer Survivors of African Ancestry. Cancer Res. 2021;81(9):2556–65.
pubmed: 33288658
doi: 10.1158/0008-5472.CAN-20-2675
Churchwell K, et al. Call to Action: Structural Racism as a Fundamental Driver of Health Disparities: A Presidential Advisory From the American Heart Association. Circulation. 2020;142(24):e454–68.
pubmed: 33170755
doi: 10.1161/CIR.0000000000000936
Schwartz AL, et al. Why Diverse Clinical Trial Participation Matters. N Engl J Med. 2023;388(14):1252–4.
pubmed: 37017480
doi: 10.1056/NEJMp2215609
Hsu PC, et al. County poverty levels influence genome-wide DNA methylation profiles in African American and European American women. Transl Cancer Res. 2019;8(2):683–92.
pubmed: 35116801
pmcid: 8797389
doi: 10.21037/tcr.2019.02.07