Gut bacteria at 6 months of age are associated with immune cell status in 1-year-old children.
T cells
blood, gut microbiota
human
monocytes/macrophages
neutrophils
short‐chain fatty acids
Journal
Scandinavian journal of immunology
ISSN: 1365-3083
Titre abrégé: Scand J Immunol
Pays: England
ID NLM: 0323767
Informations de publication
Date de publication:
Apr 2024
Apr 2024
Historique:
revised:
27
11
2023
received:
11
05
2023
accepted:
28
11
2023
medline:
15
7
2024
pubmed:
15
7
2024
entrez:
15
7
2024
Statut:
ppublish
Résumé
Age-related gut bacterial changes during infancy have been widely studied, but it remains still unknown how these changes are associated with immune cell composition. This study's aim was to explore if the temporal development of gut bacteria during infancy prospectively affects immune cell composition. Faecal bacteria and short-chain fatty acids were analysed from 67 PreventADALL study participants at four timepoints (birth to 12 months) using reduced metagenome sequencing and gas chromatography. Immune cell frequencies were assessed using mass cytometry in whole blood samples at 12 months. The infants clustered into four groups based on immune cell composition: clusters 1 and 2 showed a high relative abundance of naïve cells, cluster 3 exhibited increased abundance of classical- and non-classical monocytes and clusters 3 and 4 had elevated neutrophil levels. At all age groups, we did observe significant associations between the gut microbiota and immune cell clusters; however, these were generally from low abundant species. Only at 6 months of age we observed significant associations between abundant (>8%) species and immune cell clusters. Bifidobacterium adolescentis and Porphyromonadaceae are associated with cluster 1, while Bacteroides fragilis and Bifidobacterium longum are associated with clusters 3 and 4 respectively. These species have been linked to T-cell polarization and maturation. No significant correlations were found between short-chain fatty acids and immune cell composition. Our findings suggest that abundant gut bacteria at 6 months may influence immune cell frequencies at 12 months, highlighting the potential role of gut microbiota in shaping later immune cell composition.
Substances chimiques
Fatty Acids, Volatile
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13346Subventions
Organisme : Arne Ingel's legat
Organisme : Barnestifteslen at Oslo University Hospital
Organisme : Forte
Organisme : Fürst Medical Laboratory, Oslo, Norway
Organisme : Health and Rehabilitation Norway
Organisme : Karolinska Institutet
Organisme : Norges Forskningsråd
Organisme : Norwegian Association of Asthma and Allergy
Organisme : Norwegian Society of Dermatology and Venerology
Organisme : Oslo University Hospital
Organisme : Region Stockholm (ALF-project and individual grants)
Organisme : Roche
Organisme : SFO-V Karolinska Institutet
Organisme : Swedish Asthma and Allergy Association's Research Foundation
Organisme : Swedish Order of Freemasons Foundation Barnhuset
Organisme : Swedish Research council
Organisme : Sykehuset Østfold
Organisme : The Cancer- and Allergy Foundation
Organisme : Delegation of the European Union to Norway, University of Oslo
Organisme : The Foundation for Healthcare and Allergy Research in Sweden - Vårdalstiftelsen
Organisme : The Fridtjof Nansen Institute
Organisme : The Hesselman foundation
Organisme : The Initiative for Clinical Therapy Research
Organisme : The King Gustaf V 80th Birthday Foundation
Organisme : The Kloster foundation
Organisme : The Konsul Th C Bergh's Foundation
Organisme : The Magnus Bergwall foundation
Organisme : The Pediatric Research Foundation at Astrid Lindgren Children's Hospital
Organisme : The Samaritan Foundation for Pediatric research
Organisme : The Sven Jerring Foundation
Organisme : The Swedish Heart-Lung Foundation
Organisme : The Swedish Society of Medicine
Organisme : Thermo-Fisher Uppsala, Sweden
Organisme : Universitetet i Oslo
Informations de copyright
© 2023 The Authors. Scandinavian Journal of Immunology published by John Wiley & Sons Ltd on behalf of The Scandinavian Foundation for Immunology.
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