Estimating cancer risk in carriers of Lynch syndrome variants in UK Biobank.
Genetic Predisposition to Disease
Germ-Line Mutation
Human Genetics
Neoplasms
Whole Exome Sequencing
Journal
Journal of medical genetics
ISSN: 1468-6244
Titre abrégé: J Med Genet
Pays: England
ID NLM: 2985087R
Informations de publication
Date de publication:
14 Jul 2024
14 Jul 2024
Historique:
received:
28
11
2023
accepted:
17
06
2024
medline:
15
7
2024
pubmed:
15
7
2024
entrez:
14
7
2024
Statut:
aheadofprint
Résumé
BackgroundLynch syndrome (LS) is an inherited cancer predisposition syndrome caused by genetic variants affecting DNA mismatch repair (MMR) genes 830 carriers of pathogenic or likely pathogenic ( Cumulative incidence of colorectal and endometrial cancer (EC) by age 70 years was elevated in These results support offering incidentally identified carriers of any
Identifiants
pubmed: 39004446
pii: jmg-2023-109791
doi: 10.1136/jmg-2023-109791
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.